Skip to main content

Advertisement

SpringerLink
Log in

The current role of capillaroscopy in vasculitides

  • Review Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

Nailfold capillaroscopy (NFC) has gained remarkable interest among rheumatologists because of its utility in both clinical practice and research activity. Nevertheless, there has been scarce attention on its potential in other rheumatic disorders such as vasculitis. We perform a systematic review of literature on NFC in noninfectious vasculitides, with the aim to provide an overview of the main NFC changes described, to discuss the current evidence supporting its clinical impact and applications in daily practice and to provide future research fields.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hoffman GS, Calabrese LH (2014) Vasculitis: determinants of disease patterns. Nat Rev Rheumatol 10:454–462. https://doi.org/10.1038/nrrheum.2014.89

    Article  PubMed  Google Scholar 

  2. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, Flores-Suarez LF, Gross WL, Guillevin L, Hagen EC, Hoffman GS, Jayne DR, Kallenberg CGM, Lamprecht P, Langford CA, Luqmani RA, Mahr AD, Matteson EL, Merkel PA, Ozen S, Pusey CD, Rasmussen N, Rees AJ, Scott DGI, Specks U, Stone JH, Takahashi K, Watts RA (2013) 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. Arthritis Rheum 65:1–11. https://doi.org/10.1002/art.37715

    Article  CAS  PubMed  Google Scholar 

  3. Cutolo M, Sulli A, Smith V (2013) How to perform and interpret capillaroscopy. Best Pract Res Clin Rheumatol 27:237–248. https://doi.org/10.1016/j.berh.2013.03.001

    Article  PubMed  Google Scholar 

  4. Cutolo M, Sulli A, Pizzorni C, Smith V (2010) Capillaroscopy as an outcome measure for clinical trials on the peripheral vasculopathy in SSc-is it useful? Int J Rheumatol 2010:1–6. https://doi.org/10.1155/2010/784947

    Article  Google Scholar 

  5. Tavakol ME, Fatemi A, Karbalaie A, Emrani Z, Erlandsson BE (2015) Nailfold capillaroscopy in rheumatic diseases: which parameters should be evaluated? Biomed Res Int 2015:974530–974517. https://doi.org/10.1155/2015/974530

    Article  CAS  Google Scholar 

  6. Chora I, Guiducci S, Manetti M, Romano E, Mazzotta C, Bellando-Randone S, Ibba-Manneschi L, Matucci-Cerinic M, Soares R (2015) Vascular biomarkers and correlation with peripheral vasculopathy in systemic sclerosis. Autoimmun Rev 14:314–322. https://doi.org/10.1016/j.autrev.2014.12.001

    Article  CAS  PubMed  Google Scholar 

  7. Smith V, Thevissen K, Trombetta AC, Pizzorni C, Ruaro B, EULAR Study Group on Microcirculation in Rheumatic Diseases (2016) Nailfold capillaroscopy and clinical applications in systemic sclerosis. Microcirculation 23:364–372. https://doi.org/10.1111/micc.12281

    Article  PubMed  Google Scholar 

  8. Bertolazzi C, Cutolo M, Smith V, Gutierrez M (2017) State of the art on nailfold capillaroscopy in dermatomyositis and polymyositis. Semin Arthritis Rheum 47:432–444. https://doi.org/10.1016/j.semarthrit.2017.06.001

    Article  PubMed  Google Scholar 

  9. Hughes M, Herrick AL (2016) Raynaud’s phenomenon. Best Pract Res Clin Rheumatol 30:112–132. https://doi.org/10.1016/j.berh.2016.04.001

    Article  PubMed  Google Scholar 

  10. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8:336–341. https://doi.org/10.1136/bmj.b2535

    Article  PubMed  Google Scholar 

  11. Greenberg LW (1983) Nailfold capillary abnormalities in Henoch-Schönlein purpura. J Pediatr 103:665–666

    Article  CAS  PubMed  Google Scholar 

  12. Kuryliszyn-Moskal A, Bernacka K, Klimiuk PA (1996) Circulating intercellular adhesion molecule 1 in rheumatoid arthritis-relationship to systemic vasculitis and microvascular injury in nailfold capillary microscopy. Clin Rheumatol 15:367–373

    Article  CAS  PubMed  Google Scholar 

  13. Vaiopoulos G, Pangratis N, Samarkos M, Hatzinicolaou P, Mavropoulos S, Tzonou A, Kaklamanis P (1995) Nailfold capillary abnormalities in Behçet’s disease. J Rheumatol 22:1108–1111

    CAS  PubMed  Google Scholar 

  14. Kuryliszyn-Moskal A (1998) Cytokines and soluble CD4 and CD8 molecules in rheumatoid arthritis: relationship to systematic vasculitis and microvascular capillaroscopic abnormalities. Clin Rheumatol 17:489–495

    Article  CAS  PubMed  Google Scholar 

  15. Rossi D, Mansouri M, Baldovino S, Gennaro M, Naretto C, Alpa M, Giachino O, Sena LM, Roccatello D (2004) Nail fold videocapillaroscopy in mixed cryoglobulinaemia. Nephrol Dial Transplant 19:2245–2249. https://doi.org/10.1093/ndt/gfh347

    Article  PubMed  Google Scholar 

  16. Anders HJ, Haedecke C, Sigl T, Krüger K (2000) Avascular areas on nailfold capillary microscopy of patients with Wegener’s granulomatosis. Clin Rheumatol 19:86–88

    Article  CAS  PubMed  Google Scholar 

  17. Martino F, Agolini D, Tsalikova E, Bederti O, Principessa L, Martino E, Carnevali E, Giardini O (2002) Nailfold capillaroscopy in Henoch-Schönlein purpura: a follow-up study of 31 cases. J Pediatr 141:145. https://doi.org/10.1067/mpd.2002.124308

    Article  PubMed  Google Scholar 

  18. Witkowska AM, Kuryliszyn-Moskal A, Borawska MH, Hukałowicz K, Markiewicz R (2003) A study on soluble intercellular adhesion molecule-1 and selenium in patients with rheumatoid arthritis complicated by vasculitis. Clin Rheumatol 22:414–419

    Article  PubMed  Google Scholar 

  19. Movasat A, Shahram F, Carreira PE, Nadji A, Akhlaghi M, Naderi N, Davatchi F (2009) Nailfold capillaroscopy in Behçet’s disease, analysis of 128 patients. Clin Rheumatol 28:603–605. https://doi.org/10.1007/s10067-009-1106-2

    Article  PubMed  Google Scholar 

  20. Zampetti A, Rigante D, Bersani G, Rendeli C, Feliciani C, Stabile A (2009) Longitudinal study of microvascular involvement by nailfold capillaroscopy in children with Henoch-Schönlein purpura. Clin Rheumatol 28:1101–1105. https://doi.org/10.1007/s10067-009-1200-5

    Article  PubMed  Google Scholar 

  21. Huang MY, Huang JJ, Huang TY, Gupta-Malhotra M, Syu FK (2012) Deterioration of cutaneous microcirculatory status of Kawasaki disease. Clin Rheumatol 31:847–852. https://doi.org/10.1007/s10067-012-1948-x

    Article  PubMed  PubMed Central  Google Scholar 

  22. Aytekin S, Yuksel EP, Aydin F, Senturk N, Ozden MG, Canturk T, Turanli AY (2014) Nailfold capillaroscopy in Behçet disease, performed using videodermoscopy. Clin Exp Dermatol 39:443–447. https://doi.org/10.1111/ced.12343

    Article  CAS  PubMed  Google Scholar 

  23. Alan S, Balkarlı A, Tuna S, Ozkan S, Temel S, Ozhan N, Çobankara V (2016) The nailfold videocapillaroscopy findings of Behçet’s syndrome. Dermatol Sin 34:74–77

    Article  Google Scholar 

  24. Maldonado G, Guerrero R, Paredes C, Ríos C (2017) Nailfold capillaroscopy in diabetes mellitus. Microvasc Res 112:41–46. https://doi.org/10.1016/j.mvr.2017.03.001

    Article  CAS  PubMed  Google Scholar 

  25. Cutolo M, Melsens K, Wijnant S, Ingegnoli F, Thevissen K, De Keyser F, Decuman S, Müller-Ladner U, Piette Y, Riccieri V, Ughi N, Vandecasteele E, Vanhaecke A, Smith V (2018) Nailfold capillaroscopy in systemic lupus erythematosus: a systematic review and critical appraisal. Autoimmun Rev 17:344–352. https://doi.org/10.1016/j.autrev.2017.11.025

    Article  PubMed  Google Scholar 

  26. Rodriguez-Reyna TS, Bertolazzi C, Vargas-Guerrero A, Gutiérrez M, Hernández-Molina G, PANLAR Capillaroscopy Group (2018) Can nailfold videocapillaroscopy images be interpreted reliably by different observers? Results of an inter-reader and intra-reader exercise among rheumatologists with different experience in this field. Clin Rheumatol. https://doi.org/10.1007/s10067-018-4041-2

  27. Gutierrez M, Bertolazzi C, Tardella M, Becciolini A, DI Carlo M, Dottori M, Grassi W, De Angelis R (2012) Interreader reliability in assessment of nailfold capillary abnormalities by beginners: pilot study of an intensive videocapillaroscopy training program. J Rheumatol 39:1248–1255. https://doi.org/10.3899/jrheum.111299

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Musculoskeletal and Rheumatic Disorders, Instituto Nacional de Rehabilitación - “Luis Guillermo Ibarra Ibarra”, Calzada Mexico-Xochimilco 289, Colonia Arenal de Guadalupe, CP 143898, Mexico City, Mexico

    Chiara Bertolazzi, Denise Clavijo-Cornejo & Marwin Gutierrez

  2. Rheumatology and Dermatology Center of Excellence, Mexico City, Mexico

    Chiara Bertolazzi & Marwin Gutierrez

  3. Department of Rheumatology, Hospital Dr. Dario Fernández Fierro, Mexico City, Mexico

    Selma Gallegos-Nava

  4. Department of Pediatry, Hospital Universitario José Eleuterio Gonzalez, Monterrey, Mexico

    Ana Victoria Villarreal-Treviño

  5. Division of Neurosciences, Instituto Nacional de Rehabilitación, México City, Mexico

    Alfonso Alfaro-Rodriguez

Authors
  1. Chiara Bertolazzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Selma Gallegos-Nava
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ana Victoria Villarreal-Treviño
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alfonso Alfaro-Rodriguez
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Denise Clavijo-Cornejo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Marwin Gutierrez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chiara Bertolazzi.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bertolazzi, C., Gallegos-Nava, S., Villarreal-Treviño, A.V. et al. The current role of capillaroscopy in vasculitides. Clin Rheumatol 38, 2299–2307 (2019). https://doi.org/10.1007/s10067-018-4399-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-018-4399-1

Keywords

Search

Navigation