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National survey of pediatric hospitalizations due to Kawasaki disease and coronary artery aneurysms in the USA

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Abstract

Several studies revealed the epidemiology of Kawasaki disease-related hospitalizations among children in the USA and other countries. However, disparities of developing coronary artery aneurysms by race/ethnicity, patient socioeconomic status, and geographic locations remain unknown in the USA. Hospital discharge record data of patients with Kawasaki disease aged 19 years or younger were obtained from the 2003, 2006, 2009, and 2012 Kid’s Inpatient Database. The data were weighted to estimate the annual hospitalization rates with respect to age, gender, and race/ethnicity in the USA. Multivariable logistic regression was conducted to ascertain the factors associated with the development of coronary artery aneurysms. Total annual hospitalization rates of Kawasaki disease showed a decreasing trend, ranging from 6.54 per 100,000 children in 2003 to 6.11 per 100,000 children in 2012 (p < 0.001). The proportions of coronary artery aneurysms among patients with Kawasaki disease ranged from 2.25 to 3.20%. Factor associated with the development of coronary artery aneurysms was hospitals in West (OR 2.15, 95% CI 1.42–3.26). Race/ethnicity, health insurance status, and household income were not associated with the development of coronary artery aneurysms. Total hospitalization rates of Kawasaki disease showed a decreasing trend. Children admitted to hospitals in West region were more likely to develop coronary artery aneurysms.

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Authors and Affiliations

  1. Harvard T.H. Chan School of Public Health, 158 Longwood Avenue, Boston, 02115, USA

    Yusuke Okubo, Kotaro Nochioka & Marcia Testa

  2. Department of General Pediatrics, National Center for Child Health and Development, Tokyo, Japan

    Yusuke Okubo

  3. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

    Kotaro Nochioka

  4. Department of General Pediatrics, Tokyo Metropolitan Children’s Medical Center, Tokyo, Japan

    Hiroshi Sakakibara

  5. Division of Immunology, Boston Children’s Hospital, Boston, MA, 02115, USA

    Robert P. Sundel

Authors
  1. Yusuke Okubo
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  2. Kotaro Nochioka
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  3. Hiroshi Sakakibara
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  4. Marcia Testa
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  5. Robert P. Sundel
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Correspondence to Yusuke Okubo.

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Okubo, Y., Nochioka, K., Sakakibara, H. et al. National survey of pediatric hospitalizations due to Kawasaki disease and coronary artery aneurysms in the USA. Clin Rheumatol 36, 413–419 (2017). https://doi.org/10.1007/s10067-016-3512-6

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  • DOI: https://doi.org/10.1007/s10067-016-3512-6

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