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Food Science and Biotechnology

, Volume 21, Issue 5, pp 1501–1506 | Cite as

Arabinogalactan-type polysaccharides (APS) from Cordyceps militaris grown on germinated soybeans (GSC) induces innate immune activity of THP-1 monocytes through promoting their macrophage differentiation and macrophage activity

  • Dong Ki Park
  • Toshimitsu Hayashi
  • Hye-Jin ParkEmail author
Research Note

Abstract

In this study, the immunemodulatory activities of arabinogalactans-type polysaccharide (APS) from Cordyceps militaris grown on germinated soybeans was evaluated in THP-1 human monocytes. The cellular size and the number of intracellular organelles of THP-1 monocytes were increased by APS. Also, APS-treated THP-1 cells significantly developed cellular adherence and macrophagic differentiation to the culture plate surface. APS noticeably enhanced phagocytic activity of THP-1 cells against IgG-FITC-latex beads. APS induced the level of TNF-α, IL-12 p40, and IL-8 as well as TLR2 and TLR4 mRNAs. APS can be developed as a promising immunmodulating agent with macrophage-activating properties.

Keywords

arabinogalactans-type polysaccharide (APS) innate immunity phagocytosis macrophage differentiation THP-1 monocyte 

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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Dong Ki Park
    • 1
    • 2
  • Toshimitsu Hayashi
    • 3
  • Hye-Jin Park
    • 1
    Email author
  1. 1.Department of Bioscience and BiotechnologyKonkuk UniversitySeoulKorea
  2. 2.Cell Activation Research Institute (CARI)Konkuk UniversitySeoulKorea
  3. 3.Graduate School of Medicine and Pharmaceutical Sciences for ResearchUniversity of ToyamaSugitani, ToyamaJapan

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