Skip to main content

Advertisement

SpringerLink
Log in

Takayasu’s arteritis in Arabs

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

The objective of this study was to describe epidemiological and clinical features of Takayasu’s arteritis (TA) among Arab populations and to compare it to other populations. We conducted a systematic review of reports about TA from Arab countries published in English and French until 2013. All published papers were reviewed including original research and case reports. There were 197 patients (176 females) reported in 28 publications that comprised 8 original research publications (with a total of 163 patients) and 20 case reports (reporting 34 patients). These patients were from countries with a total population of approximately 80 million (Tunisia, Morocco, Jordan, Lebanon, Kuwait, Saudi Arabia, and Bahrain). The female to male ratio was 7:1. Mean age at disease onset was 28 years, and the mean delay in diagnosis was 3.5 years. Clinical manifestations are constitutional symptoms in 44 %, limb claudication in 64 %, Raynaud’s in 6 %, erythema nodosum in 3.6 %, visual disturbances in 30 %, carotidynia in 7 %, neurologic manifestations in 56 %, and hypertension in 34.5 % of patients. Involvement of the aortic arch and its branches were observed in about 80 % of patients. The overall mortality was very low over a period of 5.4 years of follow-up, and the course of the disease was quite stable in about 50 % of patients. The demographical and clinical findings of TA in Arabs are similar to what has been reported from different parts of the world. A relatively long delay in diagnosis may be in part due to low awareness of a relatively rare disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Toshihiko N (1996) Current status of large and small vessel vasculitis in Japan. Int J Cardiol 54:S91–S98

    Article  PubMed  Google Scholar 

  2. Nasu T (1975) Takayasu’s truncoarteritis in Japan. A statistical observation of 76 autopsy cases. Pathol Microbiol (Basel) 43:140–146

    CAS  Google Scholar 

  3. Cotch MF (2000) The socioeconomic impact of vasculitis. Curr Opin Rheumatol 12:20–23

    Article  CAS  PubMed  Google Scholar 

  4. Waern AU, Andersson P, Hemingsson A (1983) Takayasu’s arteritis: a hospital-region based study on occurrence, treatment and prognosis. Angiology 34:311–320

    Article  CAS  PubMed  Google Scholar 

  5. Watts R, Al-Taiar A, Mooney J, Scott D, Macgregor A (2009) The epidemiology of Takayasu arteritis in the UK. Rheumatology (Oxford) 48:1008–1011

    Article  Google Scholar 

  6. Hall S, Barr W, Lie JT, Stanson AW, Kazmier FJ, Hunder GG (1985) Takayasu arteritis. A study of 32 North American patients. Medicine (Baltimore) 64:89–99

    Article  CAS  Google Scholar 

  7. Sharma BK, Sagar S, Singh AP et al (1992) (1998) Takayasu arteritis in India. Heart Vessels Suppl 7:37–43

    Article  CAS  PubMed  Google Scholar 

  8. Cañas CA, Jimenez PCA, Ramirez LA et al (1998) Takayasu arteritis in Colombia. Int J Cardiol 66(suppl 1):S73–S79

    Article  PubMed  Google Scholar 

  9. Koide K (1992) Takayasu arteritis in Japan. Heart Vessel 7(Suppl):48–54

    Article  CAS  Google Scholar 

  10. Moriwaki R, Noda M, Yajima M, Sharma BK, Numano F (1997) Clinical manifestations of Takayasu arteritis in India and Japan—new classification of angiographic findings. Angiology 48:369–379

    CAS  PubMed  Google Scholar 

  11. Kerr GS, Hallahan CW, Giordano J et al (1994) Takayasu arteritis. Ann Intern Med 120:919–929

    Article  CAS  PubMed  Google Scholar 

  12. Al Jishi A, Krishnan PR, Almawi WY (2005) Takayasu arteritis with high titre of antiphospholipid antibodies and MTHFR polymorphism. J Thromb Thrombolysis 20:47–50

    Article  Google Scholar 

  13. el-Reshaid K, Varro J, al-Duwairi Q, Anim JT (1995) Takayasu’s arteritis in Kuwait. J Trop Med Hyg 98:299–305

    CAS  PubMed  Google Scholar 

  14. Uthman I, Masri AF, Kassak K, Arnaout S (1998) Angiographic findings of Takayasu’s arteritis in Lebanon. Br J Rheumatol 37:1030

    Article  CAS  PubMed  Google Scholar 

  15. Atallah N, Smayra T, Slaba S, Menassa L (1998) Percutaneous renal angioplasty. Experience of the radiodiagnostic service of the Hotel-Dieu of France. J Med Liban 46:244–250

    CAS  PubMed  Google Scholar 

  16. Uthman IW, Bizri AR, Hajj Ali RA et al (1999) Takayasu’s arteritis presenting as fever of unknown origin: report of two cases and literature review. Semin Arthritis Rheum 28:280–285

    Article  CAS  PubMed  Google Scholar 

  17. Ghosn S, Malek J, Shbaklo Z, Matta M, Uthman I (2008) Takayasu disease presenting as malignant pyoderma gangrenosum in a child with relapsing polychondritis. J Am Acad Dermatol 59(5 Suppl):S84–S87

    Article  PubMed  Google Scholar 

  18. Uthman IW, Chaaban H (2006) The use of sildenafil in pediatric Takayasu arteritis. Clin Rheumatol 25:550

    Article  PubMed  Google Scholar 

  19. El Mesnaoui A, Sedki N, Bouarhroum A, Sedki A, El Mahi O, Alaoui M, El Idrissi R, Sefiani Y, Lekehal B, Benjelloun A, Ammar F, Bensaïd Y (2007) Cerebral revascularisation in Takayasu’s arteritis. Ann Cardiol Angeiol (Paris) 56:130–136

    Article  Google Scholar 

  20. Abid-Allah M, Fadouach S, Chraibi N, Mehadji BA (1999) Cardiac manifestations of Takayasu’s arteritis: apropos of 5 cases. Rev Med Interne 20:476–482

    Article  CAS  PubMed  Google Scholar 

  21. Kamaoui I, Souirti M, Zteou B, Omari N, Houssaini NS, Messouak O, Belahsen F, Tizniti S (2007) Ischemic stroke caused by Takayasu’s arteritis. J Mal Vasc 32:4346

    Article  Google Scholar 

  22. el Asri A, Tazi-Mezalek Z, Aouni M, Adnaoui M, Mohattane A, Bensaid Y, Maaouni A (2002) Takayasu’s disease in Morocco. Report of 47 cases. Rev Med Interne 23:9–20

    Article  PubMed  Google Scholar 

  23. Belyamani L, Azendour H, Elmoqadem A, Kouach J, Zidouh S, Drissi Kamili N (2009) Takayasu and pregnancy. Ann Cardiol Angeiol (Paris) 58:187–188

    Article  CAS  Google Scholar 

  24. El Kouache M, Marmade L, Tribak M, Moughil S, Bensouda A, Filal J, Benomar A, Ouazzani MT, Abir S, Benomar MH (2008) Takayas’s arteritis revealed by aortic regurgitation with ascending aortic aneurysm (about 2 cases). Ann Cardiol Angeiol Paris 57:246–250

    Article  PubMed  Google Scholar 

  25. Khalaf HH, Arafah MR, Refaat AA, Ibrahim MF (2006) Coronary arteries bypass grafting for Takayasu arteritis with severe coronary, carotid, subclavian, and renal artery involvement and subsequent pregnancy. Interact Cardiovasc Thorac Surg 5:153–155

    Article  PubMed  Google Scholar 

  26. Al-Hulaimi N, Al-Saileek A, Ahmed T, Al-Zaibag M, Pai RG, El-Widaa H (2001) Mixed aneurysmal and obstructive coronary artery disease causing acute myocardial infarction in a young woman with Takayasu’s arteritis. Can J Cardiol 17:602–605

    CAS  PubMed  Google Scholar 

  27. Ashmeik K, Al-Anazi M, Idris M (1998) Pan-valvular annular calcification in Takayasu’s arteritis: report of 3 cases. J Am Soc Echocardiogr 11:1166–1170

    Article  CAS  PubMed  Google Scholar 

  28. Ashraf S, Alkarawi MA, Alokaily F, Alkhushail A, Alrobayan A (2009) Takayasu’s arteritis associated with Crohn’s disease: a case report and literature review. BMJ Case Rep bcr07.2008.0490

  29. Basri NA, Shaheen FA (2003) Renal transplantation for Takayasu’s arteritis: a case report. Transplant Proc 35:2617–2618

    Article  CAS  PubMed  Google Scholar 

  30. Al-Ghamdi AA (2003) Successful pregnancy in a patient with Takayasu’s arteritis. Saudi Med J 24:1250–1253

    PubMed  Google Scholar 

  31. Ben Dhaou B, Aydi Z, Boussema, Ben Dahmen F, Baili L, Ketari S, Kochbati S, Cherif O, Rokbani (2012) Takayasu’s arteritis in Tunisia: a monocentric study of 11 patients. Tunis Med 90:867–872

    PubMed  Google Scholar 

  32. Kechaou M, Frigui M, Ben Hmida M, Bahloul Z (2009) Takayasu arteritis in southern Tunisia: a study of 29 patients. Presse Med 38:1410–1414

    Article  PubMed  Google Scholar 

  33. Ghannouchi Jaafoura N, Khalifa M, Rezgui A, Alaoua A, Ben Jazia E, Braham A et al (2010) Takayasu’s disease in the center of Tunisia: 27 cases. J Mal Vasc 35:4–11

    Article  CAS  PubMed  Google Scholar 

  34. Sraieb T, RomdhaneB N, Longo S, Salious C, Manaa JL (2003) Treatment of Takayasu arteritis in the chronic stages: an analysis of 14 operated patients. Int J Angiol 12:196–200

    Article  Google Scholar 

  35. Hamzaoui A, Salem R, Klii R, Harzallah O, Berriche O, Golli M, Mahjoub S (2011) Co-existing sarcoidosis and Takayasu arteritis: report of a case. Int Arch Med 4:9

    Article  PubMed Central  PubMed  Google Scholar 

  36. Quali S, Kacem S, Ben Fradj F, Gribaa R, Naffeti E, Remedi F, Laaoueni C, Boughzela E (2011) Takayasu arteritis with coronary aneurysms causing acute myocardial infarction in a young man. Tex Heart Inst J 38:183–186

    Google Scholar 

  37. Ben Fredj Ismail F, Hadj Khelifa S, Toumi Ghannouchi S, Mrad B, Mhiri HH, Mazhoud J, Ben Ali A, Cheouech A, Laouani Kechrid C (2011) Isolated abdominal pain revealing a paraprosthetic fistula in a patient with Takayasu arteritis. Rev Med Interne 32(1):e9–e11

    Article  CAS  PubMed  Google Scholar 

  38. Frikha F, Maazoun F, Snoussi M, Abid L, Abid H, Bouassida W, Kaddour N, Bahloul Z (2012) Takayasu’s arteritis and rheumatoid arthritis: a rare association—about an observation. Pan Afr Med J 12:61

    PubMed Central  PubMed  Google Scholar 

  39. Mustafa KN, Hadidy A, Sweiss NJ (2010) Clinical and radiological features of Takayasu’s arteritis patients in Jordan. Rheumatol Int 30:1449–1453

    Article  PubMed  Google Scholar 

  40. Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, Lie JT, Lightfoot RW Jr et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33:1129–1134

    Article  CAS  PubMed  Google Scholar 

  41. Bicakcigil M, Aksu K, Kamali S, Ozbalkan Z, Ates A, Karadag O, Ozer HT et al (2009) Takayasu’s arteritis in Turkey—clinical and angiographic features of 248 patients. Clin Exp Rheumatol 27:S59–S64

    CAS  PubMed  Google Scholar 

  42. Karageorgaki ZT, Bertsias GK, Mavragani CP, Kritikos HD, Spyropoulou-Vlachou M, Drosos AA, Boumpas DT (2009) Moutsopoulos HM (2009) Takayasu arteritis: epidemiological, clinical, and immunogenetic features in Greece. Clin Exp Rheumatol 27(1 Suppl 52):S33–S39

    CAS  PubMed  Google Scholar 

  43. Sheikhzadeh A, Tettenborn I, Noohi F, Eftekharzadeh M, Schnabel A (2002) Occlusive thromboaortopathy (Takayasu disease): clinical and angiographic features and a brief review of literature. Angiology 53:29–40

    Article  CAS  PubMed  Google Scholar 

  44. Park MC, Lee SW, Park YB, Chung NS, Lee SK (2005) Clinical characteristics and outcomes of Takayasu’s arteritis: analysis of 108 patients using standardized criteria for diagnosis, activity assessment, and angiographic classification. Scand J Rheumatol 34(4):284–292

    Article  PubMed  Google Scholar 

  45. Ureten K, Oztürk MA, Onat AM, Oztürk MH, Ozbalkan Z, Güvener M, Kiraz S, Ertenli I, Calgüneri M (2004) Takayasu’s arteritis: results of a university hospital of 45 patients in Turkey. Int J Cardiol 96:259–264

    Article  PubMed  Google Scholar 

  46. Bilge NS, Kaşifoğlu T, Cansu DU, Korkmaz C (2012) Retrospective evaluation of 22 patients with Takayasu’s arteritis. Rheumatol Int 32:1155–1159

    Article  PubMed  Google Scholar 

  47. Türkoğlu C, Memiş A, Payzin S, Akin M, Kültüsay H, Akilli A, Can L, Altintiğ A (1996) Takayasu arteritis in Turkey. Int J Cardiol 54(Suppl):S135–S136

    Article  PubMed  Google Scholar 

  48. Cong XL, Dai SM, Feng X, Wang ZW, Lu QS, Yuan LX, Zhao XX, Zhao DB, Jing ZP (2010) Takayasu’s arteritis: clinical features and outcomes of 125 patients in China. Clin Rheumatol 29:973–981

    Article  PubMed  Google Scholar 

  49. Vanoli M, Daina E, Salvarani C, Sabbadini MG, Rossi C, Bacchiani G et al (2005) Takayasu’s arteritis: a study of 104 Italian patients. Arthritis Rheum 53:100–107

    Article  CAS  PubMed  Google Scholar 

  50. Sato EI, Hatta FS, Levy-Neto M, Fernandes S (1998) Demographic, clinical, and angiographic data of patients with Takayasu arteritis in Brazil. Int J Cardiol 66(Suppl 1):S67–S70

    Article  PubMed  Google Scholar 

  51. Moriwaki R, Numano F (1992) Takayasu arteritis: follow-up studies for 20 years. Heart Vessel 7:138–145

    Article  CAS  Google Scholar 

  52. Ishikawa K (1981) Survival and morbidity after diagnosis of occlusive thromboaortopathy (Takayasu’s disease). Am J Cardiol 47:1026–1032

    Article  CAS  PubMed  Google Scholar 

  53. Suwanwela N, Piyachon C (1996) Takayasu arteritis in Thailand: clinical and imaging features. Int J Cardiol 54(Suppl):S117–S134

    Article  PubMed  Google Scholar 

Download references

Disclosure

None.

Author information

Authors and Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Jordan University Hospital, The University of Jordan, Queen Rania St, PO Box 13046, Amman, 11942, Jordan

    Khader N. Mustafa

Authors
  1. Khader N. Mustafa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Khader N. Mustafa.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mustafa, K.N. Takayasu’s arteritis in Arabs. Clin Rheumatol 33, 1777–1783 (2014). https://doi.org/10.1007/s10067-014-2633-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-014-2633-z

Keywords

Search

Navigation