Skip to main content

Advertisement

SpringerLink
Log in

Coexistence of antiphospholipid syndrome and cryoglobulinemia in a patient with rheumatoid arthritis

  • Letter to the Editor
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

We present here a case of severe digital necrosis in a patient with long-standing rheumatoid arthritis (RA). The concomitant presence of two autoimmune conditions such as cryoglobulinemia and antiphospholipid syndrome (APS) were diagnosed. To best of our knowledge, this is the first case of the coexistence of RA, cryoglobulinemia, and APS in a single patient. An aggressive treatment was needed including hallux amputation, methylprednisolone pulses followed by rituximab with favorable outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Cacoub P, Comarmond C, Domont F (2015) Cryoglobulinemia Vasculitis. Am J Med 128:950–955

    Article  Google Scholar 

  2. Gómez-Puerta JA, Cervera R (2014) Diagnosis and classification of the antiphospholipid syndrome. J Autoimmun 48-49:20–25

    Article  Google Scholar 

  3. Shachaf S, Yair M (2016) The correlation between antiphospholipid syndrome and cryoglobulinemia: case series of 4 patients and review of the literature. Rev Bras Reumatol Engl Ed 56:2–7

    Article  Google Scholar 

  4. Hanly JG, Smith SA (2000) Autoinmune antiphospholipid antibodies and cryoglobulinemia. Lupus 9:264–270

    Article  CAS  Google Scholar 

  5. Andrejevic S, Bonaci-Nikolic B, Bukilica M, Milivojevic G, Basanovic J, Nikolic MM (2003) Purpura and leg ulcers in a patient with cryoglobulinaemia, non-Hodgkin’s lymphoma, and antiphospholipid syndrome. Clin Exp Dermatol 28:151–153

    Article  CAS  Google Scholar 

  6. Kaegi C, Wuest B, Schreiner J, Steiner UC, Vultaggio A, Matucci A, Crowley C, Boyman O (2019) Systematic review of safety and efficacy of rituximab in treating immune-mediated disorders. Front Immunol 10:1990

    Article  CAS  Google Scholar 

  7. Erkan D, Vega J, Ramon G, Kozora E, Lockshin MD (2013) A pilot open-label phase II trial of rituximab for non-criteria manifestations of antiphospholipid syndrome. Arthritis Rheum 65:464–471

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rheumatology Department, Hospital Clinic of Barcelona, Villarroel 170, 08036, Barcelona, Spain

    Katherine Cajiao & José A. Gómez-Puerta

Authors
  1. Katherine Cajiao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. José A. Gómez-Puerta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to José A. Gómez-Puerta.

Ethics declarations

Conflict of interest

The authors declare no conflict of interest.

Disclosure statement

Written informed consent for publication of their clinical details and clinical images was obtained from the patient.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cajiao, K., Gómez-Puerta, J.A. Coexistence of antiphospholipid syndrome and cryoglobulinemia in a patient with rheumatoid arthritis. Clin Rheumatol 39, 2833–2835 (2020). https://doi.org/10.1007/s10067-020-05127-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-020-05127-y

Keywords

Search

Navigation