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Arabinogalactan-type polysaccharides (APS) from Cordyceps militaris grown on germinated soybeans (GSC) induces innate immune activity of THP-1 monocytes through promoting their macrophage differentiation and macrophage activity

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Abstract

In this study, the immunemodulatory activities of arabinogalactans-type polysaccharide (APS) from Cordyceps militaris grown on germinated soybeans was evaluated in THP-1 human monocytes. The cellular size and the number of intracellular organelles of THP-1 monocytes were increased by APS. Also, APS-treated THP-1 cells significantly developed cellular adherence and macrophagic differentiation to the culture plate surface. APS noticeably enhanced phagocytic activity of THP-1 cells against IgG-FITC-latex beads. APS induced the level of TNF-α, IL-12 p40, and IL-8 as well as TLR2 and TLR4 mRNAs. APS can be developed as a promising immunmodulating agent with macrophage-activating properties.

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology, Konkuk University, Seoul, 143-701, Korea

    Dong Ki Park & Hye-Jin Park

  2. Cell Activation Research Institute (CARI), Konkuk University, Seoul, 143-701, Korea

    Dong Ki Park

  3. Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630, Sugitani, Toyama, 930-0194, Japan

    Toshimitsu Hayashi

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  1. Dong Ki Park
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  2. Toshimitsu Hayashi
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  3. Hye-Jin Park
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Correspondence to Hye-Jin Park.

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Park, D.K., Hayashi, T. & Park, HJ. Arabinogalactan-type polysaccharides (APS) from Cordyceps militaris grown on germinated soybeans (GSC) induces innate immune activity of THP-1 monocytes through promoting their macrophage differentiation and macrophage activity. Food Sci Biotechnol 21, 1501–1506 (2012). https://doi.org/10.1007/s10068-012-0199-6

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  • DOI: https://doi.org/10.1007/s10068-012-0199-6

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