Skip to main content
Log in

Digital tomosynthesis as a new diagnostic tool for assessing of chronic gout arthritic feet and ankles: comparison of plain radiography and computed tomography

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

This aimed to compare the three radiographic methods of digital tomosynthesis (DT), plain radiography, and computed tomography (CT) for evaluating changes in feet of patients with chronic gouty arthritis. Two independent radiologists read the plain radiography, DT, and CT images of 30 male patients with gout. The degrees of erosion and joint space narrowing were scored using the Sharp–van der Heijde scoring method in 18 foot joints, which consisted of four proximal interphalangeal and one interphalangeal joint of the first toe, five metatarsophalangeal, five tarsometatarsal, and three naviculo-cuneiform joints of the foot. DT showed high reproducibility [0.929 for intraobserver intraclass correlation coefficient (ICC) and 0.838 for interobserver ICC]. DT showed similar results to those of CT and superior results to those of plain radiography for evaluating radiographic damage [mean total score, 8.5 ± 14.6 (±standard deviation) for plain radiography, 12.9 ± 12.4 for DT, and 12.6 ± 11.2 for CT]. This study showed that DT is a good method for evaluating radiographic changes in patients with gout. Further research is needed to apply DT to actual clinical settings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Choi HK, Mount DB, Reginato AM (2005) Pathogenesis of gout. Ann Intern Med 143:499–516

    Article  CAS  PubMed  Google Scholar 

  2. McQueen FM, Chhana A, Dalbeth N (2012) Mechanisms of joint damage in gout: evidence from cellular and imaging studies. Nat Rev Rheumatol 8:173–181

    Article  CAS  PubMed  Google Scholar 

  3. Dalbeth N, Collis J, Gregory K, Clark B, Robinson E, McQueen FM (2007) Tophaceous joint disease strongly predicts hand function in patients with gout. Rheumatology (Oxford) 46:1804–1807

    Article  CAS  Google Scholar 

  4. Kavanaugh A, Han C, Bala M (2004) Functional status and radiographic joint damage are associated with health economic outcomes in patients with rheumatoid arthritis. J Rheumatol 31:849–855

    PubMed  Google Scholar 

  5. Perez-Ruiz F, Martinez-Indart L, Carmona L, Herrero-Beites AM, Pijoan JI, Krishnan E (2014) Tophaceous gout and high level of hyperuricemia are both associated with increased risk of mortality in patients with gout. Ann Rheum Dis 73:177–182

    Article  CAS  PubMed  Google Scholar 

  6. Dalbeth N, Clark B, Gregory K, Gamble G, Sheehan T, Doyle A et al (2009) Mechanisms of bone erosion in gout: a quantitative analysis using plain radiography and computed tomography. Ann Rheum Dis 68:1290–1295

    Article  CAS  PubMed  Google Scholar 

  7. Ogdie A, Taylor WJ, Weatherall M, Fransen J, Jansen TL, Neogi T et al (2015) Imaging modalities for the classification of gout: systematic literature review and meta-analysis. Ann Rheum Dis 74:1868–1874

    Article  PubMed  Google Scholar 

  8. McQueen FM, Doyle A, Reeves Q, Gao A, Tsai A, Gamble GD et al (2014) Bone erosions in patients with chronic gouty arthropathy are associated with tophi but not bone oedema or synovitis: new insights from a 3 T MRI study. Rheumatology (Oxford) 53:95–103

    Article  Google Scholar 

  9. McAdams HP, Samei E, Dobbins J 3rd, Tourassi GD, Ravin CE (2006) Recent advances in chest radiography. Radiology 241:663–683

    Article  PubMed  Google Scholar 

  10. Dobbins JT 3rd, Godfrey DJ (2003) Digital x-ray tomosynthesis: current state of the art and clinical potential. Phys Med Biol 48:R65–106

    Article  PubMed  Google Scholar 

  11. Canella C, Philippe P, Pansini V, Salleron J, Flipo RM, Cotten A (2011) Use of tomosynthesis for erosion evaluation in rheumatoid arthritic hands and wrists. Radiology 258:199–205

    Article  PubMed  Google Scholar 

  12. Aoki T, Fujii M, Yamashita Y, Takahashi H, Oki H, Hayashida Y et al (2014) Tomosynthesis of the wrist and hand in patients with rheumatoid arthritis: comparison with radiography and MRI. AJR Am J Roentgenol 202:386–390

    Article  PubMed  Google Scholar 

  13. Dalbeth N, Gao A, Roger M, Doyle AJ, McQueen FM (2014) Digital tomosynthesis for bone erosion scoring in gout: comparison with plain radiography and computed tomography. Rheumatology (Oxford) 53:1712–1713

    Article  Google Scholar 

  14. Roddy E (2011) Revisiting the pathogenesis of podagra: why does gout target the foot? J Foot Ankle Res 4:13

    Article  PubMed  PubMed Central  Google Scholar 

  15. Wallace SL, Robinson H, Masi AT, Decker JL, McCarty DJ, Yu TF (1977) Preliminary criteria for the classification of the acute arthritis of primary gout. Arthritis Rheum 20:895–900

    Article  CAS  PubMed  Google Scholar 

  16. van der Heijde D (1999) How to read radiographs according to the Sharp/van der Heijde method. J Rheumatol 26:743–745

    PubMed  Google Scholar 

  17. Dalbeth N, Clark B, McQueen F, Doyle A, Taylor W (2007) Validation of a radiographic damage index in chronic gout. Arthritis Rheum 57:1067–1073

    Article  PubMed  Google Scholar 

  18. Shrout PE, Fleiss JL (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–428

    Article  CAS  PubMed  Google Scholar 

  19. Hallgren KA (2012) Computing inter-rater reliability for observational data: an overview and tutorial. Tutor Quant Methods Psychol 8:23–34

    Article  PubMed  PubMed Central  Google Scholar 

  20. Zhu Y, Pandya BJ, Choi HK (2011) Prevalence of gout and hyperuricemia in the US general population: the National Health and nutrition examination survey 2007-2008. Arthritis Rheum 63:3136–3141

    Article  PubMed  Google Scholar 

  21. Simoni P, Gerard L, Kaiser MJ, Ribbens C, Rinkin C, Malaise O et al (2015) Use of tomosynthesis for detection of bone erosions of the foot in patients with established rheumatoid arthritis: comparison with radiography and CT. AJR Am J Roentgenol 205:364–370

    Article  PubMed  Google Scholar 

  22. Kim SK, Lee H, Kim JH, Park SH, Lee SK, Choe JY (2013) Potential interest of dual-energy computed tomography in gout: focus on anatomical distribution and clinical association. Rheumatology (Oxford) 52:402–403

    Article  Google Scholar 

  23. Xia W, Yin XR, Wu JT, Wu HT (2013) Comparative study of DTS and CT in the skeletal trauma imaging diagnosis evaluation and radiation dose. Eur J Radiol 82:e76–e80

    Article  PubMed  Google Scholar 

  24. Son CN, Kim TE, Park K, Hwang JH, Kim SK (2016) Simplified radiographic damage index for affected joints in chronic gouty arthritis. J Korean Med Sci 31:435–442

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jae-Bum Jun.

Ethics declarations

Ethics approval was obtained from the Institutional Review Board of Hanyang University Hospital for Rheumatic Diseases. Written informed consent was obtained from all participants and confirmed by the board.

Funding

This work was supported by the research fund of Hanyang University (HY-2014).

Disclosures

None.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Son, CN., Song, Y., Kim, SH. et al. Digital tomosynthesis as a new diagnostic tool for assessing of chronic gout arthritic feet and ankles: comparison of plain radiography and computed tomography. Clin Rheumatol 36, 2095–2100 (2017). https://doi.org/10.1007/s10067-017-3710-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-017-3710-x

Keywords

Navigation