Clinical Rheumatology

, Volume 37, Issue 5, pp 1273–1280 | Cite as

Atherogenic index of plasma: a useful marker for subclinical atherosclerosis in ankylosing spondylitis

AIP associate with cIMT in AS
  • Erkan Cure
  • Abdullah Icli
  • Ali Ugur Uslu
  • Davut Sakiz
  • Medine Cumhur Cure
  • Rabia Aydogan Baykara
  • Fatma Yavuz
  • Sevket Arslan
  • Adem Kucuk
Original Article


Ankylosing spondylitis (AS) is associated with an increased risk of atherosclerotic cardiovascular disease (ACD). The atherogenic index of plasma (AIP), which is the logarithmic transformation of the plasma triglyceride (TG) level to the high-density lipoprotein level (HDL) ratio, has been suggested to be a novel marker in the identification of atherosclerosis risk. Therefore, this study aims to determine if the AIP can act as an accurate marker for the detection of subclinical atherosclerosis. Fifty-two male patients with AS and 52 age-, gender-, and body mass index (BMI)-matched healthy control subjects were included in the study. For each patient, AIP and total cholesterol (TC)/HDL values were calculated and carotid artery intima-media thickness (cIMT) was measured. The mean (SD) cIMT and median (range) AIP values for AS patients were higher than that of the healthy control subjects (0.60 ± 0.18 vs. 0.51 ± 0.10, p = 0.003 and 0.23 [− 0.32 to 0.85] vs. 0.09 [− 0.53 to 0.49], p = 0.007, respectively). A positive correlation was found between the patients’ cIMT and AIP values (r = 0.307, p = 0.002) and TC/HDL values (r = 0.241, p = 0.014). Regression analysis revealed an independent association between the subclinical atherosclerosis and AIP (beta [β] = 0.309, p = 0.002). There were no independent correlations between subclinical atherosclerosis and TC (β = 0.245, p = 0.065), TG (β = 0.185, p = 0.515), HDL (β = 0.198, p = 0.231), TC/HDL (β = 0.032, p = 0.862), and low-density lipoprotein (LDL) (β = 0.151, p = 0.246). A strong and independent correlation exists between AIP and cIMT values. Therefore, the AIP could serve as a better marker than the TC/HDL ratio for the detection of subclinical atherosclerosis in AS patients.


Ankylosing spondylitis Atherogenic index of plasma Carotid intima-media thickness Subclinical atherosclerosis 


Compliance with ethical standards

Ethics approval for the study was obtained from the Institutional Review Board at the Necmettin Erbakan University School of Medicine. Signed approval forms were taken from the subjects who participated in the study. This study was conducted in accordance with the updated Declaration of Helsinki.


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Copyright information

© International League of Associations for Rheumatology (ILAR) 2018

Authors and Affiliations

  1. 1.Department of Internal MedicineCamlica Erdem HospitalIstanbulTurkey
  2. 2.Department of CardiologyNecmettin Erbakan UniversityKonyaTurkey
  3. 3.Department of Internal MedicineYunus Emre State HospitalEskisehirTurkey
  4. 4.Department of Endocrinology and Metabolism, Diskapi Training and Research HospitalUniversity of Health SciencesAnkaraTurkey
  5. 5.Department of BiochemistryIstanbul LaboratoryIstanbulTurkey
  6. 6.Department of Physical Medicine and RehabilitationMalatya Training and Research HospitalMalatyaTurkey
  7. 7.Department of Internal MedicineDogubeyazit Doc. Dr. Yasar Eryilmaz State HospitalAgriTurkey
  8. 8.Division of Allergy and Clinical ImmunologyKonya Training and Research HospitalKonyaTurkey
  9. 9.Division of Rheumatology, Department of Internal MedicineNecmettin Erbakan UniversityKonyaTurkey

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