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Japanese apricot extract attenuates nuclear factor-κB activation and proteasomal activity in A549 lung cancer cells

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Abstract

The present study investigated the mechanism of Japanese apricot extract (JAE) in inhibiting lung cancer cells proliferation. JAE inhibited A549 lung cancer cell proliferation at non-cytotoxic doses and suppressed nuclear factor-κB (NF-κB) activation induced by TNF-α at a dose of 1 mg/mL (p<0.05). Proteasome activities of A549 cells were blocked by JAE in a dose-dependent manner at concentrations of 0.67 and 1 mg/mL (p<0.05). These results indicate that JAE has anti-proliferative activity against A549 cells and suppresses NF-κB activation, partially due to inhibiting proteasome activity.

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Authors and Affiliations

  1. Department of Food and Nutrition, Sungshin Women’s University, Seoul, 142-732, Korea

    Hyungeun Yoon

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  1. Hyungeun Yoon
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Correspondence to Hyungeun Yoon.

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Yoon, H. Japanese apricot extract attenuates nuclear factor-κB activation and proteasomal activity in A549 lung cancer cells. Food Sci Biotechnol 21, 1507–1510 (2012). https://doi.org/10.1007/s10068-012-0200-4

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  • DOI: https://doi.org/10.1007/s10068-012-0200-4

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