The anti-diabetic potential of watermelon (Citrullus vulgaris Schrad) was evaluated in vivo. ICR mice were fed experimental diet containing none, 10% watermelon flesh powder (WM-P) or 1% watermelon rind ethanol extract (WM-E). At the end of 4 weeks, mice were administrated with streptozotocin (40 mg/kg, i.p.) for 5 consecutive days to induce diabetes. Supplementation with WM-E significantly decreased blood glucose level and increased serum insulin levels. Feeding of WM-P also induced moderate changes but those were not statistically significant. Immunohistochemical analysis showed watermelon effectively protected pancreatic cells death. These results suggest that watermelon has a beneficial effect on diabetes.
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Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabet. Med. 14(Suppl. 5): S1–S85 (1997)
Rakieten N, Rakieten ML, Nadkarni MV. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemoth. Rep. 29: 91–98 (1963)
Bhattacharya G. On the protection against alloxan diabetes by hexoses. Science 120: 841–843 (1954)
Schein PS, Rakieten N, Cooney DA, Davis R, Vernon ML. Streptozotocin diabetes in monkeys and dogs, and its prevention by nicotinamide. Proc. Soc. Exp. Biol. Med. 143: 514–518 (1973)
Matkovics B, Kotorman M, Varga IS, Hai DQ, Varga C. Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol. Hung. 85: 29–38 (1997)
Rimando AM, Perkins-Veazie PM. Determination of citrulline in watermelon rind. J. Chromatogr. A 1078: 196–200 (2005)
Haslam DW, James WP. Obesity. Lancet 366: 1197–1209 (2005)
Wu G, Morris SM Jr. Arginine metabolism: Nitric oxide and beyond. Biochem. J. 336(Pt. 1): 1–17 (1998)
Kohli R, Meininger CJ, Haynes TE, Yan W, Self JT, Wu G. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J. Nutr. 134: 600–608 (2004)
Bohm V, Puspitasari-Nienaber NL, Ferruzzi MG, Schwartz SJ. Trolox equivalent antioxidant capacity of different geometrical isomers of α-carotene, β-carotene, lycopene, and zeaxanthin. J. Agr. Food Chem. 50: 221–226 (2002)
Holden JM EA, Beecher GR, Marilyn Buzzard I, Bhagwat S, Davis CS, Douglass LW, Gebhardt SG, Haytowitz D, Schakel S. Carotenoid content of U.S. foods: An update of the database. J. Food Compos. Anal. 12: 28–30 (1999)
Sandalio LM, Lopez-Huertas E, Bueno P, Del Rio LA. Immunocytochemical localization of copper, zinc superoxide dismutase in peroxisomes from watermelon (Citrullus vulgaris Schrad.) cotyledons. Free Radical Res. 26: 187–194 (1997)
Wu G, Collins JK, Perkins-Veazie P, Siddiq M, Dolan KD, Kelly KA, Heaps CL, Meininger CJ. Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats. J. Nutr. 137: 2680–2685 (2007)
Rafi MM, Yadav PN, Reyes M. Lycopene inhibits LPS-induced proinflammatory mediator inducible nitric oxide synthase in mouse macrophage cells. J. Food Sci. 72: S069–S074 (2007)
Dhanotia R, Chauhan NS, Saraf DK, Dixit VK. Effect of Citrullus colocynthis Schrad fruits on testosterone-induced alopecia. Nat. Prod. Res. 16: 1–12 (2009)
Daradka H, Almasad MM, Qazan W, El-Banna NM, Samara OH. Hypolipidaemic effects of Citrullus colocynthis L. in rabbits. Pak. J. Biol. Sci. 10: 2768–2771 (2007)
Ojewole JA. Hypoglycemic effect of Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark aqueous extract in rats. Phytomedicine 10: 675–681 (2003)
Ignarro LJ, Cirino G, Casini A, Napoli C. Nitric oxide as a signaling molecule in the vascular system: An overview. J. Cardiovasc. Pharmacol. 34: 879–886 (1999)
Collins JK, Wu G, Perkins-Veazie P, Spears K, Claypool PL, Baker RA, Clevidence BA. Watermelon consumption increases plasma arginine concentrations in adults. Nutrition 23: 261–266 (2007)
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Ahn, J., Choi, W., Kim, S. et al. Anti-diabetic effect of watermelon (Citrullus vulgaris Schrad) on Streptozotocin-induced diabetic mice. Food Sci Biotechnol 20, 251–254 (2011). https://doi.org/10.1007/s10068-011-0034-5
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