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Neck circumference is associated with hyperuricemia: a cross-sectional study

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Abstract

Background/objective

Neck circumference (NC) is associated with metabolic abnormalities, independent of other obesity indices. However, data are limited regarding the potential relation between NC and serum uric acid (UA) concentrations. Therefore, we evaluated the cross-sectional association between NC and UA concentration, and odds of having hyperuricemia in a community-based cohort.

Subjects and methods

The current study included 87,782 participants (16,317 women and 71,465 men, 52.2 ± 14.1 y) of the Kailuan Study. NC and UA concentration were measured in 2014. We used generalized linear model to investigate the association between NC and serum UA concentration and logistic regression model to investigate the association between NC and likelihood of having hyperuricemia (≥ 7 mg/dl in men and ≥ 6 mg/dl in women), adjusting for demographic factor, anthropometric indices, plasma lipid profiles, blood glucose, blood pressure, physical exercise, snoring, smoking, diet quality, and alcohol consumption.

Results

Higher NC was associated with higher serum UA concentration, and higher odds of hyperuricemia in both men and women after adjusting for potential confounders (both p < 0.001). Each additional 5-cm increase in NC was associated with 6% higher likelihood of having hyperuricemia (adjusted OR = 1.06; 95% CI 1.02, 1.1) in men and 17% in women (adjusted OR = 1.17; 95% CI 1.06, 1.28) (p interaction = 0.01). Similar pattern was observed after excluding participants who reported use of anti-hypertensive drugs, participants with obesity or higher waist circumference, and participants with history of gout and chronic kidney diseases.

Conclusions

Higher NC was associated with higher serum UA concentration and higher risk of hyperuricemia in Chinese adult population.

Clinical trial number

Kailuan Study (ChiCTR-TNRC-11001489)

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Funding

The study was supported by National Natural Science Foundation of China (No. 81773407); Natural Science Foundation of Shanghai (No. 17ZR1415700).

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Authors and Affiliations

  1. Department of Clinical Nutrition, Shanghai Xin Hua Hospital, Shanghai, China

    Xiuhua Shen

  2. Department of Nutrition, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Xiuhua Shen

  3. Department of Cardiology, Kailuan General Hospital, No. 57 Xinhua Road (East), Tangshan, 063000, China

    Shouling Wu & Yuntao Wu

  4. Department of Clinical Nutrition, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Renying Xu

  5. Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China

    Renying Xu

  6. Department of Nephrology, Kailuan General Hospital, Tangshan, China

    Junjuan Li

  7. Department of Rheumatology, Kailuan General Hospital, Tangshan, China

    Liufu Cui & Rong Shu

  8. Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, 16802, USA

    Xiang Gao

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  1. Xiuhua Shen
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Correspondence to Shouling Wu or Xiang Gao.

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The study was approved by the Ethics Committee of the Kailuan General Hospital (No. ChiCTR-TNRC-11001489).

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Shen, X., Wu, S., Xu, R. et al. Neck circumference is associated with hyperuricemia: a cross-sectional study. Clin Rheumatol 38, 2373–2381 (2019). https://doi.org/10.1007/s10067-019-04541-1

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