Abstract
Objective
This study explored the role of central sensitization (CS) pain in patients with various rheumatic diseases using the CS inventory (CSI).
Methods
A total of 193 patients of mean age 50.72 ± 9.65 years were included; they were divided into four different groups in terms of their rheumatic diseases. Patients with rheumatoid arthritis (RA), spondyloarthropathy (SpA), osteoarthritis (OA), and fibromyalgia syndrome (FMS) were evaluated in tertiary care rheumatology/pain medicine settings. Disease duration and activity, the Bath Ankylosing Spondylitis Disease Activity Index, the Disease Activity Score-28, and pain severity (evaluated using a visual analog scale) were assessed, and the Turkish version of the CSI administered.
Results
CS syndromes were present in almost half the patients (45% of SpA, 41% of RA, 62% of OA, and 94% of FMS patients). We found no significant relationship between disease activity and the CSI-A scores in SpA or RA patients (p = 0.731 and p = 0.390, respectively). As expected, the CSI-A scores were highest in the FMS group (p = 0.000), but were similar in the other groups (p < 0.05). CS-related syndromes (CSI-B conditions) were present at similar frequencies in the RA, SpA, and OA groups, but were less common in the FMS group (p = 0.000).
Conclusions
The CSI usefully detects CS pain in patients with rheumatic diseases. Treatment of such pain can enhance the quality of daily life in patients with rheumatic diseases.
Key Point • Central sensitization pain is common in patients with rheumatic diseases including rheumatoid arthritis, spondyloarthropathies, and osteoarthritis. |
Similar content being viewed by others
References
Bas DB, Su J, Wigerblad G, Svensson CI (2016) Pain in rheumatoid arthritis: models and mechanisms. Pain Manag 6(3):265–284
Walitt B, Nahin RL, Katz RS, Bergman MJ, Wolfe F (2015) The prevalence and characteristics of fibromyalgia in the 2012 National Health Interview Survey. PLoS One 10(9):e0138024
Atzeni F, Boccassini L, Di Franco M, Alciati A, Marsico A, Cazzola M, Cassisi G, Sarzi-Puttini P (2014) Chronic widespread pain in spondyloarthritis. Reumatismo 66(1):28–32
Boyden SD, Hossain IN, Wohlfahrt A, Lee YC (2016) Non-inflammatory causes of pain in patients with rheumatoid arthritis. Curr Rheumatol Rep 18(6):30
Srirangan S, Choy EH (2010) The role of interleukin 6 in the pathophysiology of rheumatoid arthritis. Ther Adv Musculoskelet Dis 2(5):247–256
Walsh DA, McWilliams DF (2014) Mechanisms, impact and management of pain in rheumatoid arthritis. Nat Rev Rheumatol 10(10):581–592
Havelin J, Imbert I, Cormier J, Allen J, Porreca F, King T (2016) Central sensitization and neuropathic features of ongoing pain in a rat model of advanced osteoarthritis. J Pain 17(3):374–382
Finan PH, Buenaver LF, Bounds SC, Hussain S, Park RJ, Haque UJ, Campbell CM, Haythornthwaite JA, Edwards RR, Smith MT (2013) Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization. Arthritis Rheum 65(2):363–372
Bidad K, Gracey E, Hemington KS, Mapplebeck JC, Davis KD, Inman RD (2017) Pain in ankylosing spondylitis: a neuro-immune collaboration. Nat Rev Rheumatol 13(7):410–420
Sarzi-Puttini P, Salaffi F, Di Franco M, Bazzichi L, Cassisi G, Casale R, Cazzola M, Stisi S, Battellino M, Atzeni F (2014) Pain in rheumatoid arthritis: a critical review. Reumatismo 66(1):18–27
Perrot S (2015) Osteoarthritis pain. Best Pract Res Clin Rheumatol 29(1):90–97
Woolf CJ (2011) Central sensitization: implications for the diagnosis and treatment of pain. Pain 152(3):S2–S15
Lluch Girbés E, Nijs J, Torres-Cueco R, López Cubas C (2013) Pain treatment for patients with osteoarthritis and central sensitization. Phys Ther 93(6):842–851
Neblett R, Cohen H, Choi Y, Hartzell MM, Williams M, Mayer TG, Gatchel RJ (2013) The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample. J Pain 14(5):438–445
Coronado RA, George SZ (2018) The Central Sensitization Inventory and Pain Sensitivity Questionnaire: an exploration of construct validity and associations with widespread pain sensitivity among individuals with shoulder pain. Musculoskelet Sci Pract 36:61–67
Scerbo T, Colasurdo J, Dunn S, Unger J, Nijs J, Cook C (2018) Measurement properties of the central sensitization inventory: a systematic review. Pain Pract 18(4):544–554
Mayer TG, Neblett R, Cohen H, Howard KJ, Choi YH, Williams MJ, Perez Y, Gatchel RJ (2012) The development and psychometric validation of the central sensitization inventory. Pain Pract 12(4):276–285
Kindler LL, Bennett RM, Jones KD (2011) Central sensitivity syndromes: mounting pathophysiologic evidence to link fibromyalgia with other common chronic pain disorders. Pain Manag Nurs 12(1):15–24
Smart KM, Blake C, Staines A, Doody C (2011) The discriminative validity of “nociceptive,”“peripheral neuropathic,” and “central sensitization” as mechanisms-based classifications of musculoskeletal pain. Clin J Pain 27(8):655–663
Düzce E, Birtane M (2017) PM&R Specialty Thesis, Department of PM&R. Trakya University Medical School. Unpublished manuscript
Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21(12):2286–2291
Prevoo M, Van'T Hof MA, Kuper H, Van Leeuwen M, Van De Putte L, Van Riel P (1995) Modified disease activity scores that include twenty-eight-joint counts development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 38(1):44–48
French HP, Smart KM, Doyle F (2017) Prevalence of neuropathic pain in knee or hip osteoarthritis: a systematic review and meta-analysis. Semin Arthritis Rheum 47(1):1–8
McWilliams DF, Walsh DA (2017) Pain mechanisms in rheumatoid arthritis. Clin Exp Rheumatol 35(5):94–101
Salaffi F, Di MC, Carotti M, Sarzi-Puttini P (2019) The effect of neuropathic pain symptoms on remission in patients with early rheumatoid arthritis. Curr Rheumatol Rev 15(2):154–161
Meeus M, Vervisch S, De Clerck LS, Moorkens G, Hans G, Nijs J (2012) Central sensitization in patients with rheumatoid arthritis: a systematic literature review. Semin Arthritis Rheum 41(4):556–567
Hochman JR, French MR, Bermingham SL, Hawker GA (2010) The nerve of osteoarthritis pain. Arthritis Care Res 62(7):1019–1023
Hochman J, Gagliese L, Davis A, Hawker G (2011) Neuropathic pain symptoms in a community knee OA cohort. Osteoarthr Cartil 19(6):647–654
Choi JH, Lee SH, Kim HR, Lee KA (2018) Association of neuropathic-like pain characteristics with clinical and radiographic features in patients with ankylosing spondylitis. Clin Rheumatol 37(11):3077–3086
Gok K, Cengiz G, Erol K, Ozgocmen S (2018) Neuropathic pain component in axial spondyloarthritis and the influence on disease burden. J Clin Rheumatol 24(6):324–327
Arendt-Nielsen L (2015) Central sensitization in humans: assessment and pharmacology. Handb Exp Pharmacol 227:79–102
Sanzarello I, Merlini L, Rosa MA, Perrone M, Frugiuele J, Borghi R, Faldini C (2016) Central sensitization in chronic low back pain: a narrative review. J Back Musculoskelet Rehabil 29(4):625–633
Borstad J, Woeste C (2015) The role of sensitization in musculoskeletal shoulder pain. Braz J Phys Ther 19(4):251–257
Taylor-Gjevre RM, Gjevre JA, Nair BV (2014) Increased nocturnal periodic limb movements in rheumatoid arthritis patients meeting questionnaire diagnostic criteria for restless legs syndrome. BMC Musculoskelet Disord 15(1):378
Kurtoglu C, Kurkcu M, Sertdemir Y, Ozbek S, Gürbüz C (2016) Temporomandibular disorders in patients with rheumatoid arthritis: a clinical study. Niger J Clin Pract 19(6):715–720
Wang Y-C, Huang Y-P, Wang M-T, Wang H-I, Pan S-L (2017) Increased risk of rheumatoid arthritis in patients with migraine: a population-based, propensity score-matched cohort study. Rheumatol Int 37(2):273–279
Le H, Tfelt-Hansen P, Russell MB, Skytthe A, Kyvik KO, Olesen J (2011) Co-morbidity of migraine with somatic disease in a large population-based study. Cephalalgia 31(1):43–64
Sanchis MN, Lluch E, Nijs J, Struyf F, Kangasperko M (2015) The role of central sensitization in shoulder pain: a systematic literature review. Semin Arthritis Rheum 44(6):710–716
Batheja S, Nields JA, Landa A, Fallon BA (2013) Post-treatment lyme syndrome and central sensitization. J Neuropsychiatr Clin Neurosci 25(3):176–186
Nijs J, Malfliet A, Ickmans K, Baert I, Meeus M (2014) Treatment of central sensitization in patients with ‘unexplained’ chronic pain: an update. Expert Opin Pharmacother 15(12):1671–1683
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The study was approved by the Ankara Training and Research Hospital Ethics Committee and followed all relevant dictates of the Helsinki Declaration as revised in 2008.
Disclosures
None.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Guler, M.A., Celik, O.F. & Ayhan, F.F. The important role of central sensitization in chronic musculoskeletal pain seen in different rheumatic diseases. Clin Rheumatol 39, 269–274 (2020). https://doi.org/10.1007/s10067-019-04749-1
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-019-04749-1