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Neck circumference is an independent risk factor for hyperuricemia within 3 years in women: a longitudinal study

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Abstract

Introduction

Our previous cross-sectional study revealed the association between neck circumference (NC) and hyperuricemia. This study aimed to further investigate the longitudinal association between NC and hyperuricemia and to compare the strengths of longitudinal association of NC and waist circumference (WC) with hyperuricemia.

Methods

A total of 4383 subjects without hyperuricemia at baseline were included. Multivariable linear regression was used to assess the association between baseline anthropometric indices and uric acid level at follow-up. Cox regression was used to assess the relationship between baseline anthropometric indices and the risk of future hyperuricemia. A receiver-operating characteristic curve was used to compare the predictive ability of baseline anthropometric indices for future hyperuricemia.

Results

Among women, only baseline NC was positively, linearly associated with uric acid level at follow-up (β = 1.75) and risk of future hyperuricemia (ptrend < 0.05); risk of hyperuricemia in the third and fourth quartile groups of baseline NC significantly increased, compared with the first quartile group of baseline NC (HR = 1.48 and 1.81, respectively). Among men, neither NC nor WC was associated with hyperuricemia after adjusting for confounder factors. The area under the curve of baseline NC and WC for hyperuricemia was comparable in both genders (0.606 for NC and 0.599 for WC in women, 0.578 for NC and 0.602 for WC in men).

Conclusions

For women, only baseline NC is an independent risk factor of hyperuricemia within 3 years. NC and WC have a similar 3-year predictive ability for hyperuricemia in both genders.

Key Points

• This is the first study to assess the longitudinal association between neck circumference and hyperuricemia.

• According to the results of this study, we propose for the first time that neck circumference is an independent risk factor for hyperuricemia in women in the future, rather than waist circumference.

• We found for the first time that neck circumference and waist circumference have similar predictive ability for future hyperuricemia in both genders.

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Acknowledgments

We appreciated the efforts of all participants who contributed to sample measurements and data collections.

Funding

This study was funded by the National Natural Science Foundation of China (31672375) and the National Key Research and Development Program of China (2018YFC1314100).

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Author notes

  1. Ping An and Kang Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Endocrinology, Chinese PLA General Hospital, Beijing, China

    Ping An, Kang Chen, Anping Wang, Xinye Jin, Yulong Chen, Weijun Gu, Wenhua Yan, Li Zang, Jingtao Dou, Yiming Mu & Zhaohui Lv

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  1. Ping An
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Correspondence to Yiming Mu or Zhaohui Lv.

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All participants provided informed consent. The present study was performed according to the Declaration of Helsinki, and the protocol of this study was approved by the Committee on Human Research of the Chinese People’s Liberation Army General Hospital.

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An, P., Chen, K., Wang, A. et al. Neck circumference is an independent risk factor for hyperuricemia within 3 years in women: a longitudinal study. Clin Rheumatol 39, 3757–3767 (2020). https://doi.org/10.1007/s10067-020-05095-3

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