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Evaluation of the effects of miRNAs in familial Mediterranean fever

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A Correction to this article was published on 07 January 2019

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Abstract

Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder that can result in attacks with accompanying recurrent episodes of fever, serositis, and skin rash. MiRNAs are demonstrated to be associated with a number of other diseases; however, no comprehensive study has revealed its association with FMF disease. The aim is to investigate the role of microRNAs in FMF. We included 51 patients with genetically diagnosed FMF who had clinical symptoms and 49 healthy volunteers. Fifteen miRNAs that were found to be associated with autoinflammatory diseases and have a part in immune response were evaluated. The expression levels of 11 miRNAs (miR-125a, miR-132, miR-146a, miR-155, miR-15a, miR-16, miR-181a, miR-21, miR-223, miR-26a, and miR-34a) in the patient group were significantly low, compared with the control group (p < 0.05). The patient group was analyzed and compared within itself, and the expression levels of 5 miRNAs (miR-132, miR-15a, miR-181a, miR-23b, miR-26a) in the patients who took colchicine seemed to have increased and levels of 5 miRNAs (miR-146a, miR-15a, miR-16, miR-26a, miR-34a) in the patients who took colchicine were significantly lower (p < 0.05). Furthermore, the attack patients were compared with the control group, and their expression levels of 4 miRNAs (miR-132, miR-15a, miR-21, miR-34a) were significantly lower (p < 0.05). Levels of 9 miRNAs (miR-132, miR-146a, miR-15a, miR-16, miR-181a, miR-21, miR-223, miR-26a, miR-34a) in non-attack patients decreased significantly (p < 0.05). Our study demonstrates that miRNAs could be effective in the pathogenesis of FMF.

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Change history

  • 07 January 2019

    The name of the last author of this article was incorrectly presented as “Cogulu Ozgur” this should have been “Ozgur Cogulu”.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Pediatrics, Ege University, Izmir, Turkey

    Hacer Orsdemir Hortu & Tahir Atik

  2. Faculty of Medicine, Department of Medical Genetic, Ege University, Izmir, Turkey

    Emin Karaca, Ismihan Merve Tekin & Ozgur Cogulu

  3. Istanbul Umraniye Training and Research Hospital, Istanbul, Turkey

    Betul Sozeri

  4. Izmir Dr. Behcet Uz Children’s Diseases and Surgery Training and Research Hospital, Izmir, Turkey

    Nesrin Gulez

  5. Faculty of Medicine, Department of Pediatrics, 9 Eylul University, Izmir, Turkey

    Balahan Makay & Sevket Erbil Unsal

  6. Faculty of Medicine, Department of Medical Biology, Ege University, Izmir, Turkey

    Cumhur Gunduz

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  1. Hacer Orsdemir Hortu
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  2. Emin Karaca
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  10. Ozgur Cogulu
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Correspondence to Emin Karaca.

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The current study received ethical approval from the university’s departmental ethics committee.

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The original version of this article was revised: The name of the second author of this article was incorrectly presented as “Cogulu Ozgur” this should have been “Ozgur Cogulu".

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Hortu, H.O., Karaca, E., Sozeri, B. et al. Evaluation of the effects of miRNAs in familial Mediterranean fever. Clin Rheumatol 38, 635–643 (2019). https://doi.org/10.1007/s10067-017-3914-0

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