Clinical Rheumatology

, Volume 34, Issue 12, pp 2001–2010 | Cite as

Entheseal involvement in systemic disorders

  • Gleb SlobodinEmail author
  • Doron Rimar
  • Nina Boulman
  • Lisa Kaly
  • Michael Rozenbaum
  • Itzhak Rosner
  • Majed Odeh
Review Article


The objective of this study is to review the data on entheseal involvement in systemic disorders. A Pubmed search utilizing the indexing terms “enthesis” and “enthesitis” was conducted and the data pertinent to the aim of the review was extracted and organized in accordance with the preplanned structure of the manuscript. A number of cadaver-based studies, as well as studies using ultrasonography and magnetic resonance imaging, have detailed new distinct aspects of enthesis physiology and pathology in a variety of rheumatic and non-rheumatic systemic disorders. Major progress has been done in characterization of separate components of the enthesis organ, imaging of entheses, elaboration of the role and features of entheseal disease in spondyloarthropathies, juvenile idiopathic arthritis, osteoarthritis, familial Mediterranean fever, hyperuricemia, and other systemic conditions. The knowledge acquired and summarized herein shows that entheses can be affected in various ways in variety of medical disorders with different pathogenesis. Better understanding of the risk factors, mechanisms and natural history of enthesopathies is warranted. The current progress in the understanding of entheseal involvement in systemic disorders represents just the first step in resolving the entheses-related enigmas.


Enthesis Enthesitis Enthesopathy 





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Copyright information

© International League of Associations for Rheumatology (ILAR) 2015

Authors and Affiliations

  • Gleb Slobodin
    • 1
    • 3
    Email author
  • Doron Rimar
    • 2
    • 3
  • Nina Boulman
    • 2
    • 3
  • Lisa Kaly
    • 2
    • 3
  • Michael Rozenbaum
    • 2
    • 3
  • Itzhak Rosner
    • 2
    • 3
  • Majed Odeh
    • 1
    • 3
  1. 1.Internal Medicine ABnai Zion Medical CenterHaifaIsrael
  2. 2.RheumatologyBnai Zion Medical CenterHaifaIsrael
  3. 3.Ruth and Bruce Rappaport Faculty of MedicineTechnionHaifaIsrael

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