Alleviating effects of Opuntia ficus indica extracts on psychomotor alterations induced by ethanol in rats


Effects of Opuntia ficus indica (OFI) extracts on ethanol-induced psychomotor alterations were studied using Sprague-Dawley rats orally administered 4 g/kg of ethanol (EtOH group) or distilled water (control group). An OFI-group received OFI extracts (50, 100, and 200 mg/kg) 30 min prior to EtOH administration. Behavioral and hematological tests were evaluated 1, 2, 4, and 8 h after EtOH administration. Electroencephalogram (EEG) assessment was also performed. EtOH significantly (p<0.001) induced psychomotor alterations (reduced locomotion, balance, coordination, muscle strength, and tolerance to cold), compared with control group rats. Pre-treatment with OFI extracts alleviated alterations and also inhibited elevation of blood ethanol levels. EEG (percent of total power for delta, theta, alpha, and beta) results for OFI group rats were similar to control rats, indicating a countering of EtOHinduced EEG changes. Extracts of OFI can be effective for alleviation of psychomotor alterations induced by EtOH administration.

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Correspondence to Jae Hoon Cheong.

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dela Peña, I.J.I., Yoon, S.Y., Kim, H.J. et al. Alleviating effects of Opuntia ficus indica extracts on psychomotor alterations induced by ethanol in rats. Food Sci Biotechnol 23, 2063–2068 (2014).

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  • Opuntia ficus indica
  • ethanol
  • psychomotor alteration
  • electroencephalogram