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Pre-sarcopenia is associated with health-related quality of life in patients with primary Sjögren’s syndrome

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Abstract

Objectives

Primary Sjögren’s syndrome leads to pain and fatigue that may cause impaired muscle function and muscle mass. This study aimed to determine the presence of pre-sarcopenia and to clarify associated factors with pre-sarcopenia in primary Sjögren’s syndrome patients.

Method

This cross-sectional study recruited 49 patients with primary Sjögren’s syndrome and 49 age- and gender-matched healthy controls. Sarcopenia was assessed according to European Working Group on Sarcopenia in Older People in 2018 (EGSWOP2) criteria by evaluating muscle mass, gait speed, and grip strength. Physical function was also assessed with five times sit-to-stand (FTSTS) test. Quality of life (QoL), psychological symptoms, and nutritional status were evaluated using Sarcopenia Quality of Life (SarQoL) questionnaire, Hospital Anxiety and Depression Scale (HADS), and Mini Nutritional Assessment Long Form (MNA-LF), respectively.

Results

Pre-sarcopenia was detected in 28.5% of patients with primary Sjögren’s syndrome and 6.1% of healthy controls (p = 0.006). Patients with pre-sarcopenia were older and had worse scores in terms of depression, QoL, pain scores, grip strength, and gait speed compared with those without pre-sarcopenia. The SarQoL scores and grip strength were significantly correlated with gait speed, pain, FTSTS test, and depression. Logistic regression analyses identified that the independent predictive factor for pre-sarcopenia was QoL (OR: 0.79, 95% CI: 0.65–0.95; p = 0.015).

Conclusions

Maintaining adequate muscle mass and muscle function in patients with primary Sjögren’s syndrome may contribute toward improving health-related QoL. Also, controlling depression and malnutrition risk may help to reduce the risk of development of sarcopenia.

Key Points

• Pre-sarcopenia is detected in 28.4% of the patients with primary Sjögren’s syndrome which is higher than healthy controls.

• Pre-sarcopenia is associated with health-related quality of life in primary Sjögren’s syndrome.

• Psychological symptoms and low physical performance are more common in pre-sarcopenic patients.

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Acknowledgements

We thank all the patients who participated in this study.

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Authors and Affiliations

  1. Department of Physiotherapy and Rehabilitation, Acıbadem Mehmet Ali Aydınlar University, Kayışdağı St, No: 32, Ataşehir, 34752, Istanbul, Turkey

    Özgül Öztürk & Özlem Feyzioğlu

  2. Department of Rheumatology, Haydarpaşa Numune Research and Training Hospital, University of Health Sciences, Istanbul, Turkey

    Fatih Sarıtaş

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  1. Özgül Öztürk
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  2. Özlem Feyzioğlu
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  3. Fatih Sarıtaş
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Contributions

Study conception and design were conducted by Özgül Öztürk and Özlem Feyzioğlu. Material preparation, data collection, and analysis were performed by Özgül Öztürk, Özlem Feyzioğlu, and Fatih Sarıtaş. The first draft of the manuscript was written by Özgül Öztürk and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Özgül Öztürk.

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Ethical approval was obtained from Acıbadem Mehmet Ali Aydınlar University Ethics Committee (ATADEK 2021-10/07).

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All participants gave their written informed consent before participating in the study.

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Öztürk, Ö., Feyzioğlu, Ö. & Sarıtaş, F. Pre-sarcopenia is associated with health-related quality of life in patients with primary Sjögren’s syndrome. Clin Rheumatol 42, 783–791 (2023). https://doi.org/10.1007/s10067-022-06427-1

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  • DOI: https://doi.org/10.1007/s10067-022-06427-1

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