Effects of Opuntia ficus indica (OFI) extracts on ethanol-induced psychomotor alterations were studied using Sprague-Dawley rats orally administered 4 g/kg of ethanol (EtOH group) or distilled water (control group). An OFI-group received OFI extracts (50, 100, and 200 mg/kg) 30 min prior to EtOH administration. Behavioral and hematological tests were evaluated 1, 2, 4, and 8 h after EtOH administration. Electroencephalogram (EEG) assessment was also performed. EtOH significantly (p<0.001) induced psychomotor alterations (reduced locomotion, balance, coordination, muscle strength, and tolerance to cold), compared with control group rats. Pre-treatment with OFI extracts alleviated alterations and also inhibited elevation of blood ethanol levels. EEG (percent of total power for delta, theta, alpha, and beta) results for OFI group rats were similar to control rats, indicating a countering of EtOHinduced EEG changes. Extracts of OFI can be effective for alleviation of psychomotor alterations induced by EtOH administration.
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World Health Organization. Global status report on alcohol and health. Available from: http://www.who.int/iris/handle/10665/44499. Accessed Jan. 18, 2014.
Abroms BD, Fillmore MT, Marczinski CA. Alcohol-induced impairment of behavioral control: Effects on the alteration and suppression of prepotent responses. J. Stud. Alcohol. 64: 687 (2003)
Haddad JJ. Alcoholism and neuro-immune-endocrine interactions: Physiochemical aspects. Biochem. Bioph. Res. Co. 323: 361–371 (2004)
World Health Organization. Traditional medicine. Available from: http://www.who.int/mediacentre/factsheets/2003/fs134/en/. Accessed Jan. 18, 2014.
Kaur M, Kaur A, Sharma R. Pharmacological actions of Opuntia ficus indica: A review. J. Appl. Pharm. Sci. 2: 15–18 (2012)
Cho JS, Lee YS. Neuroprotective and antioxidant effects of the butanol fraction prepared from Opuntia ficus-indica var. saboten. Biomol. Ther. 15: 205–211 (2007)
Wiese J, McPherson S, Odden MC, Shlipak MG. Effect of Opuntia ficus indica on symptoms of the alcohol hangover. Arch. Intern. Med. 164: 1334–1340 (2004)
Di D, Zhihua C, Ruifang F, Guangyu L, Tian L. Study on human brain after consuming alcohol based on EEG signal pp. 406–409. In: Computer Science and Information Technology (ICCSIT), 2010 3rd IEEE International Conference. July 9–11, Chengdu, China (2010)
Hui KM, Huen MS, Wang HY, Zheng H, Sigel E, Baur R, Ren H, Li ZW, Wong J, Xue H. Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi. Biochem. Pharmacol. 64: 1415–1424 (2002)
Maickel R, Nash J Jr. Drug interactions with ethanol: Effects on body temperature and motor impairment. Neuropharmacology 25: 315–322 (1986)
de la Peña IJI, Yoon SY, dela Peña JB, Park S, Yoon B, Kim HJ, Paek SH, Seo YK, Moon BS, Cheong JH. The ameliorating effect of Rosa roxburghii against ethanol-induced psychomotor alterations in rats. Am. J. Drug Alcohol Ab. 40: 75–81 (2013)
Manwani B, Liu F, Xu Y, Persky R, Li J, McCullough LD. Functional recovery in aging mice after experimental stroke. Brain Behav. Immun. 25: 1689–1700 (2011)
Greizerstein HB. Ethanol and indomethacin interactions in motor impairment, hypnosis, and body temperature. Psychopharmacology 84: 101–104 (1984)
Tsai M, PhD, Guochuan, Coyle M, Joseph T. The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu. Rev. Med. 49: 173–184 (1998)
Carta M, Mameli M, Valenzuela CF. Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability. J. Neurosci. 24: 3746–3751 (2004)
Lukas SE, Mendelson JH, Benedikt RA, Jones B. EEG alpha activity increases during transient episodes of ethanol-induced euphoria. Pharmacol. Biochem. Be. 25: 889–895 (1986)
Zhang YY, Li PF, Li D. Effect of Gingko biloba leaf extract on electroencephalography of rat with cerebral ischemia and perfusion. Acta Pharmacol. Sin. 24: 157–162 (2003)
Meyer JS, Quenzer LF. Alcohol. pp. 215–243. In: Psychopharmacology: Drugs, the Brain, and Behavior. Donini G, Emerson K, Sydney C, Via M. (eds). Sinauer Associates, Inc., Sunderland, MA, USA (2005)
Bustamante J, Karadayian AG, Lores-Arnaiz S, Cutrera RA. Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover. Alcohol 46: 473–479 (2012)
Zakhari S. Overview: How is alcohol metabolized by the body? Alcohol Res. Health. 29: 245–254 (2006)
Lee K-M, Kang H-S, Yun C-H, Kwak H-S. Potential in vitro protective effect of quercetin, catechin, caffeic acid and phytic acid against ethanol-induced oxidative stress in SK-Hep-1 cells. Biomol. Ther. 20: 492–498 (2012)
Tesoriere L, Butera D, Pintaudi AM, Allegra M, Livrea MA. Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: A comparative study with vitamin C. Am. J. Clin. Nutr. 80: 391–395 (2004)
Livrea MA, Tesoriere L. Health benefits and bioactive components of the fruits from Opuntia ficus-indica [L.] Mill. J. Prof. Assoc. Cactus Dev. 2006: 73–90 (2006)
Gentile C, Tesoriere L, Allegra M, Livrea MA, D’Alessio P. Antioxidant betalains from cactus pear (Opuntia-ficus indica) inhibit endothelial ICAM-1 expression. Ann. NY Acad. Sci. 1028: 481–486 (2004)
Alimi H, Hfaeidh N, Bouoni Z, Sakly M, Ben Rhouma K. Protective effect of Opuntia ficus indica f. inermis prickly pear juice upon ethanol-induced damages in rat erythrocytes. Alcohol 46: 235–243 (2012)
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dela Peña, I.J.I., Yoon, S.Y., Kim, H.J. et al. Alleviating effects of Opuntia ficus indica extracts on psychomotor alterations induced by ethanol in rats. Food Sci Biotechnol 23, 2063–2068 (2014). https://doi.org/10.1007/s10068-014-0280-4
- Opuntia ficus indica
- psychomotor alteration