Skip to main content
SpringerLink
Log in

Anticancer, antioxidant, and antimicrobial activities of anemone (Anemone cathayensis)

  • Research Article
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

This study was performed to evaluate the anticancer, antioxidant, and antimicrobial activities of fractions and isolated compounds from anemone (Anemone cathayensis). Fourteen compounds were isolated from extracts. Anticancer activities of fractions and compounds were determined by MTT assay, and all tested fractions showed inhibition activity on human breast cancer cells (MDA-MB-231). The fraction 6 displayed the strongest anticancer activity, and inhibition percent was 50.32%. The antioxidant effect of fractions was evaluated by using DPPH scavenging assays. Fraction 5 had a higher DPPH radical scavenging activity with low IC50 value of 30.578 μg/mL. The antimicrobial activity of the fractions was evaluated against 3 microorganisms using the agar well diffusion method. The fractions also showed moderate antimicrobial activity. These results suggest that anemone could hold a good potential source for human health.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mehta S, Rai PK, Rai DK, Rai NK, Rai AK, Bicanic D, Sharma B, Watal G. LIBS-based detection of antioxidant elements in seeds of Emblica officinalis. Food Biophys. 5: 186–192 (2010)

    Article  Google Scholar 

  2. Rai PK, Jaiswal D, Rai DK, Sharma B, Watal G. Antioxidant potential of oral feeding of Cynodon dactylon extract on diabetes induced oxidative stress. J. Food Biochem. 34: 78–92 (2010)

    Article  CAS  Google Scholar 

  3. Sharma RK, Chatterji S, Rai DK, Mehta S, Rai PK, Singh RK, Watal G, Sharma B. Antioxidant activities and phenolic contents of the aqueous extracts of some Indian medicinal plants. J. Med. Plants Res. 3: 944–948 (2009)

    CAS  Google Scholar 

  4. Flora of China Editorial Committee of Chinese Academy of Sciences. Flora of China. Vol. 30. Science Press, Beijing, China. p. 54 (2004)

    Google Scholar 

  5. Lu JC, Xu BB, Zhang XY, Sun QS. Study on chemical constituents of rhizome of Anemone raddeana. Acta Pharm. Sin. 37: 709–712 (2002)

    CAS  Google Scholar 

  6. Xia ZT, Liu DY, Wang XY, Liu KF, Zhang PC. Studies on the chemical constituents of the rhizoma of Anemone raddeana Regel. Acta Chim. Sinica 62: 1935–1940 (2004)

    CAS  Google Scholar 

  7. Zhang QW, Ye WC, Che CT, Zhapo SX. Studies on the chemical constituents from Anemone anhuiensis YK Yang N. Wang et W. C. Ye. China J. Chinese Mater. Med. 9: 36–38 (2001)

    CAS  Google Scholar 

  8. Liao X, Chen YZ, Ding LS, Li BG. Chemical constituents from Aanemone rupestris ssp. Gelida. Natural Product Res. Develop. 4: 1–6 (1999)

    Google Scholar 

  9. Wang MK, Ding LS, Wu FE. Antitumor effects of raddeanin A on S180, H22, and U14 cell xenografts in mice. Chinese J. Cancer 27: 910–913 (2008)

    CAS  Google Scholar 

  10. Peng SL, Liao X, Wang FT, Ding LS. Antitumor effect of the saponins from Anemone davidii. Natural Product Res. Develop. 5: 60–62 (2001)

    Google Scholar 

  11. Khan N, Hadi N, Afaq F, Syed DN, Kweon MH, Mukhtar H. Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis 28: 163–173 (2007)

    Article  CAS  Google Scholar 

  12. Kirby AJ, Schmidt RJ. The antioxidant activity of Chinese herbs for eczema and of placebo herbs — I. J. Ethnopharmacol. 56: 103–108 (1997)

    Article  CAS  Google Scholar 

  13. Fan ZL, Wang ZY, Cheng CL, Zhao HT, Zhang H. Antioxidant and antiproliferative activities of five wild berries. Food Sci. 31(17): 148–152 (2010)

    Google Scholar 

  14. Song Q, Chai QY, Zhang LW. In vivo anti-tumor activity of total saponins from Asparagus officinalis. Food Sci. 31(13): 273–275 (2010)

    CAS  Google Scholar 

  15. Liu J, David GP, Jing H. Hawthorn flavonoid extract: Antioxidant activity and growth inhibition effect on cancer cells. Food Sci. 31(3): 220–223 (2010)

    CAS  Google Scholar 

  16. Coughlin SS, Ekuweme DU. Breast cancer as a global health concern. Cancer Epidemiol. 33: 315–318 (2009)

    Article  Google Scholar 

  17. Sharma V. A polyphenolic compound rottlerin demonstrates significant in vitro cytotoxicity against human cancer cell lines: Isolation and characterization from the fruits of Mallotus philippinensis. J. Plant Biochem. Biotechnol. 20: 190–195 (2011)

    Article  CAS  Google Scholar 

  18. Allouche Y, Warleta F, Campos M, Sanchez-Quesada, C, Uceda M, Beltran G, Gaforio JJ. Antioxidant, antiproliferative, and proapoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage. J. Agr. Food Chem. 59: 121–130 (2011)

    Article  CAS  Google Scholar 

  19. Finkel T, Holbrook NJ. Oxidants, oxidative stress, and the biology of ageing. Nature 408: 239–247 (2000)

    Article  CAS  Google Scholar 

  20. Wu XJ, Hansen C. Antioxidant capacity, phenolic content, and polysaccharide content of Lentinus edodes grown in whey permeate-based submerged culture. J. Food Sci. 73: 1–8 (2008)

    Article  Google Scholar 

  21. Hsouna AB, Trigui M, Culioli G, Blache Y, Jaoua S. Antioxidant constituents from Lawsonia inermis leaves: Isolation, structure elucidation, and antioxidative capacity. Food Chem. 125: 193–200 (2011)

    Article  Google Scholar 

  22. Erkana N, Cetinb H, Ayranci E. Antioxidant activities of Sideritis congesta Davis et Huber-Morath and Sideritis arguta Boiss et Heldr: Identification of free flavonoids and cinnamic acid derivatives. Food Res. Int. 44: 297–303 (2011)

    Article  Google Scholar 

  23. Hseu YC, Chen SC, Yechd YJ, Wang L, Yang HL. Antioxidant activity of Antrodia camphorate on free radical-induced endothelial cell damage. J. Ethnopharmacol. 118: 237–245 (2008)

    Article  Google Scholar 

  24. Cho ML, Lee HS, Kang IJ, Wond MH, You SG. Antioxidant properties of extract and fractions from Enteromorpha prolifera, a type of green seaweed. Food Chem. 127: 999–1006 (2011)

    Article  CAS  Google Scholar 

  25. Cui Yh, Zhang KC. Assessment of in vitro antioxidant activity of a triterpenoidal saponin from Ganoderma lucidum fruit bodiese). Food Sci. 31(19): 49–53 (2010)

    CAS  Google Scholar 

  26. Murthy PS, Manonmani HK. Physico-chemical, antioxidant, and antimicrobial properties of Indian monsooned coffee. Eur. Food Res. Technol. 229: 645–650 (2009)

    Article  CAS  Google Scholar 

  27. Liao X, Li BG, Gao XP, Guan JF, Ding LS, Chen YZ. Bioactive triterpenoid saponins from Anemone davidii. Chinese Trad. Herbal Drugs 32(6): 15–18 (2001)

    Google Scholar 

  28. Kim H, Choi HK, Moon JY, Kim YS, Mosaddik A, Cho SK. Comparative antioxidant and antiproliferative activities of red and white pitayas and their correlation with flavonoid and polyphenol content. J. Food Sci. 76: 38–45 (2011)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Life and Environmental Sciences, Minzu University of China, Beijing, 100081, China

    Jun-li Wang, Kun Liu, Wei-zhen Gong, Qian Wang, Dong-ting Xu, Ming-fei Liu, Kai-li Bi & Yun-fei Song

  2. College of Biology Science and Engineering, Hebei University of Economics and Business, Shijiazhuang, 050061, China

    Kun Liu

Authors
  1. Jun-li Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kun Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wei-zhen Gong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Qian Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dong-ting Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ming-fei Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Kai-li Bi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yun-fei Song
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun-li Wang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, Jl., Liu, K., Gong, Wz. et al. Anticancer, antioxidant, and antimicrobial activities of anemone (Anemone cathayensis). Food Sci Biotechnol 21, 551–557 (2012). https://doi.org/10.1007/s10068-012-0070-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-012-0070-9

Keywords

Search

Navigation