The effects of oral administration of nutmeg extract (NE) on atopic dermatitis (AD) were evaluated using NC/Nga mice treated with American house dust mite (Dermatophagoides farinae) extract. In this mouse model of AD, NE suppressed transepidermal water loss, erythema, and the production of serum immunoglobulin E, interleukin (IL)-4, and interferon-γ by auxillary lymph node cells. In addition, NE reduced epidermal thickening and inflammatory cell infiltration into the skin. In skin lesions, NE suppressed IL-13 and tumor necrosis factor (TNF)-α mRNA expression. In the spleen, NE upregulated T-box transcription factor expressed in T cells and downregulated GATA-binding protein 3, which are involved in T helper cell differentiation. Our findings suggest that NE ameliorates AD and may be a potential nutraceutical candidate for treating AD.
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Leung DYM, Bieber T. Atopic dermatitis. Lancet 361: 151–160 (2003)
Turner JD, Schwartz RA. Atopic dermatitis. A clinical challenge. Acta Dermatovenerol. Alp. Panonica Adriat. 15: 59–68 (2006)
Bieber T. Mechanisms of disease atopic dermatitis. New Engl. J. Med. 358: 1483–1494 (2008)
Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J. Clin. Invest. 113: 651–657 (2004)
Grogan JL, Locksley RM. T helper cell differentiation: On again, off again. Curr. Opin. Immunol. 14: 366–372 (2002)
Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher LH. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655–669 (2000)
Oranje AP. Atopic dermatitis: Review 2000 to January 2001. Curr. Opin. Pediatr. 14: 410–413 (2002)
Seidenari S, Giusti G. Objective assessment of the skin of children affected by atopic dermatitis: A study of pH, capacitance, and TEWL in eczematous and clinically uninvolved skin. Acta Derm. Venereol. 75: 429–433 (1995)
Olajide OA, Ajayi FF, Ekhelar AI, Awe SO, Makinde JM, Alada AR. Biological effects of Myristica fragrans (nutmeg) extract. Phytother. Res. 13: 344–345 (1999)
Chung JY, Choo JH, Lee MH, Hwang JK. Anticariogenic activity of macelignan isolated from Myristica fragrans (nutmeg) against Streptococcus mutans. Phytomedicine 13: 261–266 (2006)
Kim DU. Antibacterial activity against Propionibacterium acnes and anti-inflammatory activity of macelignan isolated from Myristica fragrans. PhD thesis, Yonsei University, Seoul, Korea (2004)
Yamamoto M, Haruna T, Yasui K, Takahashi H, Iduhara M, Takaki S, Deguchi M, Arimura A. A novel atopic dermatitis model induced by topical application with Dermatophagoides farinae extract in NC/Nga mice. Allergol. Int. 56: 139–148 (2007)
Beck LA, Leung DY. Allergen sensitization through the skin induces systemic allergic responses. J. Allergy Clin. Immun. 106: S258–S263 (2000)
Mamessier E, Magnan A. Cytokines in atopic diseases: Revisiting the Th2 dogma. Eur. J. Dermatol. 16: 103–113 (2006)
Ying S, Meng Q, Barata LT, Robinson DS, Durham SR, Kay AB. Associations between IL-13 and IL-4 (mRNA and protein), vascular cell adhesion molecule-1 expression, and the infiltration of eosinophils, macrophages, and T cells in allergen-induced late-phase cutaneous reactions in atopic subjects. J. Immunol. 158: 5050–5057 (1997)
Chakir H, Wang H, Lefebvre DE, Webb J, Scott FW. T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: Predominant role of GATA-3. J. Immunol. Methods 278: 157–169 (2003)
Barnes PJ. Role of GATA-3 in allergic diseases. Curr. Mol. Med. 8: 330–334 (2008)
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Chung, HC., Kim, MS., Mun, SY. et al. Effect of oral administration of nutmeg extract on american house dust mite (Dermatophagoides farinae) extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Food Sci Biotechnol 21, 559–564 (2012). https://doi.org/10.1007/s10068-012-0071-8
- nutmeg (Myristica fragrans Houtt)
- atopic dermatitis
- Dermatophagoides farinae extract
- NC/Nga mice