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Global trends in research of melanoma differentiation-associated gene 5: a bibliometric analysis from 2002 to 2022

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Abstract

Background

Melanoma differentiation-associated gene 5 (MDA5), as a cytoplasmic sensor for viral double-stranded RNAs, has received increasing attention in recent years. Although considerable headway has been made on the functional role of MDA5 in antiviral immunity and autoimmune disease, the available literature is insufficient to assess the vast field.

Methods

This study performed a bibliometric analysis to investigate current hotspots in the global scientific output of MDA5 over the past two decades. Related publications and recorded information from 2002 to 2022 in the Web of Science Core Collection (WoSCC) database were retrieved. VOSviewer and CiteSpace were used for quantitative evaluation and visualization.

Results

A total of 2267 original articles and reviews were obtained, and the annual number of publications related to MDA5 was increasing rapidly. China has published the most papers, while the USA was the most influential country with the most citations and the highest H-index. The Chinese Academy of Sciences, the United States Department of Health and Human Services, and the Journal of Virology were the most prolific research affiliation, funding source, and journal, respectively. Fujita T (Kyoto University) was the most productive author with the highest H-index and had close cooperation with Kato H and Yoneyama M. The keywords “RIG-I,” “MDA5,” “innate immunity,” “double-stranded-RNA,” and “recognition” had the highest frequency, while “dermatomyositis” as well as “autoantibody” seemed to be the emerging hotspots.

Conclusion

This study comprehensively demonstrated the research frontiers of MDA5 and will provide a useful resource for scholars to conduct future decisions.

Key Points

  • We conducted the first in-depth survey of the research frontiers on melanoma differentiation-associated gene 5 (MDA5) over the past two decades via bibliometric analysis.

  • We found that many early breakthroughs have been made in the mechanism of MDA5-mediated antiviral immune responses, and the role of MDA5 in autoimmune and autoinflammatory diseases has raised the recent concern.

  • We identified that the virus infection-associated pathogenesis and effective therapeutic strategy of anti-MDA5 antibody-positive dermatomyositis will remain the hotspots in the future.

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Data availability

The original contributions presented in the study are included in the article. Further inquiries can be directed to the corresponding author.

Abbreviations

MDA5:

Melanoma differentiation-associated gene 5

CARD:

Caspase recruitment domain

PRR:

Pattern-recognition receptor

RPILD:

Rapidly progressive interstitial lung disease

DM:

Dermatomyositis

RLRs:

RIG-I-like receptors

Nc:

Number of citations

Ac:

Average citation per item

Np:

Number of publications

GCS:

Global citation score

MAVS:

Mitochondrial antiviral signaling protein

TRAF:

Tumor necrosis factor receptor-associated factors

MSAs:

Myositis-specific autoantibodies

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Funding

This work was supported in part by the Chinese National Key Technology R&D Program, Ministry of Science and Technology [2022YFC2504600-6, 2021YFC2501301-6], CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-I2M-1-005], and National High Level Hospital Clinical Research Funding [2022-PUMCH-C-020, 2022-PUMCH-D-009].

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Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    Xueting Yuan, Jia Shi, Zhao Peng, Liying Peng, Shuang Zhou, Chanyuan Wu, Jiuliang Zhao, Dong Xu, Mengtao Li, Qian Wang & Xiaofeng Zeng

  2. National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing, China

    Xueting Yuan, Jia Shi, Zhao Peng, Liying Peng, Shuang Zhou, Chanyuan Wu, Jiuliang Zhao, Dong Xu, Mengtao Li, Qian Wang & Xiaofeng Zeng

  3. State Key Laboratory of Complex Severe and Rare Diseases, Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, China

    Xueting Yuan, Jia Shi, Zhao Peng, Liying Peng, Shuang Zhou, Chanyuan Wu, Jiuliang Zhao, Dong Xu, Mengtao Li, Qian Wang & Xiaofeng Zeng

  4. State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China

    Qian Wang & Xiaofeng Zeng

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Contributions

QW and XFZ contributed to the design of the study and performed the supervision. XTY did this bibliometrics analysis and wrote the initial draft of the manuscript. JS, ZP, LYP, SZ, CYW, JLZ, DX, and MTL reviewed and edited the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Qian Wang or Xiaofeng Zeng.

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Yuan, X., Shi, J., Peng, Z. et al. Global trends in research of melanoma differentiation-associated gene 5: a bibliometric analysis from 2002 to 2022. Clin Rheumatol 43, 1111–1126 (2024). https://doi.org/10.1007/s10067-023-06851-x

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