Regional differences in baseline disease activity and remission rates following golimumab treatment for RA: results from the GO-MORE trial
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GO-MORE (NCT00975130) was a large open-label, multinational, multicenter, prospective phase 3 trial evaluating add-on therapy with golimumab in biologic-naïve patients with active rheumatoid arthritis (RA). The objective of this post hoc analysis was to examine regional differences in baseline disease activity and remission rates following golimumab treatment for RA. This was a planned, descriptive post hoc analysis of data from the GO-MORE trial. Baseline disease activity and remission were defined as moderate or severe based on EULAR criteria. This analysis included 3280 participants from the GO-MORE trial. All participants included in this analysis had high or moderate disease activity at baseline. At baseline, high disease activity was least common in Europe (71.0%), Canada (77.0%), and the Middle East (78.2%) and most common in Latin America (90.7%), South Africa (91.5%), and Asia (92.5%). Month 6 remission rates were highest in South Africa (29.1%), Europe (27.9%), and the Middle East (27.3%) and lowest in Canada (19.7%), Latin America (17.2%), and Asia (15.0%). Higher rates of remission in each geographical region generally corresponded with lower baseline disease activity. We suspect that access to care and implementation of the treat-to-target strategy were the most important determinants, but this apparent relationship needs to be confirmed in further studies that include a statistical analysis of prognostic indicators.
KeywordsAntirheumatic agents Clinical trial Geographic locations Golimumab Rheumatoid arthritis
Medical writing was provided by Dr. Phillip Leventhal (4Clinics, Paris, France) and paid for by MSD. Statistical support was provided by Dr. Ruji Yao (MSD). The GO-MORE study and this analysis were supported by MSD.
Compliance with ethical standards
Conflict of interest
P.D. received fees for participation in speakers’ bureaus for Bristol-Myers Squibb, Samsung, Pfizer, UCB, Mundipharma, Hospira, and Eli Lilly. K.P. received honoraria for speaking and consultations from AbbVie, Pfizer, Roche, Egis, Bristol-Myers Squibb, and MSD. M.D. and N.V. are employees of MSD. All other authors declare no conflict of interest.
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