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Relationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever

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Abstract

Recent studies have shown that genetic factors involved in the host responses might determine the disease severity for both familial Mediterranean fever (FMF) and periodontitis. The present study aimed to investigate the relationship of FMF with periodontitis and to search for the potential association between periodontitis and MEFV gene missense variations in patients with FMF. The study consisted of 97 FMF patients and 34 healthy volunteers. FMF patients were classified according to the kind of MEFV gene mutation: (1) patients with homozygous M694V gene mutation, (2) patients with heterozygous M694V gene mutation, and (3) patients with MEFV gene different mutations. Gingival Index (GI), Plaque Index (PI), probing pocket depth (PD), and clinical attachment level (CAL) were measured in all participants. The results of multivariate logistic regression showed a highly significant association between homozygous M694V gene mutation and periodontitis in FMF patients (p < 0.05). After adjusting for potential confounders (smoking, body weight, age, and gender), FMF patients with homozygous M694V gene mutation were 3.51 (1.08–11.45) times more likely to present periodontitis than the other FMF patients. These results indicate that the presence of homozygous M694V gene mutation seems to increase the risk for periodontitis in FMF patients.

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Compliance with ethical standards

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Ethics approval

The study was approved by the Ethical Committee for the Use of Human Subjects in Research, Gaziantep University, Gaziantep (protocol number: 22.01.13/30).

Consent to participate

Written informed consent form was signed by all participants before the study.

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Authors and Affiliations

  1. Department of Periodontology, Bezmialem Vakif University, Faculty of Dentistry, İstanbul, Turkey

    Ufuk Sezer

  2. Department of Periodontology, Gaziantep University, Faculty of Dentistry, Gaziantep, Turkey

    Süleyman Ziya Şenyurt & Kamile Erciyas

  3. Ministry of Health, Center of Oral and Dental Health, Kahramanmaraş, Turkey

    Eda Çetin Özdemir

  4. Department of Rheumatology, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey

    Orhan Zengin, Bünyamin Kısacık & Ahmet Mesut Onat

  5. Department of Periodontology, Akdeniz University, Faculty of Dentistry, Antalya, Turkey

    Kemal Üstün

Authors
  1. Ufuk Sezer
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  2. Süleyman Ziya Şenyurt
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  3. Eda Çetin Özdemir
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  8. Ahmet Mesut Onat
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Correspondence to Ufuk Sezer.

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Sezer, U., Şenyurt, S.Z., Özdemir, E.Ç. et al. Relationship between periodontal destruction and gene mutations in patients with familial Mediterranean fever. Clin Rheumatol 35, 1841–1847 (2016). https://doi.org/10.1007/s10067-015-3078-8

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  • DOI: https://doi.org/10.1007/s10067-015-3078-8

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