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Safety evaluation of refined cuttlefish (Todarodes pacificus) oil

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Abstract

Genetic toxicity of the refined cuttlefish (Todarodes pacificus) oil (CFO) was assessed through a reverse mutation (RM) test, chromosome aberration (CA) test, and micronucleus (MN) test to confirm the safety of the CFO for a functional ingredient. Five strains (TA98, TA100, TA1535, TA1537, and WP2uvrA) were used for the RM test. In metaphase analysis with and without S9 mix, colonies of all the dosed groups were not increased up to 2 times, compared to that of the negative control. The frequencies of numerical and structural CA by the CFO were not significantly different from those of the negative control. The frequency of micronucleated erythrocyte among polychromatic erythrocytes in all dosed groups was not significantly different from that of the negative control and the CFO did not induce the inhibition of erythrocyte-growth. Also, no dose-dependence was found in every test. In conclusion, the refined CFO had no genetic toxicity because no positive reaction was found through the RM, CA, and MN tests.

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Authors and Affiliations

  1. Department of Food and Nutrition, Dankook University, Yongin, Gyeonggi, 448-160, Korea

    Joung-Hyun Park

  2. R&D Center of Dong Woo Industrial Co., Ltd., Pohang, Gyeongbuk, 790-804, Korea

    Joung-Hyun Park, Heon Lee, Geun-Yong Lee, Hye-Ran Kim & Young-Woo Kim

  3. Center for Biosafety, Catholic University of Daegu, Gyeongsan, Gyeongbuk, 712-702, Korea

    Yeong-Chul Park

  4. Department of Food and Nutrition, Silla University, Busan, 617-736, Korea

    Mihyang Kim

  5. Department of Food Science and Technology, Pukyoung National University, Busan, 608-737, Korea

    Yang-Bong Lee

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  1. Joung-Hyun Park
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  2. Yeong-Chul Park
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Correspondence to Joung-Hyun Park.

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Park, JH., Park, YC., Lee, H. et al. Safety evaluation of refined cuttlefish (Todarodes pacificus) oil. Food Sci Biotechnol 20, 905–912 (2011). https://doi.org/10.1007/s10068-011-0125-3

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