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Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study


Resveratrol (RSV), a naturally occurring polyphenol, has been found to have potent antioxidant, anti-inflammatory, and anticancer effects. Recently, RSV was reported as a new potential agent to suppress inflammation of collagen-induced arthritis in a mouse model. Nevertheless, the clinical benefits of RSV in the management of rheumatoid arthritis (RA) were not studied. This randomized controlled clinical trial aims to shed some light on the therapeutic benefits of RSV in the treatment of RA in patients with different stages of the disease activity. In this randomized controlled clinical trial, 100 RA patients (68 female, 32 male) were enrolled randomly and divided into two groups, each of 50 patients: an RSV-treated group that received a daily RSV capsule of 1 g with the conventional treatment for 3 months and a control group that just received the regular treatment. The clinical and biochemical markers of RA in both groups were assessed. It was found that the clinical markers (i.e., the 28-joint count for swelling and tenderness) and the disease activity score assessment for 28 joints were significantly lowered in the RSV-treated group. Moreover, serum levels of certain biochemical markers (i.e., C-reactive protein, erythrocyte sedimentation rate, undercarboxylated osteocalcin, matrix metalloproteinase-3, tumor necrosis factor alpha, and interleukin-6) were also significantly decreased in RSV-treated patients. The current study suggests the addition of RSV as an adjuvant to the conventional antirheumatic drugs.

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The authors thank Assiut University Hospital for the help in using different analytical and research facilities.


This project received financial support from Toxicological Research & Studies Center at Taibah University.

Author information




The authors had design for this study, followed-up RA patients, analyzed data, wrote the manuscript and had full authority to submit the final manuscript. Toxicological Research & Studies Center at Taibah University had only supervised the safety data for this study, with no participation on this study.

Corresponding author

Correspondence to Hani M. Khojah.

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Ethics approval and consent to participate

All RA patients participated in the study gave informed consent and ethical approval for the study was obtained by Institutional Review Board of the Faculty of Medicine at Assiut University.

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Khojah, H.M., Ahmed, S., Abdel-Rahman, M.S. et al. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Clin Rheumatol 37, 2035–2042 (2018).

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  • DAS28-ESR
  • Resveratrol
  • Rheumatoid arthritis
  • TNF-α
  • ucOC