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Protective effect of volatile extract from Pinus densiflora against aflatoxin B1-induced oxidative stress in HepG2 cells

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Abstract

Pinus densiflora is one of the traditional medicinal plants found in the East Asia, which has a diversity of biological activities including antioxidant effect. The protective effects of a volatile extract from Pinus densiflora (VEPN) against aflatoxin B1 (AFB1)-induced oxidative stress were investigated in human hepatoma cell line, HepG2. Treatment of HepG2 with VEPN significantly reduced the levels of intracellular reactive oxygen species, thiobarbituric acid reactive substances and 8-hydroxy-2′-deoxyguanosine elevated by AFB1, but it increased the level of reduced glutathione. These results indicate that VEPN may afford cytoprotection by attenuating AFB1-induced oxidative stress.

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Authors and Affiliations

  1. Food Safety Research Center, Korea Food Research Institute, Seongnam, Gyeonggi, 463-746, Korea

    Hyun-Joo Chang & Hyang Sook Chun

  2. Department of Food and Nutrition, Kyung Hee University, Seoul, 130-701, Korea

    Joon-Kyoung Lee

Authors
  1. Joon-Kyoung Lee
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  2. Hyun-Joo Chang
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  3. Hyang Sook Chun
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Correspondence to Hyang Sook Chun.

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Lee, JK., Chang, HJ. & Chun, H.S. Protective effect of volatile extract from Pinus densiflora against aflatoxin B1-induced oxidative stress in HepG2 cells. Food Sci Biotechnol 19, 229–233 (2010). https://doi.org/10.1007/s10068-010-0031-0

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  • DOI: https://doi.org/10.1007/s10068-010-0031-0

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