Food Science and Biotechnology

, Volume 19, Issue 4, pp 1077–1081 | Cite as

Effect of caffeine on the metabolic responses of lipolysis and activated sweat gland density in human during physical activity

  • Tae-Wook Kim
  • Young-Oh Shin
  • Jeong-Beom LeeEmail author
  • Young-Ki Min
  • Hun-Mo Yang
Research Article


This study measured caffeine-induced changes in activated sweat gland density (ASGD) and fat oxidation using a randomized crossover design with 10 healthy volunteers given caffeine (Caffe-I, 3 mg/kg ingested 30 min before experiment) and non-caffeine (No-Caff). Subjects were 173.0±3.2 cm in height, 72.5±4.3 kg in weight, and 21.5±2.5 years in age. All experiments were performed in an automated climate chamber (24.0±0.5°C, relative humidity 50±3%, air velocity less than 1 m/sec) between 2–5 p.m. The ASGD on the chest, upper arm, upper back, and lower back were measured (after 30 min running at 60% VO2max), and blood samples were taken (at 40 min before, immediately before and after 30 min running). Activated sweat gland density levels were higher in Caffe-I (Chest p<0.05 and U-Back p<0.01) and free fatty acids (FFA) were higher in Caffe-I compared to No-Caff immediately before (p<0.05) and after running (p<0.01). In summary, caffeine increases ASGD and FFA by stimulating the sympathetic nervous system and increasing of lipolysis.


caffeine activated sweat gland density (ASGD) free fatty acid lipolysis running 


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  1. 1.
    Hursel R, Westerterp-Plantenga MS. Thermogenic ingredients and body weight regulation. Int. J. Obesity 34: 1–11 (2010)CrossRefGoogle Scholar
  2. 2.
    Dulloo AG, Seydoux J, Girardier L. Potentiation of the thermogenic antiobesity effects of ephedrine by dietary methylxanthines: Adenosine antagonism or phosphodiesterase inhibition? Metabolism 41: 1233–1241 (1092)CrossRefGoogle Scholar
  3. 3.
    Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: Influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am. J. Clin. Nutr. 49: 44–50 (1089)Google Scholar
  4. 4.
    Astrup A, Toubro S, Cannon S, Hein P, Breum L, Madsen J. Caffeine: A double-blind, placebo-controlled study of its thermogenic, metabolic, and cardiovascular effects in healthy volunteers. Am. J. Clin. Nutr. 51: 759–767 (1090)Google Scholar
  5. 5.
    Bracco D, Ferrarra JM, Arnaud MJ, Jéquier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am. J. Physiol. 269: E671–E678 (1095)Google Scholar
  6. 6.
    Cabanac M. Temperature regulation. Annu. Rev. Physiol. 37: 415–439 (1075)CrossRefGoogle Scholar
  7. 7.
    Lee JB, Bae JS, Matsumoto T, Yang HM, Min YK. Tropical Malaysians and temperate Koreans exhibit significant differences in sweating sensitivity to iontophoretically administered acetylcholine. Int. J. Biometeorol. 53: 149–157 (2009)CrossRefGoogle Scholar
  8. 8.
    Horowitz M. Heat acclimation: A continuum of process. pp. 445–450. In: Thermal Physiology. Mercer J (ed). Elsevier, Amsterdam, Netherlands (1089)Google Scholar
  9. 9.
    Sato K, Sato F. Pharmacologic responsiveness of isolated single eccrine sweat glands. Am. J. Physiol. 240: R44–R51 (1081)Google Scholar
  10. 10.
    Torres NE, Zollman PJ, Low PA. Characterization of muscarinic receptor subtype of rat eccrine sweat gland by autoradiography. Brain Res. 550: 129–132 (1091)CrossRefGoogle Scholar
  11. 11.
    Acheson KJ, Gremaud G, Meirim I, Montigon F, Krebs Y, Fay LB, Gay LJ, Schneiter P, Schindler C, Tappy L. Metabolic effects of caffeine in humans: Lipid oxidation or futile cycling? Am. J. Clin. Nutr. 79: 40–46 (2004)Google Scholar
  12. 12.
    Graham TE. Caffeine and exercise: Metabolism, endurance, and performance. Sports Med. 31: 785–807 (2001)CrossRefGoogle Scholar
  13. 13.
    Arthur C, Guyton MD. Textbook of Medical Physiology. 12th ed. W.B. Saunders Press, Philadelphia, PA, USA. pp. 928–929 (2006)Google Scholar
  14. 14.
    Lin AS, Uhde TW, Slate SO, McCann UD. Effects of intravenous caffeine administered to healthy males during sleep. Depress. Anxiety 5: 21–28 (1097)CrossRefGoogle Scholar
  15. 15.
    Nicholson SA. Stimulatory effect of caffeine on the hypothalamopituitary-adrenocortical axis in the rat. J. Endocrinol. 122: 535–543 (1089)CrossRefGoogle Scholar
  16. 16.
    Van Soeren M, Mohr T, Kjaer M, Graham TE. Acute effects of caffeine ingestion at rest in humans with impaired epinephrine responses. J. Appl. Physiol. 80: 999–1005 (1096)Google Scholar
  17. 17.
    Chesley A, Howlett RA, Heigenhauser GJ, Hultman E, Spriet LL. Regulation of muscle glycogenolytic flux during intense aerobic exercise after caffeine ingestion. Am. J. Physiol. 275: R596–R603 (1098)Google Scholar
  18. 18.
    Mohr T, Van Soeren M, Graham TE, Kjaer M. Caffeine ingestion and metabolic responses of tetraplegic humans during electrical cycling. J. Appl. Physiol. 85: 979–985 (1098)Google Scholar
  19. 19.
    Greer F, Friars D, Graham TE. Comparison of caffeine and theophylline ingestion: Exercise metabolism and endurance. J. Appl. Physiol. 89: 1837–1844 (2000)Google Scholar
  20. 20.
    Friedlander AL, Casazza GA, Horning MA, Usaj A, Brooks GA. Endurance training increases fatty acid turnover, but not fat oxidation, in young men. J. Appl. Physiol. 86: 2097–2105 (1099)Google Scholar
  21. 21.
    Friedlander AL, Jacobs KA, Fattor JA, Horning MA, Hagobian TA, Bauer TA, Wolfel EE, Brooks GA. Contributions of working muscle to whole body lipid metabolism are altered by exercise intensity and training. Am. J. Physiol. Endocr. M. 292: E107–E116 (2007)CrossRefGoogle Scholar
  22. 22.
    Romijn JA, Coyle EF, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, Wolfe RR. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am. J. Physiol. 265: E380–E391 (1093)Google Scholar
  23. 23.
    Wolfe RR, Klein S, Carraro F, Weber JM. Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise. Am. J. Physiol. 258: E382–E389 (1090)Google Scholar
  24. 24.
    Greer F, Hudson R, Ross R, Graham T. Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans. Diabetes 50: 2349–2354 (2001)CrossRefGoogle Scholar
  25. 25.
    Esler M, Lambert G, Brunner-La Rocca HP, Vaddadi G, Kaye D. Sympathetic nerve activity and neurotransmitter release in humans: Translation from pathophysiology into clinical practice. Acta Physiol. Scand. 177: 275–284 (2003)CrossRefGoogle Scholar

Copyright information

© The Korean Society of Food Science and Technology and Springer Netherlands 2010

Authors and Affiliations

  • Tae-Wook Kim
    • 1
  • Young-Oh Shin
    • 1
  • Jeong-Beom Lee
    • 1
    Email author
  • Young-Ki Min
    • 1
  • Hun-Mo Yang
    • 1
  1. 1.Department of Physiology, College of MedicineSoonchunhyang UniversityCheonan, ChungnamKorea

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