Clinical Rheumatology

, Volume 38, Issue 4, pp 1125–1130 | Cite as

Effect of interleukin-1 antagonists on the quality of life in familial Mediterranean fever patients

  • Ozkan VaranEmail author
  • Hamit Kucuk
  • Hakan Babaoglu
  • Nuh Atas
  • Reyhan Bilici Salman
  • Hasan Satis
  • Mehmet Akif Ozturk
  • Seminur Haznedaroglu
  • Berna Goker
  • Abdurrahman Tufan
Original Article



Familial Mediterranean fever (FMF) patients suffer from chronic complications of disease such as AA amyloidosis, chronic arthritis, and spondylitis. Reduced quality of life (QoL) is a feature of chronic diseases but it is also impaired in patients with FMF. Despite the regular use of colchicine at a maximal dose, about 10% of patients do not respond well or resistant to colchicine (crFMF). IL-1 inhibitors have been shown to be effective in controlling attacks in crFMF patients. Herein, we aimed to investigate QoL changes of crFMF patients with IL-1 inhibitors.


All patients were prospectively monitored for the frequency, duration, severity of attacks, patient global assessments (Visual Analog Scale; VAS), and laboratory features. Either anakinra or canakinumab was used as IL-1 antagonist treatments. Demographic information, MEFV gene mutations, attack characteristics, and previous treatments were registered. Short form-36 (SF-36) quality of life scale was implemented by the interviewer for evaluating the QoL before and 3 months after the treatment.


A total of 44 patients were included in this study. Striking improvements were detected in frequency, duration, and VAS severity of attacks (p < 0.001). In the comparison of pre- and post-treatment, SF-36 sub-components significant improvements were observed on physical function, role limitation due to physical difficulty, role limitation due to emotional problem, energy, emotional well-being, social function, pain, general health, and health change.


In conclusion, IL-1 antagonists prevent attacks and improve QoL of crFMF.


Anakinra Canakinumab Familial Mediterranean fever IL-1 antagonist Quality of life 


Compliance with ethical standards

For use of IL-1 antagonists, off-label permission was obtained from regulatory authority and local ethics committee approved the study.




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Copyright information

© International League of Associations for Rheumatology (ILAR) 2018

Authors and Affiliations

  • Ozkan Varan
    • 1
    Email author
  • Hamit Kucuk
    • 2
  • Hakan Babaoglu
    • 1
  • Nuh Atas
    • 1
  • Reyhan Bilici Salman
    • 1
  • Hasan Satis
    • 1
  • Mehmet Akif Ozturk
    • 1
  • Seminur Haznedaroglu
    • 1
  • Berna Goker
    • 1
  • Abdurrahman Tufan
    • 1
  1. 1.Faculty of Medicine, Department of Internal Medicine, Division of RheumatologyGazi UniversityAnkaraTurkey
  2. 2.Erzurum Regional Education and Research HospitalErzurumTurkey

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