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Circulating Dickkopf-1 and sclerostin in patients with Paget’s disease of bone

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Abstract

Paget disease of bone is a chronic metabolic bone disorder characterized by increased bone resorption and new bone formation. The aim of this study is defining the role of inhibitors of canonical Wnt/b-catenin signaling pathway in patients with Paget disease of bone. Scarce and contrasting results have been reported in literature. We studied 40 patients (15 females and 25 males) with radiological and scintigraphic evidence of Paget disease of bone and 40 healthy subjects matched by age and sex. N-propeptide of type I collagen, C-terminal telopeptide of type I collagen, sclerostin, and Dickkopf-related protein 1 (DKK1) were evaluated by blood samples in our laboratory. As expected, mean serum levels of bone turnover markers (N-propeptide of type I collagen and C-terminal telopeptide of type I collagen) were significantly higher in the Paget disease of bone group compared with the control group. No difference was observed between groups in Dickkopf-1 and sclerostin. Dickkopf-1 and sclerostin were never correlated with each other or with bone turnover markers. Sclerostin was positively correlated with age. In conclusion, our results suggest that the regulators of the Wnt-β catenin pathway are not altered in patients with Paget disease of bone. The positive correlation we found between sclerostin and age in Paget disease of bone patients indicates that in comparative studies, sclerostin serum levels must be adjusted for age.

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Acknowledgements

We thank Caterina Fraccarollo and Cristina Bosco for the ELISA assays.

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Authors and Affiliations

  1. Rheumatology Unit, University of Verona, Verona, Italy

    Luca Idolazzi, Angelo Fassio, Gaia Tripi, Vania Braga, Ombretta Viapiana, Giovanni Adami, Maurizio Rossini & Davide Gatti

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  1. Luca Idolazzi
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  2. Angelo Fassio
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  3. Gaia Tripi
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  4. Vania Braga
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  5. Ombretta Viapiana
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  6. Giovanni Adami
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  7. Maurizio Rossini
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  8. Davide Gatti
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Correspondence to Luca Idolazzi.

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Conflict of interest

Dr. Idolazzi reports personal fees from Abbvie, personal fees from Novartis, personal fees from Eli Lilly, and personal fees from UCB, outside the submitted work.

Dr. Fassio has nothing to disclose.

Dr. Tripi has nothing to disclose.

Dr. Braga has nothing to disclose.

Dr. Viapiana reports personal fees from Abiogen, personal fees from Amgen, and personal fees from Merck Sharp & Dohme Corp, outside the submitted work.

Dr. Adami has nothing to disclose.

Prof. Rossini reports personal fees from Abiogen, personal fees from Amgen, personal fees from Merck Sharp & Dohme Corp, and personal fees from Eli Lilly, outside the submitted work.

Prof. Gatti reports personal fees from Abiogen, personal fees from Amgen, personal fees from Merck Sharp & Dohme Corp, and personal fees from Eli Lilly, outside the submitted work.

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Idolazzi, L., Fassio, A., Tripi, G. et al. Circulating Dickkopf-1 and sclerostin in patients with Paget’s disease of bone. Clin Rheumatol 36, 925–928 (2017). https://doi.org/10.1007/s10067-016-3497-1

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  • DOI: https://doi.org/10.1007/s10067-016-3497-1

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