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Diagnostic accuracy of miRNAs as potential biomarkers for systemic lupus erythematosus: a meta-analysis

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Abstract

To systematically evaluate the diagnostic accuracy of miRNAs as potential biomarkers for systemic lupus erythematosus (SLE). Studies were searched in PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and China Biology Medicine (CBM) disc database, and languages were limited in English and Chinese. QUADAS-2 tool was applied to assess the quality of eligible studies. Random-effect model was applied to calculate pooled effects of miRNAs on diagnosing SLE. Subgroup analysis was used to explore the sources of heterogeneity. All data were calculated and analyzed by Meta-Disc 1.4 and RevMan 5.3 software. Six eligible studies were included in this meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratio of miRNAs were 0.75(95% CI 0.71–0.79), 0.72(95% CI 0.66–0.78), and 8.79(95% CI 4.91–15.73), respectively. The pooled positive likelihood ratio was 2.71(95% CI 2.20–3.33) and negative likelihood ratio was 0.34(95% CI 0.24–0.48). The area under the curve was 0.787. The subgroup analysis showed that the number of healthy controls might be the sources of heterogeneity. MiRNAs in blood have moderate accuracy and influence on diagnosing SLE, and the exact diagnostic value should be confirmed by further studies.

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Funding

This study was supported by Grants National Natural Science Foundation of China (No. 81573217, 81172764), and Scientific Research of BSKY from Anhui Medical University (No. XJ201301).

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Author notes

  1. Zi-Wei Dai and Hong Wang contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui Province Key Laboratory of Major Autoimmune Diseases, 81 Meishan Road, Hefei, 230032, Anhui, China

    Zi-Wei Dai, Hong Wang, Wen-Juan Xu, Zhi-Hui Wang, Bin Wang & Dong-Qing Ye

  2. Department of Rheumatology and Immunology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui, China

    Sheng-Qian Xu

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  1. Zi-Wei Dai
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  2. Hong Wang
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  4. Zhi-Hui Wang
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Correspondence to Bin Wang or Dong-Qing Ye.

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Dai, ZW., Wang, H., Xu, WJ. et al. Diagnostic accuracy of miRNAs as potential biomarkers for systemic lupus erythematosus: a meta-analysis. Clin Rheumatol 37, 2999–3007 (2018). https://doi.org/10.1007/s10067-018-4189-9

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