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Molecular basis of oxidative stress in gouty arthropathy

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Abstract

Gout is a disorder of urate metabolism in which persistent high urate levels in the extracellular fluids result in the deposition of monosodium urate (MSU) crystal in joints and periarticular tissues. In recent years, this disease represents an increasingly common health problem, so the pace of investigation in the field has accelerated tremendously. New research advances in the pathogenesis of hyperuricemia and in the understanding of how MSU crystals induce an acute gouty attack have been focused in this review on the processes of inflammation and involvement of the innate immune response; in addition, we discuss new knowledge about the role of the reactive oxygen species in establishing oxidative stress in MSU crystal-induced arthritis.

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Acknowledgments

The authors wish to thank Aguilar-Gonzalez C. A. for his valuable support in the design of the figures. A.M.R.’s work was supported by grant P20GM104937 from the National Institutes of Health.

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Authors and Affiliations

  1. Molecular Synovioanalysis and Musculoskeletal Ultrasound Laboratories, Instituto Nacional de Rehabilitación, Calzada Mexico-Xochimilco 289, Col. Arenal de Guadalupe, Delegación Tlalpan, 14389, Mexico, D.F, Mexico

    Yessica Zamudio-Cuevas, Cristina Hernández-Díaz, Carlos Pineda, Lucio Ventura-Ríos & Alberto López-Reyes

  2. Molecular Microbiology Laboratory, Department of Microbiology, Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), Prolongación de Carpio y Plan de Ayala S/N, Col. Casco de Santo Tomás, Delegación Miguel Hidalgo, 11340, Mexico, D.F, Mexico

    Yessica Zamudio-Cuevas & Jorge Francisco Cerna-Cortés

  3. Rheumatology Division, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, 02903, USA

    Anthony M. Reginato

Authors
  1. Yessica Zamudio-Cuevas
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  2. Cristina Hernández-Díaz
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Correspondence to Alberto López-Reyes.

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Zamudio-Cuevas, Y., Hernández-Díaz, C., Pineda, C. et al. Molecular basis of oxidative stress in gouty arthropathy. Clin Rheumatol 34, 1667–1672 (2015). https://doi.org/10.1007/s10067-015-2933-y

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