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Table 4 Adverse events

From: Leflunomide versus cyclophosphamide in the induction treatment of proliferative lupus nephritis in Chinese patients: a randomized trial

Adverse effect LEF (n = 48) CTX (n = 52) P value
  No. % No. %  
Infection 16 33 18 35 NS
 Upper respiratory infection 9 19 9 19  
 Pneumonia 2 4 3 6  
 Urinary tract infection 4 8 3 6  
 Herpes zoster 1 2 3 6  
Leukopenia 1 2 1 2 NS
Elevated liver enzymes 9 18.8 5 9.6 NS
Hair loss 1 2 2 4 NS
Amenorrhea 0 0 2 4 NS
Diarrhea 3 6 3 6 NS
Nausea 1 2 1 2 NS
Hypertension 5 10 1 2 NS
Headache 1 2 3 6 NS
Pyknocardia 2 4 4 8 NS
Death* 1 2 0 1 NS
  1. *One patient died in the leflunomide group because of suicide