Food Science and Biotechnology

, Volume 21, Issue 5, pp 1235–1241 | Cite as

Chaga mushroom (Inonotus obliquus) grown on germinated brown rice suppresses inflammation associated with colitis in mice

  • Trishna Debnath
  • Md. Abul Hasnat
  • Mehnaz Pervin
  • Seung Yuan Lee
  • Sa Ra Park
  • Da Hye Kim
  • Hyuk Jung Kweon
  • Jong Moon Kim
  • Beong Ou LimEmail author
Research Article


The aim of this study was to evaluate the antiinflammatory activity of ethanol extracts from chaga mushroom (Inonotus obliquus, IOE) grown on germinated brown rice. A total of 35 male BALB/c mice were divided into 5 treatment groups and given a commercial diet (A), IOE administration (B), dextran sodium sulfate (DSS) treatment to induce colitis (C), IOE administration+DSSinduced colitis (D), and sulfasalazine administration+ DSS-induced colitis (E). IOE treatment (D) decreased the expression of tumor necrosis factor (TNF)-α, cyclooxygenase (COX)-2, interleukin (IL)-4, interferon (IFN)-γ, signal transducers and activators of transcription (STAT)1, and STAT6 and showed lower levels of immunoglobulin (Ig)E and IgA in the spleen and mesenteric lymph node (MLN) compared to those of the DSS-induced colitis group (C). In addition, IOE suppressed the DSS-induced colonic tissue destruction. Therefore, our data strongly suggests that IOE could be a potent anti-inflammatory agent.


inflammatory bowel disease Crohn’s disease ulcerative colitis 


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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Trishna Debnath
    • 1
  • Md. Abul Hasnat
    • 1
  • Mehnaz Pervin
    • 1
  • Seung Yuan Lee
    • 1
  • Sa Ra Park
    • 1
  • Da Hye Kim
    • 1
  • Hyuk Jung Kweon
    • 2
    • 4
  • Jong Moon Kim
    • 3
    • 4
  • Beong Ou Lim
    • 1
    • 4
    Email author
  1. 1.College of Biomedical & Health Science, Department of Life ScienceKonkuk UniversityChungju, ChungbukKorea
  2. 2.Department of Family MedicineKonkuk UniversityChungju, ChungbukKorea
  3. 3.Rehabilitation MedicineKonkuk University, Chungju HospitalChungju, ChungbukKorea
  4. 4.Research Institute of Inflammatory DiseaseKonkuk UniversityChungju, ChungbukKorea

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