Skip to main content
SpringerLink
Log in

Eleutheroside E, an active compound from Eleutherococcus senticosus, regulates adipogenesis in 3T3-L1 cells

  • Research Article
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

In this study, we investigated the anti-adipogenic effects of Eleutherococcus senticosus and its active compounds in vitro to examine new functions. We first analyzed the active compounds in E. senticosus growing in Korea using HPLC and found that the concentration of eleutheroside B and E was higher in stems and roots than in other plant parts. There were no significant (p<0.05) differences in eleutheroside concentration between plant ages. Anti-adipogenic effects of E. senticosus on lipid accumulation in 3T3-L1 cells were examined. Extracts of stems and roots more effectively inhibited lipid accumulation in 3T3-L1 cells than extracts of other plant parts. Eleutheroside E was responsible for the pharmacological anti-adipogenic effects via regulation of the mTOR pathway. This is the first report of an anti-adipogenic effect of E. senticosus and the active compound eleutheroside E.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Brekhman II, Dardymov IV. New substances of plant origin which increase nonspecific resistance. Ann. Rev. Pharmacol. 9: 419–430 (1969)

    Article  CAS  Google Scholar 

  2. Davydov M, Krikorian AD. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: A closer look. J. Ethnopharmacol. 72: 345–393 (2000)

    Article  CAS  Google Scholar 

  3. Huang L, Zhao H, Huang B, Zheng C. Peng W. Qin L. Acanthopanax senticosus: Review of botany, chemistry and pharmacology. Pharmazie 66: 83–97 (2011)

    CAS  Google Scholar 

  4. Zaluski D, Smolarz HD, Szpilewska M. Eleutherosides in aerial parts of Eleutherococcus species cultivated in Poland. J. AOAC. Int. 94: 1422–1426 (2011)

    Article  CAS  Google Scholar 

  5. Zhang N, Van Crombruggen K, Holtappels G, Bachert C. A herbal composition of scutellaria baicalensis and Eleutherococcus senticosus shows potent anti-inflammatory effects in an ex vivo human mucosal tissue model. Evid. Based Complement. Alternat. Med. 2012: 673145 (2012)

  6. Yu CY, Kim SH, Lim JD, Kim MJ, Chung IM. Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in Eleutherococcus senticosus. Toxicol. In Vitro 17: 229–236 (2003)

    Article  CAS  Google Scholar 

  7. Niu HS, Liu IM, Cheng JT, Lin CL, Hsu FL. Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocininduced diabetic rats. Planta Med. 74: 109–113 (2008)

    Article  CAS  Google Scholar 

  8. Lee S, Shin DS, Oh KB, Shin KH. Antibacterial compounds from the leaves of Acanthopanax senticosus. Arch. Pharm. Res. 26: 40–42 (2003)

    Article  CAS  Google Scholar 

  9. Jung CH, Jung H, Shin YC, Park JH, Jun CY, Kim HM, Yim HS, Shin MG, Bae HS, Kim SH, Ko SG. Eleutherococcus senticosus extract attenuates LPS-induced iNOS expression through the inhibition of Akt and JNK pathways in murine macrophage. J. Ethnopharmacol. 113: 183–187 (2007)

    Article  CAS  Google Scholar 

  10. Hwang JS, Kim SJ, Kim HB. Development and industry of health functional food in Korea. Food Sci. Technol. Res. 15: 1–4 (2009)

    Article  Google Scholar 

  11. Sun YL, Liu LD, Honag SK. Eleutherococcus senticosus as a crude medicine: Review of biological and pharmacological effects. J. Med. Plants Res. 5: 5946–5952 (2011)

    CAS  Google Scholar 

  12. Baczek K. Accumulation of biological active compounds in Eleuthero (Eleutherococcus senticosus/Rupr. et Maxim./Maxim.) grown in Poland. Herba Polonia 55: 7–13 (2009)

    CAS  Google Scholar 

  13. Nishibe S, Kinoshita H, Takeda H, Okano G. Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chem. Pharm. Bull. 38: 1763–1765 (1990)

    Article  CAS  Google Scholar 

  14. Laplante M, Sabatini DM. An emerging role of mTOR in lipid biosynthesis. Curr. Biol. 19: R1046–R1052 (2009)

    Article  CAS  Google Scholar 

  15. Bakan I, Laplante M. Connecting mTORC1 signaling to SREBP-1 activation. Curr. Opin. Lipidol. 23: 226–234 (2012)

    Article  CAS  Google Scholar 

  16. Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4: 648–657 (2002)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divisions of Metabolism and Functionality Research, Korea Food Research Institute, Seongnam, Gyeonggi, 463-746, Korea

    Chang Hwa Jung, Jiyun Ahn & Tae-Youl Ha

  2. Korea Health Supplement Institute, Seongnam, Gyeonggi, 463-400, Korea

    Seok Hyun Heo

Authors
  1. Chang Hwa Jung
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiyun Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Seok Hyun Heo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tae-Youl Ha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tae-Youl Ha.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jung, C.H., Ahn, J., Heo, S.H. et al. Eleutheroside E, an active compound from Eleutherococcus senticosus, regulates adipogenesis in 3T3-L1 cells. Food Sci Biotechnol 23, 889–893 (2014). https://doi.org/10.1007/s10068-014-0119-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-014-0119-z

Keywords

Search

Navigation