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Inflammatory myopathy with anti-SRP antibodies: case series of a South Australian cohort

Clinical Rheumatology volume 34, pages 603–608 (2015)Cite this article

Abstract

Myopathy associated with anti-signal recognition particle (SRP) antibodies is a rare form of myopathy, which is thought to be distinct from classic polymyositis. We sought to determine the demographic, clinical and histopathological features of patients with anti-SRP antibodies. Hence we undertook an audit of patients with histologically-confirmed myositis who had anti-SRP antibodies. Of 144 patients with inflammatory myositis tested for myositis-specific and myositis-associated antibodies between 2007 and 2011 inclusive, five with anti-SRP antibodies were identified. All five were male, four had severe proximal weakness, one was asymptomatic and three had dysphagia. None had cardiovascular involvement. All patients showed isolated anti-SRP positivity and absence of antinuclear antibodies. Muscle histopathology showed variable myofibre necrosis, and most had an inflammatory infiltrate. Majority showed a favorable response to combination immunosuppressive therapy. Myopathy associated with anti-SRP antibodies is clinically heterogeneous in presentation. Muscle histopathology shows a mixture of necrotic and inflammatory features.

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Acknowledgments

Jim Manavis is acknowledged for assistance with histopathology.

Disclosures

None.

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Affiliations

  1. Rheumatology Department, Royal Adelaide Hospital, North Tce, Adelaide, SA, 5000, Australia

    Sajini K Basnayake & Vidya Limaye

  2. Department of Pathology, University of Adelaide, Adelaide, Australia

    Peter Blumbergs

  3. Immunology Department, Flinders Medical Centre, Bedford Park, Australia

    Ju Ann Tan & Peter J Roberts-Thompson

  4. Immunology Department, SA Pathology, Wayville, Australia

    Peter J Roberts-Thompson

  5. Department of Medicine, Adelaide University, Adelaide, Australia

    Peter J Roberts-Thompson & Vidya Limaye

Authors
  1. Sajini K Basnayake
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  2. Peter Blumbergs
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  3. Ju Ann Tan
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  4. Peter J Roberts-Thompson
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  5. Vidya Limaye
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Correspondence to Vidya Limaye.

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Basnayake, S.K., Blumbergs, P., Tan, J.A. et al. Inflammatory myopathy with anti-SRP antibodies: case series of a South Australian cohort. Clin Rheumatol 34, 603–608 (2015). https://doi.org/10.1007/s10067-014-2512-7

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  • DOI: https://doi.org/10.1007/s10067-014-2512-7

Keywords

  • Histopathology
  • Muscle biopsy
  • Myositis
  • Necrotizing myopathy
  • Polymyositis
  • SRP antibodies