The association between the Mediterranean diet and magnetic resonance parameters for knee osteoarthritis: data from the Osteoarthritis Initiative
- 188 Downloads
The Mediterranean diet appears to be beneficial for osteoarthritis (OA), but the few data available regarding the association between the diet and the condition are limited to X-ray and clinical findings. The current study aimed to investigate the association between adherence to the Mediterranean diet and knee cartilage morphology, assessed using magnetic resonance (MRI) in a cohort of North American participants. Seven hundred eighty-three participants in the Osteoarthritis Initiative (59.8% females; mean age 62.3 years) in possession of a MRI assessment (a coronal 3D FLASH with Water Excitation MR sequence of the right knee) were enrolled in our cross-sectional study. Adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED). The strength of the association between aMED and knee MRI parameters was gauged using an adjusted linear regression analysis, expressed as standardized betas with 95% confidence intervals (CIs). Using an adjusted linear regression analysis, each increase of one standard deviation (SD) in the aMED corresponded to a significant increase in the central medial femoral cartilage volume (beta = 0.12; 95%CI 0.09 to 0.15), in the mean central medial femoral cartilage thickness (beta = 0.13; 95%CI 0.01 to 0.17), in the cartilage thickness of the mean central medial tibiofemoral compartment (beta = 0.12; 95%CI 0.09 to 0.15), and in the cartilage volume of the medial tibiofemoral compartment (beta = 0.09; 95%CI 0.06 to 0.12). Higher adherence to a Mediterranean diet was found to be associated with a significant improvement in knee cartilage as assessed by MRI, even after adjusting for potential confounding factors.
KeywordsAged Healthy aging Knee osteoarthritis Lifestyle Mediterranean diet MRI
Statement of authorship
Analysis and interpretation of data: Veronese, La Tegola. Draft of the article: La Tegola, Crepaldi. Critical revision for important intellectual content: Maggi, Guglielmi. Statistical analysis: Veronese. All authors approved the version submitted.
The OAI is a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health.
Compliance with ethical standards
The OAI study was granted full ethical approval by the institutional review board of the OAI Coordinating Center at University of California, San Francisco.
This manuscript was prepared using an OAI public use dataset and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners. The sponsors had no role in the design, methods, subject recruitment, data collection, analysis, or preparation of this study.
- 1.Hiligsmann M, Cooper C, Arden N, Boers M, Branco JC, Luisa Brandi M, Bruyère O, Guillemin F, Hochberg MC, Hunter DJ, Kanis JA, Kvien TK, Laslop A, Pelletier JP, Pinto D, Reiter-Niesert S, Rizzoli R, Rovati LC, Severens JL(H), Silverman S, Tsouderos Y, Tugwell P, Reginster JY (2013) Health economics in the field of osteoarthritis: an expert’s consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum 43:303–313CrossRefPubMedGoogle Scholar
- 5.Messier SP, Mihalko SL, Legault C, Miller GD, Nicklas BJ, DeVita P, Beavers DP, Hunter DJ, Lyles MF, Eckstein F, Williamson JD, Carr JJ, Guermazi A, Loeser RF (2013) Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA 310:1263–1273CrossRefPubMedPubMedCentralGoogle Scholar
- 7.Veronese N, Stubbs B, Noale M et al (2017) Adherence to a Mediterranean diet is associated with lower prevalence of osteoarthritis: data from the osteoarthritis initiative. Clin Nutr 36:1609–1614Google Scholar
- 12.Cao L, Tan L, Wang H-F, Jiang T, Zhu X-C, Lu H, Tan M-S, Yu J-T (2016) Dietary patterns and risk of dementia: a systematic review and meta-analysis of cohort studies. Mol Neurobiol 53:6144–6154Google Scholar
- 13.Felson DT, Nevitt MC (2004) Epidemiologic studies for osteoarthritis: New versus conventional study design approaches 30:783–797Google Scholar
- 17.Glaser C, Faber S, Eckstein F, Fischer H, Springer V, Heudorfer L, Stammberger T, Englmeier KH, Reiser M (2001) Optimization and validation of a rapid high-resolution T1-w 3D FLASH water excitation MRI sequence for the quantitative assessment of articular cartilage volume and thickness. Magn Reson Imaging 19:177–185CrossRefPubMedGoogle Scholar
- 18.Eckstein F, Kunz M, Schutzer M, Hudelmaier M, Jackson RD, Yu J, Eaton CB, Schneider E (2007) Two year longitudinal change and test-retest-precision of knee cartilage morphology in a pilot study for the osteoarthritis initiative. Osteoarthr Cartil 15:1326–1332CrossRefPubMedPubMedCentralGoogle Scholar
- 23.Miles J (2014) Tolerance and variance inflation factor. In: Balakrishnan N, Colton T, Everitt B, Piegorsch W, Ruggeri F, Teugels JL (eds) Wiley StatsRef: Statistics Reference Online. https://doi.org/10.1002/9781118445112.stat06593
- 25.Chanchek N, Gersing AS, Schwaiger BJ et al (2018) Association of diabetes mellitus and biochemical knee cartilage composition assessed by T2 relaxation time measurements: data from the osteoarthritis initiative. J Magn Reson Imaging 47:380–390Google Scholar
- 27.Guermazi A, Niu J, Hayashi D, Roemer FW, Englund M, Neogi T, Aliabadi P, McLennan CE, Felson DT (2012) Prevalence of abnormalities in knees detected by MRI in adults without knee osteoarthritis: population based observational study (Framingham Osteoarthritis Study). BMJ 345:e5339CrossRefPubMedPubMedCentralGoogle Scholar
- 29.Hunter DJ, Beavers DP, Eckstein F, Guermazi A, Loeser RF, Nicklas BJ, Mihalko SL, Miller GD, Lyles M, DeVita P, Legault C, Carr JJ, Williamson JD, Messier SP (2015) The Intensive Diet and Exercise for Arthritis (IDEA) trial: 18-month radiographic and MRI outcomes. Osteoarthr Cartil 23:1090–1098CrossRefPubMedGoogle Scholar