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Are obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?

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Abstract

The aim of this study was to investigate the body mass index (BMI), anti-citrullinated protein antibodies (ACPAs) status and the presence of periodontitis and IgG-1/IgG-2 antibodies against Porphyromonas gingivalis (Pg) in the first-degree relatives (FDRs) of rheumatoid arthritis (RA) patients and compare these variables with a control group of healthy individuals from the general population. In total, 100 FDR individuals and 200 healthy controls matched by age and gender were included. Rheumatologic and periodontal assessment was performed, and the presence of ACPAs and anti-P. gingivalis antibodies was evaluated. Groupwise comparisons were analysed using the McNemar and Wilcoxon tests. A conditional logistic regression analysis was performed to establish the associations between BMI, ACPAs and periodontitis in both groups. In the FDR group, 70% of the subjects were female, with a mean age of 37.3 ± 13 years. Obesity was observed in 17 and 7% of the FDRs and controls, respectively. ACPAs were found in 7% of the FDRs vs. 2.5% of the controls. Periodontitis was diagnosed in 79 and 56% of the FDRs and controls, respectively. Among the FDRs, 15% had severe periodontitis. There were associations in the FDR group related to the presence of obesity (OR 2.93, 95% CI 1.03–8.28), ACPAs (OR 2.45, 95% CI 0.7–8.32) and periodontitis (OR 3.70 95% CI 1.89–7.29). Regarding anti-P. gingivalis antibodies and smoking history, no differences were found between the groups. Obesity, ACPAs and periodontitis (diagnosis and severity) can be considered as relevant conditions associated with the development of RA in FDRs.

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References

  1. Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423:356–361

    Article  CAS  PubMed  Google Scholar 

  2. van de Stadt LA, van der Horst AR, de Koning MH, Bos WH, Wolbink GJ, van de Stadt RJ et al (2011) The extent of the anticitrullinated protein antibody repertoire is associated with arthritis development in patients with seropositive arthralgia. Ann Rheum Dis 70:128–133

    Article  PubMed  Google Scholar 

  3. van de Sande MG, de Hair MJ, van der Leij C, Klarenbeek PL, Bos WH, Smith MD et al (2011) Different stages of rheumatoid arthritis: features of the synovium in the preclinical phase. Ann Rheum Dis 70:772–777

    Article  PubMed  Google Scholar 

  4. Gerlag DM, Raza K, van Baarsen LG, Brouwer E, Buckley CD, Burmester GR et al (2012) EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis: report from the Study Group for Risk Factors for Rheumatoid Arthritis. Ann Rheum Dis 71:638–641

    Article  PubMed  PubMed Central  Google Scholar 

  5. Frommer KW, Schäffler A, Büchler C, Steinmeyer J, Rickert M, Rehart S et al (2012) Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis? Ann Rheum Dis 71:1724–1732

    Article  CAS  PubMed  Google Scholar 

  6. Ronti T, Lupattelli G, Mannarino E (2006) The endocrine function of adipose tissue: an update. Clin Endocrinol 64:355–365

    CAS  Google Scholar 

  7. Kim S, Moustaid-Moussa N (2000) Secretory, endocrine and autocrine/paracrine function of the adipocyte. J Nutr 130:3110–315S

    Google Scholar 

  8. Tilg H, Moschen AR (2006) Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6:772–783

    Article  CAS  PubMed  Google Scholar 

  9. Giles JT, van der Heijde DM, Bathon JM (2011) Association of circulating adiponectin levels with progression of radiographic joint destruction in rheumatoid arthritis. Ann Rheum Dis 70:1562–1568

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Ebina K, Fukuhara A, Ando W, HiraoM KT, Oshima K et al (2009) Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction. Clin Rheumatol 28:445–451

    Article  PubMed  Google Scholar 

  11. Wegner N, Lundberg K, Kinloch A et al (2010) Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev 233:34–54

    Article  CAS  PubMed  Google Scholar 

  12. van Gaalen F, Ioan-Facsinay A, Huizinga TW, Toes RE (2005) The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis. J Immunol 175:5575–5580

    Article  PubMed  Google Scholar 

  13. Deane KD (2012) Learning about the natural history of rheumatoid arthritis development through prospective study of subjects at high risk of rheumatoid arthritis-related autoimmunity. Arthritis Rheum 64:1708–1712

    Article  PubMed  PubMed Central  Google Scholar 

  14. Mikuls TR, Thiele GM, Deane KD, Payne JB, O′Dell JR, Yu F, et al. Porphyromonas gingivalis and disease related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum 2012;64:3522–3530

  15. Pischon N, Pischon T, Kröger J, Gülmez E, Kleber BM, Bernimoulin JP et al (2008) Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol 79:979–986

    Article  CAS  PubMed  Google Scholar 

  16. Bello-Gualtero JM, Lafaurie GI, Hoyos LX, Castillo DM, De-Avila J, Munevar JC et al (2016) Periodontal disease in individual a genetic risk of developing arthritis and early rheumatoid arthritis: a cross-sectional study. J Periodontol 87:346–356

    Article  PubMed  Google Scholar 

  17. Tonetti MS, Claffey N (2005) European Workshop in Periodontology group C. Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. J Clin Periodontol 32:210–213

    Article  PubMed  Google Scholar 

  18. Page RC, Eke PI (2007) Case definitions for use in population-based surveillance of periodontitis. J Periodontol 78:1387–1399

    Article  PubMed  Google Scholar 

  19. World Health Organization (2015) Obesity: preventing and managing the global epidemic. Report of a WHO consulation. World Health Organ Tech Rep Ser 894:8

    Google Scholar 

  20. Yarwood A, Huizinga TW, Worthington J (2016) The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA. Rheumatology (Oxford) 55:199–209

    Article  Google Scholar 

  21. Jutley G, Raza K, Buckley CD (2015) New pathogenic insights into rheumatoid arthritis. Curr Opin Rheumatol 27:249–255

    Article  CAS  PubMed  Google Scholar 

  22. Sandberg MEC, Bengtsson C, Källberg H, Wesley A, Klareskoq L, Alfredsson L et al (2014) Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis. Ann Rheum Dis 73:2029–2033

    Article  PubMed  Google Scholar 

  23. Baker JF, Ostergaard M, George M, Shults J, Emery P, Baker DG et al (2014) Greater body mass independently predicts less radiographic progression on X-ray and MRI over 1–2 years. Ann Rheum Dis 73:1923–1928

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lu B, Hiraki L, Sparks JA, Malspeis S, Chen CY, Awosoqba JA et al (2014) Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study. Ann Rheum Dis 73:1914–1922

    Article  PubMed  PubMed Central  Google Scholar 

  25. Wesley A, Bengtsson C, Elkan AC, Klareskog L, Alfredsson L, Wedrén S (2013) Association between body mass index and anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis: results from a population-based case-control study. Arthritis Care Res 65:107–101

    Article  Google Scholar 

  26. Finckh A, Turesson C (2014) The impact of obesity on the development and progression of rheumatoid arthritis. Ann Rheum Dis 73:1911–1913

    Article  PubMed  Google Scholar 

  27. Trayhurn P, Wood IS (2005) Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 33:1078–1081

    Article  CAS  PubMed  Google Scholar 

  28. Soriano-Guillen L, Hernández-García B, Pita J, Domínguez-Garrido N, Del Río-Camacho G, Rovira A (2008) High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese and adolescents. Eur J Endocrinol 159:R1–R4

    Article  CAS  PubMed  Google Scholar 

  29. Deane KD, O’Donnell CI, Hueber W, Majika DS, Lazar AA, Derber LA et al (2010) The number of elevated cytokines and chemokines in preclinical seropositive rheumatoid arthritis predicts time to diagnosis in an age-dependent manner. Arthritis Rheum 62:3161–3172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Kokkonen H, Soderstrom I, Rocklov J, Hallmans G, Lejon K, Rantapää S (2010) Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum 62:383–391

    CAS  PubMed  Google Scholar 

  31. Karlson EW, Chibnik LB, Tworoger SS, Lee IM, Buring JE, Shadick NA et al (2009) Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum 60:641–652

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Alvarez-Nemegyei J, Buenfil-Rello FA, Pacheco-Pantoja EL (2016) Asociación entre composición corporal y actividad inflamatoria en artritis reumatoide. Una revisión sistemática. Reumatol Clin 12:190–195

    Article  PubMed  Google Scholar 

  33. Dissick A, Redman RS, Jones M et al (2010) Association of periodontitis with rheumatoid arthritis: a pilot study. J Periodontol 81:223–230

    Article  PubMed  Google Scholar 

  34. Lundberg K, Wegner N, Yucel-Lindberg T, Venables PJ (2010) Periodontitis in RA the citrullinated enolase connection. Nat Rev Rheumatol 6:727–730

    Article  CAS  PubMed  Google Scholar 

  35. Bright R, Proudman SM, Rosenstein ED, Bartold PM (2015) Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis? Med Hypotheses 84:570–576

    Article  CAS  PubMed  Google Scholar 

  36. Lafaurie G, Contreras A, Barón A, Botero J, Mayorga-Fayad I, Jaramillo A et al (2007) Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicentre study. J Periodontol 78:629–639

    Article  PubMed  Google Scholar 

  37. Botero JE, Contreras A, Lafaurie G, Jaramillo A, Betancourt M, Arce RM (2007) Occurrence of periodontopathic and superinfecting bacteria in chronic and aggressive periodontitis subjects in a Colombian population. J Periodontol 78:696–704

    Article  PubMed  Google Scholar 

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Acknowledgements

This study was supported by the Universidad El Bosque (PCI 2013-469), the Hospital Militar Central (2013-048), and the Government Institute of Science, Technology, and Innovation, Francisco Jose de Caldas—COLCIENCIAS (Grant No. 130854531734-2011 and 130865740792).

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Correspondence to Sonia Unriza-Puin.

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The study subjects provided written informed consent. The institutional ethics committee approved the study: Universidad El Bosque (PCI 2014-469) and Hospital Militar Central (2013-048).

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Unriza-Puin, S., Bautista-Molano, W., Lafaurie, G.I. et al. Are obesity, ACPAs and periodontitis conditions that influence the risk of developing rheumatoid arthritis in first-degree relatives?. Clin Rheumatol 36, 799–806 (2017). https://doi.org/10.1007/s10067-016-3519-z

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  • DOI: https://doi.org/10.1007/s10067-016-3519-z

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