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Fraction of exhaled nitric oxide as a predictor in juvenile idiopathic arthritis progression

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Abstract

In this study, the relation between the nitric oxide (NO) levels in the serum and fraction of exhaled nitric oxide (FENO) in children with juvenile idiopathic arthritis (JIA) and the activation criteria of the disease has been investigated. The study group consisted of 35 JIA-diagnosed patients and 18 healthy children. According to the clinical and laboratory findings, the patients with JIA were divided into two groups, active (group I) and in remission (group II). The healthy children were classified as group III. The activation criteria of the disease were determined for each patient. The serum NO level and FENO level were measured in all the patients. In the group with JIA, correlation was detected between FENO level and number of involved joints and number of joints with limited motion. In addition, correlation was determined between the FENO level and number of involved joints in group I and the serum NO level and activity score in group II. However, it was seen that there is no statistical difference in the serum NO level and FENO level of the patients with JIA and the control group and groups I and II. This study demonstrated the correlation between FENO level and number of involved joints and number of joints with limited motion in patients with JIA. Our results matter in terms of FENO being a noninvasive laboratory marker in following the progression of the disease.

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Authors and Affiliations

  1. Department of Pediatric Allergy and Immunology, Çukurova University Faculty of Medicine, Adana, Turkey

    Dilek Doğruel, Mustafa Yılmaz, Gülbin Bingöl, Derya Ufuk Altıntaş & Seval Güneşer Kendirli

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  1. Dilek Doğruel
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  2. Mustafa Yılmaz
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  3. Gülbin Bingöl
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  4. Derya Ufuk Altıntaş
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  5. Seval Güneşer Kendirli
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Correspondence to Dilek Doğruel.

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Funding

This study was approved by Çukurova University Institutional Review Board and Ethics Committee (Project no: TF2005LTP26) and supported by Çukurova University Research Fund.

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Authors’ contributions

Dilek Doğruel and Mustafa Yılmaz participated in research design, data collection and interpretation, writing of the paper, performance of research, and data analysis. Dr. Bingöl, Dr. Altıntaş, and Dr. Kendirli contributed to the study concept.

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Doğruel, D., Yılmaz, M., Bingöl, G. et al. Fraction of exhaled nitric oxide as a predictor in juvenile idiopathic arthritis progression. Clin Rheumatol 36, 541–546 (2017). https://doi.org/10.1007/s10067-016-3371-1

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  • DOI: https://doi.org/10.1007/s10067-016-3371-1

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