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MicroRNAs in rheumatoid arthritis

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Abstract

The role of genetic and epigenetic factors in the development of rheumatic diseases has been an interesting field of research over the past decades all around the world. Research on the role of microRNAs (miRNAs) in rheumatoid arthritis (RA) has been active and ongoing, and investigations have attempted to use miRNAs as biomarkers in disease diagnosis, prognosis, and treatment. This review focuses on experimental researches in the field of miRNAs and RA to present the data available up to this date and includes researches searched by keywords “microRNA” and “rheumatoid arthritis” in PubMed from 2008 to January 2015. All references were also searched for related papers. miRNAs are shown to act as proinflammatory or anti-inflammatory agents in diverse cell types, and their role seems to be regulatory in most instances. Researchers have evaluated miRNAs in patients compared to controls or have investigated their role by overexpressing or silencing them. Multiple targets have been identified in vivo, in vitro, or in silico, and the researches still continue to show their efficacy in clinical settings.

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Authors and Affiliations

  1. Immunology Department, School of Medicine, Tehran University of Medical Sciences, Poursina St, Ghods St, Enghelab Ave, Tehran, 1417613151, Iran

    Eisa Salehi & Rahil Eftekhari

  2. Immunology Department, School of Public Health, Tehran University of Medical Sciences, Poursina St, Ghods St, Enghelab Ave, Tehran, 1417613151, Iran

    Mona Oraei

  3. Naamdar Medical Diagnostic Lab, Tehran University of Medical Sciences, No. 118, Fathi Shaghaghi St, Yousef Abad Ave, Tehran, Iran

    Alvand Gharib

  4. Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, No. 62, Gharib St, Keshavarz Blvd, Tehran, 14194, Iran

    Katayoon Bidad

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  1. Eisa Salehi
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Salehi, E., Eftekhari, R., Oraei, M. et al. MicroRNAs in rheumatoid arthritis. Clin Rheumatol 34, 615–628 (2015). https://doi.org/10.1007/s10067-015-2898-x

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