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Associations analysis of GSTM1, T1 and P1 Ile105Val polymorphisms with carpal tunnel syndrome

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Abstract

Oxidative stress was related with carpal tunnel syndrome (CTS). We aimed to clarify the associations between glutathione S-transferase (GST)M1, GSTT1 and GSTP1-Ile105Val polymorphisms and CTS. One hundred-forty patients with CTS and 97 healthy controls were enrolled in this study. Tinel and Phalen signs were noted as positive or negative. Functional and clinical status of patients was evaluated by the Boston Questionnaire. The intensity of hand and/or wrist pain was evaluated on 10 cm visual analog scale (VAS). We applied the polymerase chain reaction (PCR) to determine the polymorphisms of the GSTM1 and GSTT1 and the PCR-restriction fragment length polymorphism method for detecting the GSTP1-Ile105Val polymorphism. The M1 null genotype was significantly higher in patients with CTS compared to healthy controls, and the M1 null genotype seemed to increase the risk of CTS approximately two-fold (P = 0.011; odds ratio (OR) = 1.98; 95 % confidence interval (CI) 1.17–3.36). The M1 null, T1 present combined genotype was significantly higher in patients with CTS compared to healthy controls (P = 0.043); however, it seemed not to increase the risk of CTS (P = 0.14; OR = 0.62; 95 % CI 0.33–1.76). We found significantly higher levels of the VAS, Boston Symptom Severity Scale and Phalen sign in patients with the Ile/Val or the Val/Val genotypes compared to those in patients with the Ile/Ile genotype (P = 0.003, 0.004 and 0.044, respectively). We proposed that genes involved in the protection from oxidative stress may influence the susceptibility, clinical and functional status of CTS. The GSTM1 null genotype may be related with the development of CTS, whereas the Val allele of GSTP1-Ile105Val polymorphism may be associated with worse functional and clinical status in CTS.

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References

  1. Werner RA, Andary M (2002) Carpal tunnel syndrome: pathophysiology and clinical neurophysiology. Clin Neurophysiol 113:1373–1381

    Article  PubMed  Google Scholar 

  2. Kim JK, Koh YD, Kim JS, Hann HJ, Kim MJ (2010) Oxidative stress in subsynovial connective tissue of idiopathic carpal tunnel syndrome. J Orthop Res 28:1463–1468

    Article  PubMed  Google Scholar 

  3. Board PG, Menon D (2013) Glutathione transferases, regulators of cellular metabolism and physiology. Biochim Biophys Acta 1830:3267–3288

    Article  CAS  PubMed  Google Scholar 

  4. Seidegård J, Vorachek WR, Pero RW, Pearson WR (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc Natl Acad Sci U S A 85:7293–7297

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ali-Osman F, Akande O, Antoun G, Mao JX, Buolamwini J (1997) Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. J Biol Chem 272:10004–10012

    Article  CAS  PubMed  Google Scholar 

  6. Wang D, Wang B, Zhai JX, Liu DW, Sun GG (2011) Glutathione S-transferase M1 and T1 polymorphisms and cervical cancer risk: a meta-analysis. Neoplasma 58:352–359

    Article  CAS  PubMed  Google Scholar 

  7. Tang ZH, Zhang C, Cheng P, Sun HM, Jin Y, Chen YJ, Huang F (2014) Glutathione-S-transferase polymorphisms (GSTM1, GSTT1 and GSTP1) and acute leukemia risk in Asians: a meta-analysis. Asian Pac J Cancer Prev 15:2075–2081

    Article  PubMed  Google Scholar 

  8. Wang J, Jiang J, Zhao Y, Gajalakshmi V, Kuriki K, Suzuki S, Nagaya T, Nakamura S, Akasaka S, Ishikawa H, Tokudome S (2011) Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: a case–control study in an Indian population. Cancer Epidemiol 35:66–72

    Article  CAS  PubMed  Google Scholar 

  9. Bohanec Grabar P, Logar D, Tomsic M, Rozman B, Dolzan V (2009) Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis. Clin Exp Rheumatol 27:229–236

    CAS  PubMed  Google Scholar 

  10. Keenan BT, Chibnik LB, Cui J, Ding B, Padyukov L, Kallberg H, Bengtsson C, Klareskog L, Alfredsson L, Karlson EW (2010) Effect of interactions of glutathione S-transferase T1, M1, and P1 and HMOX1 gene promoter polymorphisms with heavy smoking on the risk of rheumatoid arthritis. Arthritis Rheum 62:3196–3210

    Article  PubMed  PubMed Central  Google Scholar 

  11. Economopoulos KP, Sergentanis TN (2010) GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis. Eur J Cancer 46:1617–1631

    Article  CAS  PubMed  Google Scholar 

  12. American Association of Electrodiagnostic Medicine, American Academy of Neurology, and American Academy of Physical Medicine and Rehabilitation (2002) Practice parameter for electro-diagnostic studies in carpal tunnel syndrome: summary statement. Muscle Nerve 25:918–922

    Article  Google Scholar 

  13. Sezgin M, Incel NA, Serhan S, Camdeviren H, As I, Erdoğan C (2006) Assessment of symptom severity and functional status in patients with carpal tunnel syndrome: reliability and functionality of the Turkish version of the Boston Questionnaire. Disabil Rehabil 28:1281–1285

    Article  PubMed  Google Scholar 

  14. Abbas A, Delvinquiere K, Lechevrel M, Lebailly P, Gauduchon P, Launoy G, Sichel F (2004) GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma. World J Gastroenterol 10:3389–3393

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Ye Z, Song H (2005) Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis. Eur J Cancer 41:980–989

    Article  CAS  PubMed  Google Scholar 

  16. Ateş NA, Tamer L, Ateş C, Ercan B, Elipek T, Ocal K, Camdeviren H (2005) Glutathione S-transferase M1, T1, P1 genotypes and risk for development of colorectal cancer. Biochem Genet 43:149–163

    Article  PubMed  Google Scholar 

  17. White DL, Li D, Nurgalieva Z, El-Serag HB (2008) Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis. Am J Epidemiol 167:377–389

    Article  PubMed  Google Scholar 

  18. Hosgood HD 3rd, Berndt SI, Lan Q (2007) GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: a meta-analysis. Mutat Res 636:134–143

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Tang ST, Wang CJ, Tang HQ, Zhang Q, Wang Y (2013) Evaluation of glutathione S-transferase genetic variants affecting type 2 diabetes susceptibility: a meta-analysis. Gene 530:301–308

    Article  CAS  PubMed  Google Scholar 

  20. Eslami S, Sahebkar A (2014) Glutathione-S-transferase M1 and T1 null genotypes are associated with hypertension risk: a systematic review and meta-analysis of 12 studies. Curr Hypertens Rep 16:432

    Article  PubMed  Google Scholar 

  21. Bid HK, Konwar R, Saxena M, Chaudhari P, Agrawal CG, Banerjee M (2010) Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population. J Postgrad Med 56:176–181

    Article  CAS  PubMed  Google Scholar 

  22. Gönül N, Kadioglu E, Kocabaş NA, Ozkaya M, Karakaya AE, Karahalil B (2012) The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: a case–control study in a Turkish population. Gene 505:121–127

    Article  PubMed  Google Scholar 

  23. Yun BR, El-Sohemy A, Cornelis MC, Bae SC (2005) Glutathione S-transferase M1, T1, and P1 genotypes and rheumatoid arthritis. J Rheumatol 32:992–997

    CAS  PubMed  Google Scholar 

  24. Morinobu S, Morinobu A, Kanagawa S, Hayashi N, Nishimura K, Kumagai S (2006) Glutathione S-transferase gene polymorphisms in Japanese patients with rheumatoid arthritis. Clin Exp Rheumatol 24:268–273

    CAS  PubMed  Google Scholar 

  25. Lu Y, Shi Y, Yin J, Huang Z (2013) Are glutathione S-transferase polymorphisms (GSTM1, GSTT1) associated with primary open angle glaucoma? A meta-analysis. Gene 527:311–315

    Article  CAS  PubMed  Google Scholar 

  26. Cheng SL, Yu CJ, Chen CJ, Yang PC (2004) Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD. Eur Respir J 23:818–824

    Article  CAS  PubMed  Google Scholar 

  27. Mo Z, Gao Y, Cao Y, Gao F, Jian L (2009) An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. Prostate 69:662–688

    Article  CAS  PubMed  Google Scholar 

  28. Kiss I, Németh A, Bogner B, Pajkos G, Orsós Z, Sándor J, Csejtey A, Faluhelyi Z, Rodler I, Ember I (2004) Polymorphisms of glutathione-S-transferase and arylamine N-acetyltransferase enzymes and susceptibility to colorectal cancer. Anticancer Res 24:3965–3970

    CAS  PubMed  Google Scholar 

  29. Economopoulos KP, Choussein S, Vlahos NF, Sergentanis TN (2010) GSTM1 polymorphism, GSTT1 polymorphism, and cervical cancer risk: a meta-analysis. Int J Gynecol Cancer 20:1576–1580

    Article  PubMed  Google Scholar 

  30. de Jong MM, Nolte IM, te Meerman GJ, van der Graaf WT, de Vries EG, Sijmons RH, Hofstra RM, Kleibeuker JH (2002) Low-penetrance genes and their involvement in colorectal cancer susceptibility. Cancer Epidemiol Biomarkers Prev 11:1332–1352

    PubMed  Google Scholar 

  31. Sergentanis TN, Economopoulos KP (2010) GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 121:195–202

    Article  CAS  PubMed  Google Scholar 

  32. Economopoulos KP, Sergentanis TN, Vlahos NF (2010) Glutathione S-transferase M1, T1, and P1 polymorphisms and ovarian cancer risk: a meta-analysis. Int J Gynecol Cancer 20:732–737

    Article  PubMed  Google Scholar 

  33. Lecomte T, Landi B, Beaune P, Laurent-Puig P, Loriot MA (2006) Glutathione S-transferase P1 polymorphism (Ile105Val) predicts cumulative neuropathy in patients receiving oxaliplatin-based chemotherapy. Clin Cancer Res 12:3050–3056

    Article  CAS  PubMed  Google Scholar 

  34. Biswas A, Sadhukhan T, Bose K, Ghosh P, Giri AK, Das SK, Ray K, Ray J (2012) Role of glutathione S-transferase T1, M1 and P1 polymorphisms in Indian Parkinson’s disease patients. Parkinsonism Relat Disord 18:664–665

    Article  PubMed  Google Scholar 

  35. Yu Z, Li Z, Cai B, Wang Z, Gan W, Chen H, Li H, Zhang P, Li H (2013) Association between the GSTP1 Ile105Val polymorphism and prostate cancer risk: a systematic review and meta-analysis. Tumour Biol 34:1855–1863

    Article  CAS  PubMed  Google Scholar 

  36. Zhao Y, Wang Q, Deng X, Shi P, Wang Z (2013) Quantitative assessment of the association between GSTP1 gene Ile105Val polymorphism and susceptibility to hepatocellular carcinoma. Tumour Biol 34:2121–2126

    Article  CAS  PubMed  Google Scholar 

  37. Inada M, Sato M, Morita S, Kitagawa K, Kawada K, Mitsuma A, Sawaki M, Fujita K, Ando Y (2010) Associations between oxaliplatin-induced peripheral neuropathy and polymorphisms of the ERCC1 and GSTP1 genes. Int J Clin Pharmacol Ther 48:729–734

    Article  CAS  PubMed  Google Scholar 

  38. Lang J, Song X, Cheng J, Zhao S, Fan J (2012) Association of GSTP1 Ile105Val polymorphism and risk of head and neck cancers: a meta-analysis of 28 case–control studies. PLoS One 7:e48132

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Ankara Occupational Disease Hospital, Ankara, Turkey

    Pınar Eroğlu

  2. Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Süleyman Demirel University, Çünür, Isparta, Turkey

    Esra Erkol İnal

  3. Department of Medical Genetics, Faculty of Medicine, Uludağ University, Bursa, Turkey

    Şebnem Özemri Sağ, Özlem Görükmez, Ali Topak & Tahsin Yakut

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  1. Pınar Eroğlu
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Correspondence to Esra Erkol İnal.

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Eroğlu, P., Erkol İnal, E., Sağ, Ş.Ö. et al. Associations analysis of GSTM1, T1 and P1 Ile105Val polymorphisms with carpal tunnel syndrome. Clin Rheumatol 35, 1245–1251 (2016). https://doi.org/10.1007/s10067-014-2855-0

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  • DOI: https://doi.org/10.1007/s10067-014-2855-0

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