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Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease

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Abstract

The prevalence of coronary artery disease (CAD) is growing in the young population. We aimed to investigate the association between serum uric acid (SUA) levels and cardiovascular involvement in individuals under 45 years old diagnosed with early-onset CAD (EOCAD). Seven hundred eighty-six EOCAD patients were recruited and stratified into four groups by SUA levels. General information, serum indicators, and results of coronary angiography and echocardiography were recorded. The associations between SUA levels were explored by univariate and multivariate logistic regressions. With the increasing of SUA levels, the prevalence of hypertension and hyperlipidemia, triple branches involved, heart failure, and cardiac enlargement of left ventricle (LV), left atrium (LA), and right ventricle (RV) were significantly higher (all P < 0.05). The fourth group (SUA >8 mg/dl) had the highest proportions than other groups (all P < 0.05). After controlling potential confounders, multiple logistic regression analysis showed that odds ratios of SUA >8 mg/dl were 2.345 for triple branches involved (95 % confidence interval (CI) 1.335–4.119), 4.168 for heart failure (95 % CI 1.599–10.862), and 4.122 for LV enlargement (95 % CI 1.874–9.065) (P < 0.05). SUA >8 mg/dl was independently associated with triple branches involvement, heart failure and LV enlargement in Chinese EOCAD patients. Higher SUA level might play an important role in cardiac dysfunction and severity of EOCAD.

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Acknowledgments

The authors thank Dr. Jing-Min Zhou, Department of Cardiology, Zhongshan Hospital affiliated to Fudan University, for his kind suggestions to the study. This research received the funding of Shanghai Committee of Science and Technology Major Program (No. 11DJ1400101).

Conflict of interest

The authors declared that they had no conflicts of interest. There was no financial or personal relationship with other people or organizations that could inappropriately influence this work. We had full control of all primary data and allowed the journal to review the data if requested.

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    Authors and Affiliations

    1. Department of Rheumatology, Zhongshan Hospital affiliated to Fudan University, No. 180, Fenglin Road, Shanghai, 200032, China

      Xiao-Min Dai, Lei Wei, Li-Li Ma, Hui-Yong Chen, Zhuo-Jun Zhang, Zong-Fei Ji, Wan-Long Wu, Ling-Ying Ma, Xiu-Fang Kong & Lin-Di Jiang

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    1. Xiao-Min Dai
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    Correspondence to Lin-Di Jiang.

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    Xiao-Min Dai and Lei Wei contributed equally to this work.

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    Dai, XM., Wei, L., Ma, LL. et al. Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease. Clin Rheumatol 34, 1605–1611 (2015). https://doi.org/10.1007/s10067-015-2878-1

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    • DOI: https://doi.org/10.1007/s10067-015-2878-1

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