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Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study

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Abstract

To evaluate the efficacy and safety of hyaluronic acid (HA) and glucosamine sulfate (GS) in alleviating symptoms and improving function of Kashin-Beck disease (KBD). A cluster-randomized, placebo-controlled trial was conducted in 150 patients with KBD. Participants were randomly allocated to receive intra-articular injection hyaluronic acid (IAHA) for 4 weeks, oral GS for 12 weeks, or oral placebo for 12 weeks. The primary outcome measures were 20 % and 50 % reductions in pain from baseline measured by the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index. Secondary outcome measures included WOMAC index parameters of pain, stiffness, and physical function. The third outcome measure was mean change in Lequence score. HA and GS were effective in reducing WOMAC pain by 20 % (differences of 43.5 % and 25.4 %) and 50 % (differences of 43.4 % and 26.9 %). Both HA and GS significantly reduced WOMAC pain, WOMAC stiffness, and WOMAC normalized score compared with placebo group (all P < 0.05). IAHA was significantly more effective than oral GS in improving WOMAC normalized score (P = 0.034), pain (P = 0.002), stiffness (P = 0.018), and function (P = 0.044). The results indicate that HA and GS were more effective than placebo in treating KBD and HA was more effective than GS.

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Conflict of interest

We declare that we have no conflict of interest.

Role of the funding source

This work was supported by the National Natural Scientific Foundation of China (30972556) and “13115” Major program on Technology Science Innovation Project of Shaanxi Province (2009ZDKG-79).

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Authors and Affiliations

  1. Institute of Endemic Diseases of School of Public Health, Health Science Center, Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China

    Chuan-tao Xia, Fang-fang Yu, Feng-ling Ren, Hua Fang & Xiong Guo

  2. Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi’an, 710061, People’s Republic of China

    Chuan-tao Xia, Fang-fang Yu, Feng-ling Ren, Hua Fang & Xiong Guo

  3. Key Laboratory of Trace elements and Endemic Diseases, Ministry of Health, Xi’an, 710061, People’s Republic of China

    Chuan-tao Xia, Fang-fang Yu, Feng-ling Ren, Hua Fang & Xiong Guo

  4. School of Public Health, Health Science Centre, Xi’an Jiaotong University, No 76 Yanta West Road, Xi’an, Shaanxi, 710061, People’s Republic of China

    Xiong Guo

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  1. Chuan-tao Xia
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  2. Fang-fang Yu
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Correspondence to Xiong Guo.

Additional information

Chuan-tao Xia and Fang-fang Yu contributed equally to this work and should be considered co-first authors.

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Xia, Ct., Yu, Ff., Ren, Fl. et al. Hyaluronic acid and glucosamine sulfate for adult Kashin-Beck disease: a cluster-randomized, placebo-controlled study. Clin Rheumatol 35, 1263–1270 (2016). https://doi.org/10.1007/s10067-014-2809-6

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  • DOI: https://doi.org/10.1007/s10067-014-2809-6

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