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Different epidemiologic profiles of systemic vasculitis between Brazil and Peru—preliminary results in two referral centers from both countries

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Abstract

Little is known about the epidemiology of systemic vasculitis in South American countries. The aim of this study is to compare the prevalence of systemic vasculitides in two vasculitis referral centers from Brazil and Peru. A cross-sectional study was performed and all patients above 18 years of age, with at least 6 months of follow-up and who met classification or diagnosis criteria for the most common forms of vasculitis, were included. A total of 562 patients with systemic vasculitis were analyzed, 345 (61.4%) from Brazil and 217 (38.6%) from Peru. The frequency of Behçet’s disease (37.9% vs. 1.8%; p < 0.0001), Takayasu arteritis (TAK) (25.2% vs. 6.9%; p < 0.0001), and giant cell arteritis (9.8% vs. 0.9%; p < 0.0001) was higher in the Brazilian center than the Peruvian one. On the other hand, the frequency of microscopic polyangiitis (MPA) (67.3% vs. 2.8%; p < 0.0001) and renal-limited vasculitis (2.8% vs. 0.0%; p = 0.009) was higher in the Peruvian center. No differences were found concerning other forms of vasculitis. At diagnosis, Brazilian patients with TAK, granulomatosis with polyangiitis, and MPA were younger than Peruvian patients. Epidemiologic differences in the frequency of systemic vasculitis are observed between a vasculitis referral center from Brazil and another from Peru.

Key Points

• Significant differences are observed regarding the epidemiologic profile of systemic vasculitis between Brazil and Peru.

• MPA is the predominant form of vasculitis in Peru while BD and TAK are the most frequent forms of vasculitis in Brazil.

• The age at diagnosis of TAK, MPA, and GPA was lower in Brazilian patients than in Peruvian patients.

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Fig. 1

Data availability

The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Rheumatology Division, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, São Paulo, SP, 740, Brazil

    Alexandre W. S. de Souza, Eduarda Bonelli Zarur & Emília Inoue Sato

  2. Department of Rheumatology, Hospital Nacional Guillermo Almenara Irigoyen, EsSalud, Lima, Peru

    Victor R. Pimentel-Quiroz, Alfredo Sanchez-Torres & Manuel F. Ugarte-Gil

  3. Universidad Científica del Sur, Lima, Peru

    Victor R. Pimentel-Quiroz & Manuel F. Ugarte-Gil

Authors
  1. Alexandre W. S. de Souza
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  2. Eduarda Bonelli Zarur
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  3. Victor R. Pimentel-Quiroz
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  4. Alfredo Sanchez-Torres
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  5. Manuel F. Ugarte-Gil
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  6. Emília Inoue Sato
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Contributions

AWSS gave substantial contributions to the conception or design of the work; drafted the manuscript; and gave the final approval of the version to be published. EBZ, VRPQ, and AST worked on the acquisition, analysis, and interpretation of data for the work; revised the data critically for important intellectual content; and gave final approval of the version to be published. MUG gave substantial contributions to the conception and design of the work; he revised it critically for important intellectual content and gave final approval of the version to be published. EIS gave substantial contribution to the conception and design of the work; she revised it critically for important intellectual content and gave final approval of the version to be published. All authors (AWSS, EBZ, VRPQ, AST, MUG, and EIS) agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Alexandre W. S. de Souza.

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Ethics approval

The manuscript does not contain clinical studies or individual patient data. The study protocol was approved by the institutional review boards: CEP UNIFESP (protocol nr. 0147/2016) and Comité Institucional de Ética en Investigación Hospital Nacional Guillermo Almenara Irigoyen (protocol nr. 21–2020).

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de Souza, A.W.S., Zarur, E.B., Pimentel-Quiroz, V.R. et al. Different epidemiologic profiles of systemic vasculitis between Brazil and Peru—preliminary results in two referral centers from both countries. Clin Rheumatol 41, 635–639 (2022). https://doi.org/10.1007/s10067-021-06032-8

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  • DOI: https://doi.org/10.1007/s10067-021-06032-8

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