References
Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR (2015) Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. Osteoarthr Cartil 23:1158–1164. https://doi.org/10.1016/j.joca.2015.02.016
Gómez-Aristizábal A, Gandhi R, Mahomed NN, Marshall KW, Viswanathan S (2019) Synovial fluid monocyte/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: a cohort study. Arthritis Res Ther 21:26. https://doi.org/10.1186/s13075-018-1798-2
Larsson S, Englund M, Struglics A, Lohmander LS (2012) The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study. Osteoarthr Cartil 20:388–395. https://doi.org/10.1016/j.joca.2012.02.001
Larsson S, Englund M, Struglics A, Lohmander LS (2015) Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy. Osteoarthr Cartil 23:1906–1914. https://doi.org/10.1016/j.joca.2015.05.035
De Santis M, Di Matteo B, Chisari E, Cincinelli G, Angele P, Lattermann C et al (2018) The role of Wnt pathway in the pathogenesis of OA and its potential therapeutic implications in the field of regenerative medicine. Biomed Res Int 2018:1–8. https://doi.org/10.1155/2018/7402947
Theologis T, Efstathopoulos N, Nikolaou V, Charikopoulos I, Papapavlos I, Kokkoris P, Papatheodorou A, Nasiri-Ansari N, Kassi E (2017) Association between serum and synovial fluid Dickkopf-1 levels with radiographic severity in primary knee osteoarthritis patients. Clin Rheumatol 36:1865–1872. https://doi.org/10.1007/s10067-017-3640-7
Finan PH, Buenaver LF, Bounds SC, Hussain S, Park RJ, Haque UJ, Campbell CM, Haythornthwaite JA, Edwards RR, Smith MT (2013) Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization. Arthritis Rheum 65:363–372. https://doi.org/10.1002/art.34646
Weng LH, Wang CJ, Ko JY, Sun YC, Wang FS (2010) Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Arthritis Rheum 62:1393–1402. https://doi.org/10.1002/art.27357
Yazici Y, McAlindon TE, Fleischmann R, Gibofsky A, Lane NE, Kivitz AJ et al (2017) A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study. Osteoarthr Cartil 25:1598–1606. https://doi.org/10.1016/j.joca.2017.07.006
Miyamoto K, Ohkawara B, Ito M, Masuda A, Hirakawa A, Sakai T, Hiraiwa H, Hamada T, Ishiguro N, Ohno K (2017) Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling. PLoS One 12:e0184388. https://doi.org/10.1371/journal.pone.0184388
Funding
Thomas Theologis was supported by the A.G. Leventis Foundation (2016–2018). Funding sources had no role in the design, collection, and interpretation of data, writing of the manuscript, or in the decision to submit for publication.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
This study was approved by the ethics committees of Konstantopouleio–‘Agia Olga’ Hospital and Thriassio Hospital and was conducted in agreement with the Declaration of Helsinki. All participants (patients and healthy volunteers) gave their informed consent.
Disclosures
None.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Vasileios S. Nikolaou and Eva Kassi are equally last authorship
Rights and permissions
About this article
Cite this article
Theologis, T.P., Masouros, P.T., Benakis, L. et al. Investigating correlation between self-reported clinical manifestation and synovial fluid and blood levels of Dickkopf-1 and sclerostin in patients with primary knee osteoarthritis. Clin Rheumatol 39, 3889–3891 (2020). https://doi.org/10.1007/s10067-020-05303-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-020-05303-0