Clinical Rheumatology

, Volume 35, Issue 11, pp 2749–2756 | Cite as

Nationwide epidemiological survey of childhood IgA vasculitis associated hospitalization in the USA

  • Yusuke OkuboEmail author
  • Kotaro Nochioka
  • Hiroshi Sakakibara
  • Hiroshi Hataya
  • Toshiro Terakawa
  • Marcia Testa
  • Robert P Sundel
Original Article


At the national level, IgA vasculitis-related hospitalizations among children in the USA are scarce. Furthermore, nationwide epidemiology and hospital course of children with IgA vasculitis have not been fully described in the USA, and disparities by race/ethnicity remain unknown. Hospital discharge records of patients aged 19 years or younger were obtained from the 2003, 2006, 2009, and 2012 Kids’ Inpatient Database, and they were weighted to estimate the annual hospitalization rates with respect to age, gender, and race/ethnicity in the USA. Annual hospitalization rates were calculated using weighted case estimates and US census data. Negative binomial regression was used to ascertain the factors associated with length of hospital stay. Total annual hospitalization rates showed a significant decreasing trend, ranging from 2.45 per 100,000 children in 2003 to 1.89 per 100,000 children in 2012 (p < 0.001). The peak ages of the hospitalized children with IgA vasculitis were 2 and 7 years, and male-to-female ratios were 1.38–1.44. Factors associated with length of hospital stay were patients’ ages (10–14 and 15–19 years), race/ethnicity (Hispanic, Asian, and Pacific Islander), comorbid electrolyte abnormality, GI hemorrhage, intussusception, renal symptoms, and GI symptoms. The annual hospitalization rates for IgA vasculitis are declining in the USA across multiple age groups. GI and renal manifestations are associated with increased length of hospital stay.


Epidemiology IgA vasculitis Kids’ Inpatient Database The USA 


Compliance with ethical standards

Financial disclosure

The authors have no financial relationships relevant to this article to disclose.

Funding source

The authors have no research or project support, including internal funding.



Supplementary material

10067_2016_3402_MOESM1_ESM.docx (46 kb)
Supplement 1 (DOCX 45 kb)
10067_2016_3402_MOESM2_ESM.docx (59 kb)
Supplement 2 (DOCX 59 kb)


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Copyright information

© International League of Associations for Rheumatology (ILAR) 2016

Authors and Affiliations

  • Yusuke Okubo
    • 1
    • 2
    • 3
    Email author
  • Kotaro Nochioka
    • 1
  • Hiroshi Sakakibara
    • 2
  • Hiroshi Hataya
    • 2
  • Toshiro Terakawa
    • 2
  • Marcia Testa
    • 1
  • Robert P Sundel
    • 4
  1. 1.Harvard T.H. Chan School of Public HealthBostonUSA
  2. 2.Department of General PediatricsTokyo Metropolitan Children’s Medical CenterTokyoJapan
  3. 3.Harvard School of Public HealthBostonUSA
  4. 4.Division of ImmunologyBoston Children’s HospitalBostonUSA

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