Real-world experience of secukinumab treatment for ankylosing spondylitis at the Royal National Hospital for Rheumatic Diseases, Bath

Abstract

We reviewed our experience of treating ankylosing spondylitis patients with the IL-17 inhibitor secukinumab at the Royal National Hospital for Rheumatic Diseases, Bath. A total of 76 patients were included, of whom secukinumab was the first-line biologic drug used in 24, second line in 23, and third line in 29 patients, respectively. Only 5 patients discontinued the drug due to side effects before their first outpatient review, including 1 new case of inflammatory bowel disease. Significant improvements were seen in all disease outcome measures in patients receiving secukinumab as their first-line biologic agent, with a trend to improved mean BASDAI and BASFI even in patients receiving it as a second- or third-line biologic agent. This real-world analysis adds to the evidence recommending secukinumab as a largely safe and effective treatment for ankylosing spondylitis.

Key Points
Secukinumab was efficacious for improving short-term mean disease activity and function in our cohort of ankylosing spondylitis patients, regardless of whether used as the first-, second-, or third-line biologic disease-modifying drug.
There were very low rates of discontinuation due to side effects in our cohort of secukinumab-treated ankylosing spondylitis patients.

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Acknowledgments

Dr. Raj Sengupta would like to acknowledge his grants from Abbvie, Biogen, Novartis, Celgene, and UCB.

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Correspondence to Thomas Williams.

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All data reported in this article was obtained from routine clinical practice. Patients included have all provided informed consent to enter the BathSpA biobank database for the purpose of research studies.

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Williams, T., Wadeley, A., Bond, D. et al. Real-world experience of secukinumab treatment for ankylosing spondylitis at the Royal National Hospital for Rheumatic Diseases, Bath. Clin Rheumatol 39, 1501–1504 (2020). https://doi.org/10.1007/s10067-020-04944-5

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Keywords

  • Ankylosing spondylitis
  • Biologic disease-modifying drug
  • Secukinumab