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Myricetin inhibits adipogenesis in human adipose tissue-derived mesenchymal stem cells

Food Science and Biotechnology volume 21, pages 1391–1396 (2012)Cite this article

Abstract

Myricetin is a major flavonoid found in various foods that has antioxidant, anti-inflammatory, and anticancer effects. Although the functional effects of myricetin in various cell types are well characterized, it is not known whether myricetin has an effect on stem cell differentiation. In this study, we demonstrate that myricetin inhibits adipogenesis in human adipose tissue-derived mesenchymal stem cells, as indicated by decreased accumulation of intracellular lipid droplets. The mRNA levels of CCAATenhancer-binding proteins (C/EBP)-α, peroxisome proliferator-activated receptor-γ (PPAR-γ), lipoprotein lipase, fatty acid binding protein (aP2), and adiponectin decreased significantly following treatment with 30 μM myricetin. C/EBP-α expression was inhibited from the beginning of differentiation in response to the myricetin treatment. PPAR-α was significantly inhibited beginning at day 9. These results suggest a novel effect of myricetin on adipocyte differentiation in human adipose tissue-derived mesenchymal stem cells and the possibility that myricetin might affect the differentiation of other types of stem cells.

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Authors and Affiliations

  1. Food Science Lab., Department of Food Science & Technology, Korea National University of Transportation, Jeungpyeong, Chungbuk, 368-701, Korea

    Hee-Shin Bin & Ung-Kyu Choi

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  1. Hee-Shin Bin
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  2. Ung-Kyu Choi
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Correspondence to Ung-Kyu Choi.

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Bin, HS., Choi, UK. Myricetin inhibits adipogenesis in human adipose tissue-derived mesenchymal stem cells. Food Sci Biotechnol 21, 1391–1396 (2012). https://doi.org/10.1007/s10068-012-0183-1

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  • DOI: https://doi.org/10.1007/s10068-012-0183-1

Keywords

  • myricetin
  • human adipose tissue-derived mesenchymal stem cell
  • adipogenesis