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Reduced ovarian reserve in patients with adult polymyositis

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Abstract

Polymyositis (PM) affects female gender during reproductive age; however, there is no study assessing ovarian reserve in these patients to evaluate ovarian reserve markers in PM. Eight female patients with PM (Bohan and Peter criteria, 1975) with aged 18–40 years, followed at our tertiary centre from March 2011 to May 2014, were invited to participate. They were age-matched with 16 healthy individuals (control group). All were evaluated at early follicular phase of menstrual cycle. Follicle stimulating hormone (FSH), estradiol, inhibin B, anti-Müllerian hormone (AMH) serum levels (ELISA) and sonographic antral follicle count (AFC) were determined. PM patients and controls had comparable mean age (31.4 ± 6.5 vs. 30.7 ± 6.2 years, P = 0.946), ethnicity and socioeconomic class (P > 0.05). PM mean age of onset was 27.3 ± 6.5 years and disease duration of 6.5 ± 4.1 years. Menstrual cycles were alike in both groups with a similar frequency of age at menarche, gynaecological age, duration and length of menstrual cycle (P > 0.05). The median serum level of AMH was significantly lower in PM compared to controls [0.7(0.3–3.4) vs. 3.1(1.4–4.0), P = 0.021]. AMH levels ≤1 ng/mL (50 vs. 6.3 %, P = 0.024) and very low AFC (37.5 vs. 6.3 %, P = 0.037) were significantly in PM patients versus controls. The other hormones (FSH, inhibin B and estradiol levels) were similar between both groups (P > 0.05). The present study was the first to identify subclinical ovarian dysfunction in PM patients during reproductive ages. Further study is necessary to assess the possible role of PM-related factors that may influence the ovarian function of these patients.

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Acknowledgments

We thank Elaine Pires Leon for technical support. This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) [2011/15609-5 to S.K.S. and 2011/12471-2 to C.A.S.]; Federico Foundation to E.B., C.A.S. and S.K.S.; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) [305068/2014-8 to E.B. and 302724/2011-7 to C.A.S.] and by Núcleo de Apoio à Pesquisa “Saúde da Criança e do Adolescente” da USP (NAP-CriAd-SP) to C.A.S.

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Authors and Affiliations

  1. Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Fernando Henrique Carlos de Souza, Clovis Artur da Silva, Vilma dos Santos Trindade Viana, Eloisa Bonfá & Samuel Katsuyuki Shinjo

  2. Division of Gynaecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Lucas Yugo Shiguehara Yamakami

  3. Pediatric Rheumatology Unit—Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Clovis Artur da Silva

  4. Disciplina de Reumatologia, Faculdade de Medicina da Universidade de São Paulo, Av. Dr. Arnaldo, 455, 3 andar, sala 3150, 01246-903, São Paulo, Brazil

    Samuel Katsuyuki Shinjo

Authors
  1. Fernando Henrique Carlos de Souza
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  2. Clovis Artur da Silva
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  3. Lucas Yugo Shiguehara Yamakami
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  4. Vilma dos Santos Trindade Viana
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  5. Eloisa Bonfá
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  6. Samuel Katsuyuki Shinjo
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Correspondence to Samuel Katsuyuki Shinjo.

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de Souza, F.H.C., da Silva, C.A., Yamakami, L.Y.S. et al. Reduced ovarian reserve in patients with adult polymyositis. Clin Rheumatol 34, 1795–1799 (2015). https://doi.org/10.1007/s10067-015-3064-1

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  • DOI: https://doi.org/10.1007/s10067-015-3064-1

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