Turmeric (Curcuma longa) whole powder reduces accumulation of visceral fat mass and increases hepatic oxidative stress in rats fed a high-fat diet
- First Online:
- 270 Downloads
Turmeric powder (TP) containing approximately 5.15% curcumin was evaluated for reduction of development of high-fat diet-induced obesity. Rats were fed a 30% fat diet containing 5, 10, and 20 g of TP/100 g of diet (TP-5, TP-10, and TP-20 groups) for 30 days. Body weight gain, energy intake, and the visceral fat mass for the TP-10 and TP-20 groups were lower than for the control group. Serum triglyceride and hepatic total lipid levels for the TP-10 and TP-20 groups were lower than for the control group. The hepatic glutathione concentration and the glutathione-S-transferase activity for all TP groups, and the thiobarbituric acid reactive substances level for the TP-20 group, were higher than for the control group. A high dose of turmeric powder apparently reduces development of high-fat diet-induced obesity, but also causes the adverse effect of increasing oxidative stress in rats.
Keywordscurcumin food intake high-fat diet obesity turmeric
Unable to display preview. Download preview PDF.
- 6.Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee RK. Turmeric and curcumin: Biological actions and medicinal applications. Curr. Sci. 87: 44–53 (2004)Google Scholar
- 10.Asai A, Miyazawa T. Dietary curcuminoids prevent high-fat dietinduced lipid accumulation in rat liver and epididymal adipose tissue. J. Nutr. 131: 2932–2935 (2001)Google Scholar
- 13.Joint FAO/ WHO Expert Committee on Food Additives. Specifications for the identity and purity of some extractions solvents and certain other substances, FAO Nutrition Meeting, Report Series No. 48B, WHO/Food Add/70.40. FAO and WHO, Geneva, Switzerland (1971)Google Scholar
- 16.Yang KY, Lin LC, Tseng TY, Wang SC, Tsai TH. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J. Chromatogr. B Technol. Biomed. Life Sci. 853: 183–189 (2007)Google Scholar
- 17.AOAC. Official Method of Analysis of AOAC Intl. 15th ed. Method 920.87, 920.85, 925.10, 923.03. Association of Official Analytical Communities, Arlington, VA, USA (1990)Google Scholar
- 18.National Research Council. Guide for the care and use of laboratory animals. Available from: http://newton.nap.edu/html/labrats. Accessed Dec. 27, 2011.
- 19.Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497–509 (1957)Google Scholar
- 21.Habig WH, Pabst MJ, Jakoby WB. Glutathione-S-transferases. J. Biol. Chem. 249: 7130–7139 (1974)Google Scholar
- 24.Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265–275 (1951)Google Scholar
- 28.Gajda AM, Pellizzon MA, Ricci MR, Ulman EA. Diet-induced metabolic syndrome in rodent models. Available from: http://www.researchdiets.com/OSD/DIDM/metabolic.htm. Accessed Apr. 21, 2013.