Anti-diabetic effect of watermelon (Citrullus vulgaris Schrad) on Streptozotocin-induced diabetic mice
- 331 Downloads
The anti-diabetic potential of watermelon (Citrullus vulgaris Schrad) was evaluated in vivo. ICR mice were fed experimental diet containing none, 10% watermelon flesh powder (WM-P) or 1% watermelon rind ethanol extract (WM-E). At the end of 4 weeks, mice were administrated with streptozotocin (40 mg/kg, i.p.) for 5 consecutive days to induce diabetes. Supplementation with WM-E significantly decreased blood glucose level and increased serum insulin levels. Feeding of WM-P also induced moderate changes but those were not statistically significant. Immunohistochemical analysis showed watermelon effectively protected pancreatic cells death. These results suggest that watermelon has a beneficial effect on diabetes.
Keywordswatermelon (Citrullus vulgaris Schrad) antidiabetic streptozotocin insulin
Unable to display preview. Download preview PDF.
- 1.Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabet. Med. 14(Suppl. 5): S1–S85 (1997)Google Scholar
- 2.Rakieten N, Rakieten ML, Nadkarni MV. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemoth. Rep. 29: 91–98 (1963)Google Scholar
- 4.Schein PS, Rakieten N, Cooney DA, Davis R, Vernon ML. Streptozotocin diabetes in monkeys and dogs, and its prevention by nicotinamide. Proc. Soc. Exp. Biol. Med. 143: 514–518 (1973)Google Scholar
- 5.Matkovics B, Kotorman M, Varga IS, Hai DQ, Varga C. Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol. Hung. 85: 29–38 (1997)Google Scholar
- 8.Wu G, Morris SM Jr. Arginine metabolism: Nitric oxide and beyond. Biochem. J. 336(Pt. 1): 1–17 (1998)Google Scholar
- 9.Kohli R, Meininger CJ, Haynes TE, Yan W, Self JT, Wu G. Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats. J. Nutr. 134: 600–608 (2004)Google Scholar
- 13.Wu G, Collins JK, Perkins-Veazie P, Siddiq M, Dolan KD, Kelly KA, Heaps CL, Meininger CJ. Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats. J. Nutr. 137: 2680–2685 (2007)Google Scholar