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Clinical characteristics and radiographic outcomes of vascular Behçet’s disease involving the aorta or its major branches

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Abstract

Objective

To describe the clinical characteristics and radiographic outcomes of vascular Behçet’s disease (BD) involving the aorta or its major branches.

Methods

This retrospective cohort study was performed in patients with vascular BD involving the aorta or its major branches. All included patients underwent computed tomography angiography (CTA) at least two times with a 2- to 5-year interval. Radiographic progression was defined as newly developed and/or aggravated (> 20%) characteristic features on CTA.

Results

The cohort included 22 patients with BD with a median interval of 3.65 years between the initial and follow-up CTA. Five patients (22.7%) showed radiographic progression. Patients with radiographic progression had a longer disease duration at baseline than those without (6.67 vs. 0.26 years, p = 0.028). Of all patients, 21 (95.5%) had vascular aneurysms/pseudoaneurysms and 11 (50.0%) had thrombosis. The most frequently involved artery with aneurysmal change was the abdominal aorta (8/21, 38.1%), followed by the iliac arteries (5/21, 23.8%). In the case of thrombosis, the most frequently involved arteries were the femoral (4/11, 36.4%) and iliac (4/11, 36.4%) arteries. The characteristics and locations of vascular involvement did not significantly differ according to the radiographic outcome.

Conclusions

A considerable proportion of patients with BD with arterial involvement showed radiographic progression within 2–5 years. Patients with radiographic progression had a longer disease duration at baseline. The most common form of arterial involvement of BD was aneurysmal change, followed by thrombus formation.

Key Points:

• This study evaluated for the first time the radiographic outcomes of 22 patients with Behçet’s disease involving the aorta or its major branches.

• A considerable proportion of patients (5/22, 22.7%) showed radiographic progression.

• Patients with radiographic progression had a longer disease duration at baseline than their counterparts; however, no other clinical factors were significantly different.

• The most frequent form of vascular involvement was pseudoaneurysm followed by thrombosis.

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Data availability

All data generated or analyzed during this study are included in this published article.

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Authors and Affiliations

  1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea

    Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh, Duk-Kyung Kim & Hoon-Suk Cha

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  1. Seulkee Lee
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Seulkee Lee. The first draft of the manuscript was written by Seulkee Lee and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Hoon-Suk Cha.

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Lee, S., Kang, S., Eun, Y. et al. Clinical characteristics and radiographic outcomes of vascular Behçet’s disease involving the aorta or its major branches. Clin Rheumatol 41, 1769–1777 (2022). https://doi.org/10.1007/s10067-021-06031-9

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  • DOI: https://doi.org/10.1007/s10067-021-06031-9

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