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The associations of phase angle with the structural severity and quadriceps strength among patients with hip osteoarthritis: the SPSS-OK study

Clinical Rheumatology volume 40, pages 1539–1546 (2021)Cite this article

Abstract

Introduction/objectives

This study examined whether phase angle (PhA) is associated with hip osteoarthritis (HOA) severity and quadriceps strength in patients with HOA.

Method

A series of 549 patients with HOA, obtained from the Screening for People Suffering Sarcopenia in the Orthopedic cohort of Kobe study, were analyzed. PhA and quadriceps strength were measured using bioelectrical impedance analysis and a handheld dynamometer, respectively. The HOA severity was graded using the Kellgren-Lawrence radiographic scale. We estimated (1) mean differences in PhA by differences in HOA severity and (2) mean differences in quadriceps strength by differences in PhA using general linear models.

Results

The patients’ mean age was 64.9 years, and 85% were women. A decreasing trend of PhA associated with increasing HOA severity was observed (P for trend < 0.001). PhA was statistically associated with a decrease in HOA grade 4 compared with that associated with HOA grade 1 (mean difference, − 0.40°; 95% confidence interval (CI), − 0.51° to − 0.30°). PhA per leg was associated with greater quadriceps strength per leg independent of age, sex, leg muscle mass, and HOA severity (mean difference per 1° increase, 3.80 Nm; 95% CI, 0.93 to 6.66). There was insufficient evidence of any difference in the association between PhA and quadriceps strength by HOA severity and sex (P for interaction = 0.07 and 0.06, respectively).

Conclusions

PhA gradually decreased with increasing HOA severity, especially in patients with end-stage HOA. Paying close attention to PhA might provide a key to increasing quadriceps strength, regardless of HOA severity.

Key Points

• PhA gradually decreased with progression of HOA, particularly in patients with end-stage HOA.

• PhA was positively associated with quadriceps strength, regardless of HOA severity.

• PhA could be one of the indicators of quadriceps strength in patients with HOA.

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Availability of data and material

The datasets generated during and/or analyzed during the present study are available from the corresponding author on reasonable request.

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Funding

This study was supported by JSPS KAKENHI (Grant Number: JP15K16518). The JSPS had no role in this study except for funding.

Author information

Authors and Affiliations

  1. Anshin Hospital, Kobe, Japan

    Osamu Wada & Kiyonori Mizuno

  2. Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tokyo, Japan

    Minoru Yamada

  3. Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan

    Tsukasa Kamitani

  4. Department of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan

    Noriaki Kurita

  5. Department of Innovative Research and Education for Clinicians and Trainees (DiRECT), Fukushima Medical University Hospital, Fukushima, Japan

    Noriaki Kurita

  6. Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University, Fukushima, Japan

    Noriaki Kurita

Authors
  1. Osamu Wada
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  2. Minoru Yamada
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  3. Tsukasa Kamitani
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  4. Kiyonori Mizuno
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  5. Noriaki Kurita
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Contributions

Research idea and study design: OW and NK; data acquisition: OW and KM; data analysis and interpretation: OW, NK, MY, TK, and KM; statistical analysis: NK; supervision or mentorship: NK, MY, TK, and KM. Each author contributed important intellectual content during article drafting or revision and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or integrity of any portion of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Noriaki Kurita.

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Disclosures

None.

Ethics approval

The study was approved by the local institutional review board (No. 57, 26 January 2017) and by the Research Ethics Committee of Fukushima Medical University School of Medicine (No. 2850, 28 September 2016).

Consent to participate

Obtaining patients’ informed consent for the present study was not mandatory according to the “Ethical Guidelines for Medical and Health Research Involving Human subjects” in Japan. However, all patients provided written informed consent prior to participation.

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Not applicable

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Wada, O., Yamada, M., Kamitani, T. et al. The associations of phase angle with the structural severity and quadriceps strength among patients with hip osteoarthritis: the SPSS-OK study. Clin Rheumatol 40, 1539–1546 (2021). https://doi.org/10.1007/s10067-020-05419-3

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  • DOI: https://doi.org/10.1007/s10067-020-05419-3

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